Results 81 to 90 of about 5,465,744 (330)

Why the Cameron-Clegg coalition will be a shock to both Tory and Liberal Democrat voters [PDF]

open access: yes, 2010
There has been intensive speculation about how Conservative and Liberal Democrat voters will react to the coalition government cemented in their name.
Norris, Pippa
core  

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham   +21 more
wiley   +1 more source

The Far Right in Western Europe: “From the Margins to the Mainstream” And Back?

open access: yesCuadernos Europeos de Deusto, 2018
This paper analyses the rise of the Far Right in Western Europe and the widespread political, social and scholarly concern due to the extremist parties’ recent electoral performances. It holds that, already since the late 1980s, we are witnessing a new (
Beatriz Acha Ugarte
doaj   +1 more source

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

open access: yesMolecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts   +8 more
wiley   +1 more source

When history becomes a metaphor for the present and the future: recent far-right discourse about immigration in the UK

open access: yesLexis: Journal in English Lexicology, 2014
Based on conceptual and discourse-oriented metaphor theory, the article argues that British far-right discourse increasingly conceptualizes immigration with the help of martial rather than “fluid” or “container” metaphors.
Anne Friederike Delouis
doaj   +1 more source

Gendering Web2.0 Sociotechnical Affordances of Far-Right Metapolitics

open access: yesSocial Media + Society, 2022
This study examines the ways in which Web2.0 sociotechnical affordances of far-right metapolitics are gendered. Specifically, I focus on a key Swedish far-right entity that is not only an extensive publisher of far-right intellectual output, but also ...
Ov Cristian Norocel
doaj   +1 more source

Emerging role of ARHGAP29 in melanoma cell phenotype switching

open access: yesMolecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster   +3 more
wiley   +1 more source

A Mixed-Method Analysis of Fatal Attacks on Police by Far-Right Extremists [PDF]

open access: yes, 2015
Several recent high-profile homicides of police officers have brought increased attention to issues of far-right extremist violence in the United States.
Chermak, Steven M.   +4 more
core   +1 more source

Gut microbiota diversity is prognostic in metastatic hormone receptor‐positive breast cancer patients receiving chemotherapy and immunotherapy

open access: yesMolecular Oncology, EarlyView.
In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern   +7 more
wiley   +1 more source

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