Results 31 to 40 of about 277,747 (258)

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

open access: yesFEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Results of Work of the Specialized Anti-Epidemic Teams of the Irkutsk Research Anti-Plague Institute in the Amur Region, Khabarovsk Territory and the Jewish Autonomous Region in 2013

open access: yesПроблемы особо опасных инфекций, 2014
Displayed are the major results of work of the specialized anti-epidemic teams from Irkutsk Research Anti-Plague Institute, aimed at the provision for sanitary-epidemiological welfare of the population in the Amur Region, Khabarovsk Territory and the ...
S. V. Balakhonov   +8 more
doaj   +1 more source

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

open access: yesFEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux   +7 more
wiley   +1 more source

Renal rupture and retroperitoneal hematoma in obstetric practice: a case report

open access: yesГинекология
Spontaneous rupture of the kidney during pregnancy is an uncommon but potentially life-threatening condition that poses significant risks to both the mother and the child.
Victoria A. Tkachenko   +3 more
doaj   +1 more source

The Role of Brucella abortus I-206 Thermoextracts in L- and S-form in Shaping the Immune Response in White Mice

open access: yesЭпидемиология и вакцинопрофилактика, 2019
Background. Brucellosis is an acute infectious-allergic zoonotic disease in which sick farm animals are the main source of infection for humans. Immunization of animals and people on the territory of Russia is carried out by live vaccines, which, having ...
V. I. Dubrovina   +8 more
doaj   +1 more source

Smaller is better: nanobodies meet NMR

open access: yesFEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

KDAC6 alters cell morphology and motility through positive and negative modulation of F‐actin distribution

open access: yesFEBS Open Bio, EarlyView.
KDAC6 has been associated with cell motility and actin structures, but specific domain contributions are not established. The two catalytic domains have differential effects on motility and F‐actin regulation, affecting cortical F‐actin density, motility, stress fibers, and cell spreading.
Taylor V. Joseph   +7 more
wiley   +1 more source

In silico and in vitro exploration of a tyrosinase for biocatalytic production of catechols

open access: yesFEBS Open Bio, EarlyView.
Tyrosinase from Ralstonia pseudosolanacearum is a promising biocatalyst for producing valuable catechols from monophenol substrates. This tyrosinase is uniquely suited to this due to its high monophenolase : diphenolase ratio. We combined in silico docking and in vivo kinetic characterisation of this tyrosinase with 11 industrially relevant monophenols,
James Britton   +6 more
wiley   +1 more source

THE NEW SPRING SOFT WHEAT VARIETY ‘ANFEYA’

open access: yesЗерновое хозяйство России, 2019
The improvement of high-quality grain production remains the most important task for the entire agricultural sector of Russia, including the Far Eastern region.
T. A. Aseeva   +3 more
doaj   +1 more source

NEW DATA ON THE AGE OF COAL-BEARING STRATA IN THE SOUTHWESTERN PRIMORYE AND THEIR SIGNIFICANCE FOR CENOZOIC STRATIGRAPHY OF THE FAR EAST

open access: yesИзвестия Томского политехнического университета: Инжиниринг георесурсов, 2022
The relevance of the research is conditioned by the need to eliminate the existing division of opinions about the age of the commercially coal-bearing Paleogene deposits in the southwestern Primorye and neighboring territories.
Aleksandr A. Chashchin   +5 more
doaj   +1 more source

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