Results 51 to 60 of about 5,577,824 (355)

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source

Peculiarities of the Effect of the Lipopolysaccharide of Tularemia Microbe of Different Subspecies upon Metabolic Activity of Phagocytes in Vitro

Проблемы особо опасных инфекций, 2011
Experimental preparations of the lipopolysaccharide (LPS) of Francisella tularensis of four subspecies (tularensis, holarctica, mediasiatica, novicida) were obtained using Tween extraction method.
V. I. Dubrovina, Zh. A. Konovalova, V. B. Nikolaev, V. V. Voitkova, S. A. Tatarnikov, A. V. Mazepa, E. Yu. Markov, Yu. O. Popova, O. V. Yur`eva   +8 more
doaj   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

The Role of Brucella abortus I-206 Thermoextracts in L- and S-form in Shaping the Immune Response in White Mice

Эпидемиология и вакцинопрофилактика, 2019
Background. Brucellosis is an acute infectious-allergic zoonotic disease in which sick farm animals are the main source of infection for humans. Immunization of animals and people on the territory of Russia is carried out by live vaccines, which, having ...
V. I. Dubrovina, T. P. Starovoitova, S. A. Vityazeva, N. L. Barannikova, T. A. Ivanova, G. B. Mukhturgin, A. V. Gromova, G. Yu. Sorkina, S. V. Balakhonov   +8 more
doaj   +1 more source

Prevalence of Helicobacter pylori in patients with gastro-oesophageal reflux disease : systematic review. [PDF]

, 2003
Objectives: To ascertain the prevalence of Helicobacter pylori in patients with gastro-oesophageal reflux disease and its association with the disease.
Childs, S., Hungin, A. P. S., Raghunath, A., Wooff, D.   +3 more
core   +2 more sources

Remarkable Records of Micarea from the Russian Far East and Significant Extension of Micarea Laeta and M. Microareolata Range

, 2019
The aim of the study was to consolidate data on lichens of the genus Micarea Fr. from the Russian Far East. A total of 19 Micarea species were found to be known from this area. Micarea laeta and M. microareolata were new to Asia and Russia. Additionally,
L. Konoreva, S. Chesnokov, E. Kuznetsova, I. Stepanchikova   +3 more
semanticscholar   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Results of Work of the Specialized Anti-Epidemic Teams of the Irkutsk Research Anti-Plague Institute in the Amur Region, Khabarovsk Territory and the Jewish Autonomous Region in 2013

Проблемы особо опасных инфекций, 2014
Displayed are the major results of work of the specialized anti-epidemic teams from Irkutsk Research Anti-Plague Institute, aimed at the provision for sanitary-epidemiological welfare of the population in the Amur Region, Khabarovsk Territory and the ...
S. V. Balakhonov, S. A. Kosilko, A. K. Noskov, L. M. Mikhailov, M. V. Chesnokova, E. S. Kulikalova, V. A. Vishnyakov, N. V. Breneva, N. G. Gefan   +8 more
doaj   +1 more source

Geochronological and geochemical features of magmatic gold- and silverbearing complexes in the Chukotka sector of the Russian Arctic coast

Литосфера, 2020
Research subject. This study was devoted to magmatic complexes in Northwestern Chukotka associated with the largest gold and silver deposits across Kupol’skii (Kupol field) and Ilirnei (Dvoinoe and September fields) ore junctions.
V. G. Sakhno, L. S. Tsurikova, S. O. Maksimov   +2 more
doaj   +1 more source

Metabolism features and milk microbiota of cows with mastitis in the Amur Oblast

Ветеринария сегодня, 2023
The effective management practices of dairy farming are inextricably linked with the production of high quality milk, while the mastitis is one of the causes of reductions in milk yields and quality.
M. E. Ostyakova, I. S. Shulga, V. K. Irkhina, K. S. Kositsyna, N. S. Golaydo   +4 more
doaj   +1 more source