Results 41 to 50 of about 1,582,854 (217)

Study of Supernova Neutrinos at ESSnuSB

Universe
In this paper, we have studied the sensitivity of the ESSnuSB far detector to supernova neutrinos. ESSnuSB is a proposed long-baseline neutrino experiment in Sweden, which will use a 538 kt water Cherenkov detector to probe the leptonic phase δCP by ...
J. Aguilar, M. Anastasopoulos, D. Barčot, E. Baussan, A. K. Bhattacharyya, A. Bignami, M. Blennow, M. Bogomilov, B. Bolling, E. Bouquerel, F. Bramati, A. Branca, G. Brunetti, I. Bustinduy, C. J. Carlile, J. Cederkall, T. W. Choi, S. Choubey, P. Christiansen, E. Cristaldo Morales, P. Cupiał, D. D’Ago, H. Danared, J. P. A. M. de André, M. Dracos, I. Efthymiopoulos, T. Ekelöf, M. Eshraqi, G. Fanourakis, A. Farricker, E. Fasoula, T. Fukuda, S. Gago, N. Gazis, Th. Geralis, M. Ghosh, A. Giarnetti, G. Gokbulut, C. Hagner, L. Halić, J. Hiegel, M. Hooft, K. E. Iversen, N. Jachowicz, M. Jakkapu, M. Jensen, I. Karakoulias, E. Kasimi, A. Kayis Topaksu, B. Kliček, K. Kordas, B. Kovač, A. Leisos, A. Longhin, M. López, C. Maiano, S. Marangoni, J. G. Marcos, C. Marrelli, D. Meloni, M. Mezzetto, N. Milas, R. Mohanta, J. L. Muñoz, K. Niewczas, M. Oglakci, T. Ohlsson, M. Olvegård, P. Panda, M. Pari, D. Patrzalek, G. Petkov, Ch. Petridou, P. Poussot, A. Psallidas, F. Pupilli, D. Saiang, D. Sampsonidis, A. Scanu, C. Schwab, F. Sordo, G. Stavropoulos, M. Stipčević, R. Tarkeshian, F. Terranova, T. Tolba, M. Topp-Mugglestone, E. Trachanas, R. Tsenov, A. Tsirigotis, S. E. Tzamarias, M. Vanderpoorten, G. Vankova-Kirilova, N. Vassilopoulos, S. Vihonen, J. Wurtz, V. Zeter, O. Zormpa   +97 more
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Comparison of a coupled near- and far-wake model with a free-wake vortex code [PDF]

Wind Energy Science, 2017
This paper presents the integration of a near-wake model for trailing vorticity, which is based on a prescribed-wake lifting-line model proposed by Beddoes(1987), with a blade element momentum (BEM)-based far-wake model and a 2-D shed vorticity model.
G. Pirrung, V. Riziotis, H. Madsen, M. Hansen, T. Kim   +4 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

A Study on the Quality Assessment of the Chinese-English Subtitle Translation among Four Machine Translation Tools - A Case Study of Wreaths at the Foot of the Mountain

transLogos: Translation Studies Journal
As artificial intelligence (AI) continues to evolve, machine translation (MT), particularly neural MT, is experiencing rapid development and innovation, significantly influencing leading MT applications in China.
Xu Zhou, Jinghua Zhou
doaj   +1 more source

An implicit-explicit time splitting strategy for the far SOL plasma fluid model with DG-FEM discretization [PDF]

EPJ Web of Conferences
We consider a far scrape-off layer (SOL) plasma fluid model of ions that is governed by a Braginskiitype model: a one-dimensional, nonlinear system of advection-diffusion equations coupled with a diffusion equation for neutral particles.
Burkovska Olena, Barnett Rhea L., Vogl Christopher J., Lore Jeremy D., Hauck Cory   +4 more
doaj   +1 more source