Results 51 to 60 of about 1,680 (194)

Estrategias de negocios de las farmacias del municipio Maracaibo

Telos: Revista de Estudios Interdisciplinarios en Ciencias Sociales, 2008
El propósito fundamental de este estudio fue analizar las estrategias de negocios aplicadas por las farmacias ubicadas en el municipio Maracaibo, bajo los preceptos teóricos de Thompson y Strickland (2003) y Villalba (2000).
Giancarlo Salazar, Wileidys Artigas
doaj  

The Comparative Effectiveness of Vector Control Approaches for Dengue: A Systematic Review and Multilevel Network Meta‐Analysis

Tropical Medicine &International Health, EarlyView.
ABSTRACT Background Dengue vector control plays an important role in reducing the burden of dengue infection. Conventional meta‐analysis can only include interventions that can be directly compared. Hence, this study aimed to compare the effectiveness of all interventions for dengue vector control directly and indirectly through a multilevel Bayesian ...
Gary K. K. Low, Yuling Ke, Emmanuel Samson, Prutha Rane, Olaf Horstick, Carlos Alberto Montenegro‐Quiñonez   +5 more
wiley   +1 more source

Target‐Engagement Prediction From Molecular Structure, In Vitro and Animal Data: A Tutorial for Early Assessment of Clinical Drug Exposure and Therapeutic/Adverse Potential Using the ANDROMEDA and PLATO Software on the InSilicoTrials Platform

CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 11, November 2026.
ABSTRACT The target‐engagement predictor, implemented within the InSilicoTrials cloud‐based, AI‐powered platform for model‐informed drug discovery and development, enables early exploration of time‐dependent pharmacological responses. Predictions can be generated using inputs ranging from molecular structure to in vitro, animal, and clinical data ...
Niccolò Totis, Fianne Sips, Simona Catozzi, Marc‐Antonio Bisotti, Pauline Bambury, Sofia Stathopoulos, Vincenzo Carbone, Luca Emili, Mario Torchia, Valentina Belgiovine, Fulvio Ciriaco, Orazio Nicolotti, Urban Fagerholm, Candice N. Baker, J. Matthew Mahoney, Daniel Röshammar, on behalf of the CARDIOVERSE Project   +16 more
wiley   +1 more source

Bisphenols and Phthalates in Bottled Mineral Water: First Evidence of Co‐Occurrence, Estrogenic Activity, and Health Risk in Brazil

Environmental Toxicology, Volume 41, Issue 11, Page 1179-1187, November 2026.
ABSTRACT Bisphenol A (BPA), its structural analogs, and phthalates are synthetic chemicals widely used, with documented endocrine‐disrupting activity. This study aimed to develop and validate a selective multiresidue analytical method for the simultaneous determination of BPA, 10 bisphenol analogs, and six phthalates in PET‐bottled mineral water.
Giulia Boito Reyes, Lucas Correia Gonçalves, Fernanda Cristina Iba Molinari, José Eduardo Gonçalves   +3 more
wiley   +1 more source

High‐Resolution LC–MS/MS Characterization of Budmunchiamine‐Type Alkaloids in Albizia niopoides

Rapid Communications in Mass Spectrometry, Volume 40, Issue 19, 15 October 2026.
ABSTRACT Rationale Budmunchiamines are macrocyclic spermine alkaloids that constitute a distinctive class of polyamine natural products predominantly found in species of the genus Albizia. Comprehensive characterization of these compounds remains challenging because of their structural diversity and the limited availability of reference standards. This
Maria L. A. Majevski, Lienne D'Auria Lima, Adriana C. C. Reis, Leonan I. C. R. Santos, Brenno F. S. Vargas, Markus Kohlhoff, Geraldo Célio Brandão   +6 more
wiley   +1 more source

In Silico to In Cerebro—Development of the Orexin Receptor Antagonist “Photorexant” for Photomodulation In Vitro and in Mouse Brains

Angewandte Chemie International Edition, Volume 65, Issue 42, 12 October 2026.
Following a structure‐based design approach, photoswitchable derivatives of the FDA‐approved drug suvorexant were designed, docked, synthesized, and characterized pharmacologically at the orexin 1 and 2 receptors (OX1R and OX2R). Optimized “photorexant” showed up to an 11‐fold difference in IC50 between photoisomers, enabled dynamic and reversible ...
Marcus Angermann, Marie H. Deventer, Vicente Ledesma‐Martin, Nuno Martinho, Alix Flake, Silvia Mori, Angel Nuñez, Jaime Pignatelli, Rita C. Guedes, Christophe P. Stove, Michael Decker   +10 more
wiley   +1 more source

Thiolated Alginate for Mucoadhesive and Redox‐Responsive Drug Delivery: Chemistry, Structure‐Function Relationships and Translational Development

Applied Research, Volume 5, Issue 5, October 2026.
Thiol and disulfide modifications can help alginate carriers adhere to mucus and release drugs in response to reducing environments. This review links modification chemistry to delivery performance and highlights reproducible manufacturing, stability, and safety validation as priorities for clinical translation.
Parteek Prasher, Mousmee Sharma, Rabab Fatima, Shraddha Chugh, Harish Mudila, Flavia Zacconi, Javad Sharifi‐Rad, Daniela Calina, William N. Setzer   +8 more
wiley   +1 more source

Análisis de la demanda de antibióticos en farmacia comunitaria con receta privada, prescripción irregular y sin receta (automedicación): perfil de las farmacias y los farmacéuticos comunitarios participantes

Farmacéuticos Comunitarios, 2018
Introducción: La resistencia a los antibióticos constituye uno de los mayores desafíos que afronta la medicina en la actualidad. Es una amenaza creciente para la salud pública que afecta a todos los países del mundo debido a que los nuevos mecanismos de ...
Molinero A, Carbajal de-Lara JA, Cantalapiedra Fernández F, Eguilleor Villena A, Gutiérrez Ríos P   +4 more
doaj   +1 more source

Chemometric‐Assisted Extraction Optimization and HPLC‐MS Profiling of Mentha × villosa Targeting Photoprotective Activity

Chemistry &Biodiversity, Volume 23, Issue 10, October 2026.
Design‐of‐experiments optimization, followed by LC–MS profiling and chemometric analysis, led to a phenolic‐rich Mentha × villosa extract with strong antioxidant activity and photoprotective effects enhancing the performance of ethylhexyl methoxycinnamate in sunscreen‐based formulations. ABSTRACT Mentha × villosa is a food and medicinal plant with long
Juliana de Medeiros Gomes, Thalisson Amorim de Souza, Márcio Vinícius Cahino Terto, Maria Beatriz Félix Mendes Nunes, Hariel Maffei Umesaki Tessaro, Joanda Paolla Raimundo e Silva, Samuel Paulo Cibulski, Luiz Alberto Lira Soares, Vera Isaac, Marcelo Sobral da Silva, Josean Fechine Tavares   +10 more
wiley   +1 more source

Seasonal and Regional Variation of the Chemical Composition and Antimicrobial Activity of Essential Oils From Piper marginatum Jacq.

Chemistry &Biodiversity, Volume 23, Issue 10, October 2026.
Evaluating Piper marginatum essential oils across three Brazilian biomes reveals significant chemical and antimicrobial variations driven by seasonal and regional factors. Sixty compounds are identified, including a novel (Z)‐phenylpropanoid reported for the first time. Multivariate analysis correlates environmental stressors with specialized metabolic
Rebeca Gabriel de Camargo, Marta Cristina Teixeira Duarte, Diones Krinski, Ana Paula Palaro Klein Hendges, Aurea Portes Ferriani, Francisco de Assis Marques, Thalita Gilda Santos, Beatriz Helena Lameiro de Noronha Sales Maia   +7 more
wiley   +1 more source