Results 1 to 10 of about 20,583 (144)

Analysis of 2′-hydroxyflavanone (2HF) in mouse whole blood by HPLC–MS/MS for the determination of pharmacokinetic parameters [PDF]

Frontiers in Chemistry, 2023
Given the lack of investments, structure, and difficulty of metabolite isolation, promising natural product studies do not progress to preclinical studies, such as pharmacokinetics.
Luiza F. O. Gervazoni, Gabriella Gonçalves-Ozorio, Taiana Ferreira-Paes, Aline C. A. Silva, Gabriel P. E. Silveira, Heliana M. Pereira, Douglas P. Pinto, Edézio F. Cunha-Junior, Elmo E. Almeida-Amaral   +8 more
doaj   +2 more sources

PI-07: THE INTERNATIONAL HEMOGLOBINOPATHY RESEARCH NETWORK (INHERENT): AN INTERNATIONAL INITIATVE TO STUDY THE ROLE OF GENETIC MODIFIERS IN HEMOGLOBINOPATHIES [PDF]

Hemasphere, 2022
HemaSphere, Volume 6, Issue S4, Page 12-13, August 2022.
P. K, C. S, N. A, F. B, V. G, K. K, A. M, J. M, M. M, K. M, S. N, O. N, S. T, L. T, A. W, B. Z, B. I, M. K.   +17 more
europepmc   +2 more sources

Pharmacokinetics and therapeutic target attainment of vancomycin in pediatric post-liver transplant patients [PDF]

Brazilian Journal of Infectious Diseases, 2023
Introduction: Vancomycin is widely prescribed to treat or prevent Gram-positive infections in pediatric liver transplant recipients. The objective of this prospective cohort study is to describe vancomycin pharmacokinetics and to evaluate the therapeutic
Ronaldo Morales Junior, Vanessa D'Amaro Juodinis, Daniela Carla de Souza, Silvia Regina Cavani Jorge Santos   +3 more
doaj   +2 more sources

Herramientas informáticas gratuitas y online para dosificación de precisión de vancomicina, y otros fármacos [PDF]

Revista de la Facultad de Ciencias Médicas de Córdoba
Introducción: Las herramientas informáticas que asisten en la optimización farmacoterapéutica de fármacos de estrecho margen terapéutico están ampliamente disponibles.
Marianela Isabel Quereilhac, Guillermo Federico Taboada, Paulo Caceres Guido   +2 more
doaj   +2 more sources

Selección de variantes farmacogenómicas y metodología para su uso en farmacia comunitaria [PDF]

Farmacéuticos Comunitarios
Los organismos reguladores, como la Food and Drug Administration (FDA) y la European Medicines Agency (EMA), reconocen la farmacogenética como una herramienta clave en sus guías farmacológicas para el asesoramiento farmacéutico.
Almudena Montero-Gómez, Antonio Sánchez Pozo   +1 more
doaj   +2 more sources

Noncompartmental pharmacokinetics of three intravenous mycophenolate mofetil concentrations in healthy Standardbred mares

Veterinary Dermatology, Volume 34, Issue 3, Page 222-234, June 2023., 2023
Background – Mycophenolate mofetil (MMF) is the prodrug of mycophenolic acid (MPA) which acts as an immunosuppressive agent. During the biotransformation of MMF to MPA, additional metabolites including MPA phenol glucuronide (MPAG), MPA acyl glucuronide (AcMPAG) and MPA phenol glucoside (MPG) are formed.
Dylan L. Burroughs, Gwendolen Lorch, Yizhen Guo, Kasey Hill, Eric L. Schroeder, Lynette K. Cole, Mitch A. Phelps   +6 more
wiley   +1 more source

FARMACOCINÉTICA E MECANISMOS DE TERATOGENICIDADE DOS MEDICAMENTOS NA GESTAÇÃO: UMA REVISÃO DA LITERATURA [PDF]

Infarma: Pharmaceutical Sciences, 2017
As alterações fisiológicas que ocorrem no organismo feminino durante o período gestacional é assunto bastante explorado pelos pesquisadores e encontra-se bem elucidado pela literatura; porém a temática relativa à farmacocinética e os mecanismos de ...
Andréia Moreira ANDRADE, Alanderson Alves RAMALHO, Simone Perufo OPITZ, Fernanda Andrade MARTINS, Rosalina Jorge KOIFMAN   +4 more
doaj   +1 more source

Bioanalytical method by HPLC-FLD for curcumin analysis in supplemented athletes

Saudi Pharmaceutical Journal, 2020
In sports, curcumin, a substance derived from the rhizome of Curcuma longa (turmeric) plant with antioxidant effect 8 times greater than vitamin E, has attracted the attention of scientists because of its potent antioxidant action, since in athletes ...
Alisson Henrique Antunes, Flávia Rasmussen Faria, João Felipe Mota, Mariângela Fontes Santiago, Ana Carolina Kogawa, Kênnia Rocha Rezende   +5 more
doaj   +1 more source

Potential Pharmacokinetic Drug‐Drug Interactions between Cannabinoids and Drugs Used for Chronic Pain

BioMed Research International, Volume 2020, Issue 1, 2020., 2020
Choosing an appropriate treatment for chronic pain remains problematic, and despite the available medication for its treatment, still, many patients complain about pain and appeal to the use of cannabis derivatives for pain control. However, few data have been provided to clinicians about the pharmacokinetic drug‐drug interactions of cannabinoids with ...
Marta Vázquez, Natalia Guevara, Cecilia Maldonado, Paulo Cáceres Guido, Paula Schaiquevich, Eiichi Kumamoto   +5 more
wiley   +1 more source

Optimization of a drug simultaneous dissolution and permeability screening method

Saúde & Tecnologia, 2014
The goal of this research project was the optimization of a method for simultaneously screen the dissolution rate and the permeability of drug formulations across Polyvinylidene Fluoride membranes, using a bilateral flow cell.
Pedro Ferreira, Hugo Serra, João Mário Pedro, Anabela Graça, Ana Luísa Simplício   +4 more
doaj   +1 more source