Analysis of 2′-hydroxyflavanone (2HF) in mouse whole blood by HPLC–MS/MS for the determination of pharmacokinetic parameters [PDF]
Frontiers in Chemistry, 2023 Given the lack of investments, structure, and difficulty of metabolite isolation, promising natural product studies do not progress to preclinical studies, such as pharmacokinetics.
Luiza F. O. Gervazoni +8 more
doaj +2 more sources
PI-07: THE INTERNATIONAL HEMOGLOBINOPATHY RESEARCH NETWORK (INHERENT): AN INTERNATIONAL INITIATVE TO STUDY THE ROLE OF GENETIC MODIFIERS IN HEMOGLOBINOPATHIES [PDF]
Hemasphere, 2022 HemaSphere, Volume 6, Issue S4, Page 12-13, August 2022.
P. K +17 more
europepmc +2 more sources
Herramientas informáticas gratuitas y online para dosificación de precisión de vancomicina, y otros fármacos [PDF]
Revista de la Facultad de Ciencias Médicas de CórdobaIntroducción: Las herramientas informáticas que asisten en la optimización farmacoterapéutica de fármacos de estrecho margen terapéutico están ampliamente disponibles.
Marianela Isabel Quereilhac +2 more
doaj +2 more sources
Selección de variantes farmacogenómicas y metodología para su uso en farmacia comunitaria [PDF]
Farmacéuticos ComunitariosLos organismos reguladores, como la Food and Drug Administration (FDA) y la European Medicines Agency (EMA), reconocen la farmacogenética como una herramienta clave en sus guías farmacológicas para el asesoramiento farmacéutico.
Almudena Montero-Gómez +1 more
doaj +2 more sources
Veterinary Dermatology, Volume 34, Issue 3, Page 222-234, June 2023., 2023 Background – Mycophenolate mofetil (MMF) is the prodrug of mycophenolic acid (MPA) which acts as an immunosuppressive agent. During the biotransformation of MMF to MPA, additional metabolites including MPA phenol glucuronide (MPAG), MPA acyl glucuronide (AcMPAG) and MPA phenol glucoside (MPG) are formed.
Dylan L. Burroughs +6 more
wiley +1 more source
FARMACOCINÉTICA E MECANISMOS DE TERATOGENICIDADE DOS MEDICAMENTOS NA GESTAÇÃO: UMA REVISÃO DA LITERATURA [PDF]
Infarma: Pharmaceutical Sciences, 2017 As alterações fisiológicas que ocorrem no organismo feminino durante o período gestacional é assunto bastante explorado pelos pesquisadores e encontra-se bem elucidado pela literatura; porém a temática relativa à farmacocinética e os mecanismos de ...
Andréia Moreira ANDRADE +4 more
doaj +1 more source
Bioanalytical method by HPLC-FLD for curcumin analysis in supplemented athletes
Saudi Pharmaceutical Journal, 2020 In sports, curcumin, a substance derived from the rhizome of Curcuma longa (turmeric) plant with antioxidant effect 8 times greater than vitamin E, has attracted the attention of scientists because of its potent antioxidant action, since in athletes ...
Alisson Henrique Antunes +5 more
doaj +1 more source
BioMed Research International, Volume 2020, Issue 1, 2020., 2020 Choosing an appropriate treatment for chronic pain remains problematic, and despite the available medication for its treatment, still, many patients complain about pain and appeal to the use of cannabis derivatives for pain control. However, few data have been provided to clinicians about the pharmacokinetic drug‐drug interactions of cannabinoids with ...
Marta Vázquez +5 more
wiley +1 more source
Optimization of a drug simultaneous dissolution and permeability screening method
Saúde & Tecnologia, 2014 The goal of this research project was the optimization of a method for simultaneously screen the dissolution rate and the permeability of drug formulations across Polyvinylidene Fluoride membranes, using a bilateral flow cell.
Pedro Ferreira +4 more
doaj +1 more source
Optimização de um método de avaliação simultânea da dissolução e permeabilidade de fármacos
Saúde & Tecnologia, 2008 Englobado na temática do desenvolvimento de métodos in vitro para avaliação da biodisponibilidade de fármacos, este trabalho de investigação teve como objectivo a optimização de um método para avaliar em simultâneo a dissolução e permeabilidade de ...
Pedro Ferreira +4 more
doaj +1 more source