Results 231 to 240 of about 25,460,781 (313)

Discriminator‐Guided Inverse Folding for Multi‐Property Protein Design

Advanced Science, EarlyView.
Discriminator‐Guided Inverse Folding (DGIF) integrates multiple property predictors trained from single‐property datasets to guide protein sequence generation from a backbone structure. DGIF enables simultaneous improvement of thermostability and solubility without requiring multi‐property annotated datasets and generates designs that move toward the ...
Yuchuan Zheng, Chuyi Liu, Zhaoming Liu, Mao Su, Chenyu Tang, Xiang Zheng, Hao Zhang, Jingyuan Li   +7 more
wiley   +1 more source

Mineral Concentration in Spring Wheat Grain Under Organic, Integrated, and Conventional Farming Systems and Their Alterations During Processing. [PDF]

Plants (Basel)
Wysocka K, Cacak-Pietrzak G, Sosulski T.
europepmc   +1 more source

CCL3 and IL‐7 Synergistically Enhance CAR‐T Efficacy in Solid Tumors

Advanced Science, EarlyView.
Synergistic delivery of CCL3 and IL‐7 by CAR‐T cells overcomes the immunosuppressive tumor microenvironment by enhancing cell infiltration, survival, and local immune reprogramming. This also establishes positive feedback that amplifies anti‐tumor activity and memory responses in both CAR‐T and endogenous T cells, presenting a robust therapeutic ...
Huanpeng Chen, Xiaoyun Luo, Huixin Gao, Yujing Ke, Yu Zhan, Xiaoting Xu, Xiaoxiao Xiong, Fengjiao Wei, Si Yang, Zhonghua Liu, Bolan Yu, Zhaofeng Huang, Yingjie Bian   +12 more
wiley   +1 more source

Farmer adaptation strategies through local farming systems in Enrekang, Indonesia. [PDF]

Sci Rep
Yusriadi Y, Cahaya A, Hamzah F.
europepmc   +1 more source

Robust Amorphous MOF‐Based Aerogels Digital Biosensor for Sensitive Detection of Organophosphate Pesticides

Advanced Science, EarlyView.
We report a robust aerogel digital biosensor by integrating an enzyme‐mediated amorphous MOF within an aerogel matrix for on‐site pesticide detection. The enzyme‐mediated assembly strategy enables in situ tailoring of MOF into a porous amorphous structure, achieving both high stability and activity.
Changshun Su, Xiangyu Zhai, Houru Li, Yijie Wang, Hongxia Li, Yueyao Jiang, Geyu Lu, Xu Yan   +7 more
wiley   +1 more source

Wheat field earthworms under divergent farming systems across a European climate gradient. [PDF]

Ecol Appl
Nuutinen V, Briones MJI, Schrader S, Dekemati I, Grujić N, Hyvönen J, Ivask M, Lassen SB, Lloret E, Ollio I, Pérez-Rodríguez P, Simon B, Sutri M, de Sutter N, Brandt KK, Peltoniemi K, Shanskiy M, Waeyenberge L, Martínez-Martínez S, Fernández-Calviño D.   +19 more
europepmc   +1 more source

A Brain‐Penetrant Nanobody Reveals GSK3β‐Driven Proline‐Directed Phosphorylation as a Master Regulator of Ischemic Neurodegeneration

Advanced Science, EarlyView.
A brain‐targeted nanoparticle enables delivery of a therapeutic nanobody (Nb.29E9) that inhibits pathogenic GSK3β signaling. This intervention restores AMPK/mTORC1/TGFβ homeostasis, attenuates neuroinflammation and oxidative stress, and promotes long‐term functional recovery after ischemic stroke.
Lan Li, Muyang Li, Lei Sun, Ying Yang, Yuanshun Wu, Ziyi Yin, Anni Wang, Peiyang Zhou, Shaoxiang Luo, Jian Chen, Jun Qin, Zhibing Ai, Zilong Yuan, Zhiqiang Dong, Min Zhang   +14 more
wiley   +1 more source

The Political, Economic and Socio-Cultural Discourse Surrounding the Backyard Chicken-Rearing Farming Systems in the Western and North-Western Provinces of Sri Lanka. [PDF]

Vet Med Sci
De Zoysa MIL, Silva-Fletcher A, Herath HMAS, Yalegama MMSL, Kalupahana RS, Satharasinghe HAS, Kalupahana AW, Karunarathna EMDDK, De Alwis KGDTL.   +8 more
europepmc   +1 more source

A Conserved DT2‐bZIP66‐NF‐YC4 Regulatory Module Confers Drought Tolerance in Rice and Arabidopsis

Advanced Science, EarlyView.
This study identifies a conserved tripartiteDT2–bZIP66–NF‐YC4 transcriptional module that enhances rice drought tolerance by activating stress‐responsive genes. This regulatory complex is functionally conserved across cereals and Arabidopsis, providing promising targets for engineering drought‐resilient crops. ABSTRACT Drought stress severely restricts
Jun Shen, Yuchen Li, Liang Zhang, Xiaosong Ma, Chenyin Peng, Chunting Yuan, Yu Wu, Kaiyu Zhao, Sheng Zhao, Jiazhuo Guo, Run Li, Ziqian Yan, Shule Ren, Yige Han, Xin Lin, Xinyue Li, Ming Li, Pingfang Yang, Shiyong Song   +18 more
wiley   +1 more source

Aflatoxin M1 Content and Mastitis-Causing Bacteria in Milk from Skopelos Dairy Goats Reared in Extensive and Intensive Farming Systems. [PDF]

Animals (Basel)
Stavropoulos I, Basdagianni Z, Manessis G, Tsiftsi A, Bossis I.   +4 more
europepmc   +1 more source