Results 231 to 240 of about 114,798 (264)
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Intestinal microbiota-farnesoid X receptor axis in metabolic diseases
Clinica Chimica Acta, 2020Studies have demonstrated that intestinal microbiota is associated with various metabolic diseases including obesity, nonalcoholic fatty liver, and insulin resistance. Farnesoid X receptor (FXR), also known as the bile acid receptor, belongs to the nuclear receptor superfamily, which is involved in the regulation of bile acid, glucose, and lipid ...
Bu Zou +5 more
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Farnesoid X receptor modulators (2011 – 2014): a patent review
Expert Opinion on Therapeutic Patents, 2015Farnesoid-X-receptor (FXR) is the receptor for primary bile acids expressed in enterohepatic tissues where it regulates bile acid uptake, metabolism and disposal. For its role as a bile acid sensor, FXR has been thought to be an important target in the treatment of cholestatic disorders, a family of diseases in which endogenous bile acids accumulate in
SEPE, VALENTINA +3 more
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The role of farnesoid X receptor in metabolic diseases, and gastrointestinal and liver cancer
Nature reviews: Gastroenterology & hepatology, 2021Lulu Sun, Jie Cai, F. Gonzalez
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Farnesoid X Receptor: From Medicinal Chemistry To Clinical Applications
Future Medicinal Chemistry, 2012The farnesoid X receptor (FXR) is a bile sensor that acts in coordination with other nuclear receptors to regulate essential steps in bile acid uptake, metabolism and excretion. In addition, FXR is an ancillary receptor involved in lipid and glucose homeostasis. Steroidal and non-steroidal FXR ligands are currently available.
S. Fiorucci +3 more
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Farnesoid X Receptor: From Structure to Potential Clinical Applications
Journal of Medicinal Chemistry, 2005AbstractFor Abstract see ChemInform Abstract in Full Text.
PELLICCIARI R +2 more
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Oleanolic acid is a selective farnesoid X receptor modulator
Phytotherapy Research, 2009AbstractOleanolic acid (OA) is an ingredient found in some Traditional Chinese Medicine remedies for treating liver ailments. Bile acid biosynthesis and catabolism are in part controlled in the liver by transcription factor farnesoid X receptor (FXR). It was hypothesized that OA may act through FXR to mediate some of its beneficial health effects.
Wenming, Liu, Chiwai, Wong
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Farnesoid X receptor agonists for primary biliary cirrhosis
Current Opinion in Gastroenterology, 2011This review will provide an overview of the role of nuclear receptors in bile acid homeostasis with a focus on the farnesoid X receptor (FXR) and its potential therapeutic use in cholestatic liver diseases.Nuclear receptors have emerged as important mediators of a variety of metabolic and transport functions involving the liver.
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Targeting farnesoid X receptor for liver and metabolic disorders
Trends in Molecular Medicine, 2007The farnesoid X receptor (FXR) is a metabolic nuclear receptor expressed in the liver, intestine, kidney and adipose tissue. By regulating the expression and function of genes involved in bile acid (BA) synthesis, uptake and excretion, FXR has emerged as a key gene involved in the maintenance of cholesterol and BA homeostasis. FXR ligands are currently
FIORUCCI, Stefano +4 more
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Farnesoid X receptor agonists suppress hepatic apolipoprotein CIII expression
Gastroenterology, 2003Increased serum triglyceride levels constitute a risk factor for coronary heart disease. Apolipoprotein CIII (Apo CIII) is a determinant of serum triglyceride metabolism. In this study, we investigated whether activators of the nuclear farnesoid X receptor (FXR) modulate Apo CIII gene expression.The influence of bile acids and synthetic FXR activators ...
Thierry, Claudel +8 more
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