Results 61 to 70 of about 15,163 (264)

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

YlmG1 is localized exclusively to the chloroplast envelope membrane and is involved in preprotein translocation in Arabidopsis thaliana

FEBS Open Bio, EarlyView.
Cytosolically synthesized chloroplast preproteins are translocated across the outer and inner envelope membranes through translocons called TOC and TIC, respectively. In green algae and plants, the TIC core is composed of essential membrane proteins, Tic12, Tic20, and Tic214.
Mengyi Li, Xueyang Zhao, Masato Nakai
wiley   +1 more source

FARS-ADL across Ataxias: Construct Validity, Sensitivity to Change, and Minimal Important Change [PDF]

BackgroundPatient-focused outcomes present a central need for trial-readiness across all ataxias. The Activities of Daily Living part of the Friedreich Ataxia Rating Scale (FARS-ADL) captures functional impairment and longitudinal change but is only ...
Klopstock, Thomas, Falkenburger, Bjoern H., Traschuetz, Andreas, Oztop-Cakmak, Ozgur, Synofzik, Matthis, Fleszar, Zofia, Hengel, Holger, Pedroso, Jose Luiz, Schoels, Ludger, Erdlenbruch, Friedrich, Klockgether, Thomas, Santorelli, Filippo M.   +11 more
core   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Population pyramid of Fars province, 1999 and 2009.

, 2016
This figure provides population distributions in Fars province including both sexes from 1999 to 2009.
Zahra Khosravizadegan (2807026), Seyed Hamidreza Tabatabaee (2807017), Seyed Masoom Masoompour (2807020), Mohsen Moghadami (285731), Kamran B. Lankarani (2807023), Behnam Honarvar (285729)   +5 more
core   +1 more source

Why human connection is the true metric of research success

FEBS Open Bio, EarlyView.
Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan, Mattias Wei Ren Kon, Xavier Coumoul, Fun Man Fung   +3 more
wiley   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

In a land far, far away…

, 2011
QITL-4 - Proceedings of Quantitative Investigations in Theoretical Linguistics 4, 29.03.2011 - 31.03.2011, Berlin, Humboldt-Universität, pp 89 ...
Theijssen, Daphne, Bresnan, Joan, Ford, Marilyn   +2 more
openaire   +1 more source

FARS EDEBİYATI'NDA BEHLÛL HİKÂYELERİ

, 2019
ÖZ Behlûl, Kûfeli bir mecnunun ismidir. Harun Reşid’in akrabası olarak kabul edilir. İnsanlar onu “akıllı deli” diye adlandırırlar. Hakkında hikmet dolu hikâyeler anlatılır. Behlûl’ün Fars Edebiyatı’nda önemli bir yeri vardır.
A.Hilâl KALKANDELEN
core   +1 more source

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

FEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento, Danniel Pereira‐Figueiredo, Gabriella Grossi de Lima Dias, Gabriel Ferreira dos Santos, Mariana Rodrigues Pereira, Rafael Brito, Karin C Calaza   +6 more
wiley   +1 more source