Results 221 to 230 of about 115,762 (301)

Immune Exhaustion in Chronic Infection and Cancer: Signaling Pathways and Therapeutic Interventions

MedComm, Volume 7, Issue 3, March 2026.
Immune exhaustion is a well‐established hallmark of both cancer and chronic infection. This review proposes a novel “infection–exhaustion–tumor axis” framework, wherein chronic pathogens (e.g., oncogenic viruses) evade immune surveillance by hijacking inflammatory signaling to drive immune cell exhaustion, thereby creating immunosuppressive niches ...
Yali Song, Yazhi Mo, Si Chen, Yuemei Chen, Chunying Zhang, Shanying Deng, Juan Liao, Yi He, Wei Wang, Weidong Zheng, Tingting Zeng   +10 more
wiley   +1 more source

Fas ligand neutralization attenuates hypertension, endothelin-1, and placental inflammation in an animal model of HELLP syndrome.

Am J Physiol Regul Integr Comp Physiol, 2020
Gibbens J, Spencer SK, Solis L, Bowles T, Kyle PB, Szczepanski JL, Dumas JP, Robinson R, Wallace K.   +8 more
europepmc   +1 more source

The Contribution of Cholesterol and Squalene Synthase in Cancer: Molecular Mechanisms, Lipid Rafts and Therapeutic Approaches

Medicinal Research Reviews, Volume 46, Issue 2, Page 352-381, March 2026.
ABSTRACT A plethora of cellular signaling pathways are dysregulated in cancer cells, promoting carcinogenesis and migration. Cholesterol has recently been linked to cancer by several subcellular mechanisms, especially by its involvement in the formation of lipid rafts, which promote oncogenic signaling and cancer cell invasion. Squalene synthase (SQS),
Danai Mavridi, Theodora Katavati, Angeliki P. Kourounakis   +2 more
wiley   +1 more source

INVOLVEMENT OF FAS AND FAS‐LIGAND IN CYSTIC FIBROSIS

Journal of Pediatric Gastroenterology and Nutrition, 1998
L. Maiuri, G. De Marco, V. Raia, F. Raimondi, G. De Ritis, S. Cucchiara, S. Auricchio, S. Quaratino, M. Londei   +8 more
openaire   +2 more sources

Prokaryotic PfaB is a terminal acyltransferase that determines the final PUFA product

Protein Science, Volume 35, Issue 3, March 2026.
Abstract Omega‐3 polyunsaturated fatty acids (PUFAs) are essential for human health due to their numerous beneficial biological properties. These compounds are synthesized in marine bacteria and eukaryotic microalgae by PUFA megasynthases (Pfas), which are evolutionarily related to fatty acid synthases (FAS) and polyketide synthases (PKS). In FAS, PKS,
Nahuel Lofeudo, Aurora Martín, Mateo Jácome, Xia Wan, María Lucas, Gabriel Moncalián   +5 more
wiley   +1 more source

T‐Cell Immunity and Lung Cancer

Respirology, Volume 31, Issue 3, Page 236-249, March 2026.
ABSTRACT Lung cancer remains a leading cause of cancer mortality worldwide. Although immune checkpoint inhibitors (ICIs) have reshaped therapeutic strategies in lung cancer, their benefits remain limited. ICIs exert their therapeutic efficacy by activating T‐cell effector functions, underscoring the central role of T cells in antitumor immunity.
Kotaro Yamada, Yosuke Togashi
wiley   +1 more source

Soluble Fas Ligand Is Essential for Blister Formation in Pemphigus. [PDF]

Front Immunol, 2018
Lotti R, Shu E, Petrachi T, Marconi A, Palazzo E, Quadri M, Lin A, O'Reilly LA, Pincelli C.   +8 more
europepmc   +1 more source

Interactions Between Dissolved Organic Carbon and Aluminium Activity in Tropical and Temperate No‐Till Agroecosystems

Journal of Sustainable Agriculture and Environment, Volume 5, Issue 1, March 2026.
Conceptual model of depth‐stratified soil acidification under long‐term no‐till in temperate (Washington, USA) and tropical (Brazilian Oxisol) systems. Nitrogen inputs promote surface acidification (↓pH) and increased Al3+ activity, while lime or silicate amendments modify base cation dynamics. Increased DOC–Al complexation reduces free Al3+ and alters
Joao A. Antonangelo, Richard T. Koenig
wiley   +1 more source

Trends in Dietary Exosome‐Like Nanoparticles: Preparation, Nutritional Functions, Bioactive Delivery Efficacy, Human Health Effects, and Future Product Development

Small Structures, Volume 7, Issue 3, March 2026.
This graphical abstract summarizes the current advances in dietary exosome‐like nanoparticles (ELNs), highlighting their biogenesis pathways (MVB‐dependent, vacuole‐mediated, and EXPO routes), molecular composition (nucleic acids, lipids, proteins, and bioactive compounds), and major preparation strategies including differential ultracentrifugation ...
Nidesha Randeni, Jinhai Luo, Min‐Hsiung Pan, Baojun Xu   +3 more
wiley   +1 more source

The Prebiotic and Techno‐Functional Potential of Microbial Exopolysaccharides for Human Health and Food Systems

Comprehensive Reviews in Food Science and Food Safety, Volume 25, Issue 2, March 2026.
ABSTRACT Microbial exopolysaccharides (EPS) represent a diverse class of biopolymers holding considerable promise as functional food ingredients. This review analyzes the dual function of microbial EPS as a candidate for prebiotic agents and techno‐functional additives.
Md. Abdur Razzak, Hye Kim, Md. Ariful Haque, Min Ji Jang, Sehyeon Song, Anishka Talari, Lakshmi Devi Chittepu, Seockmo Ku   +7 more
wiley   +1 more source