FAS receptor regulates NOTCH activity through ERK-JAG1 axis activation and controls oral cancer stemness ability and pulmonary metastasis [PDF]
Cell Death Discovery, 2022 Pulmonary metastasis occurring via the colonization of circulating cancer stem cells is a major cause of oral squamous cell carcinoma (OSCC)-related death.
Li-Jie Li +9 more
doaj +2 more sources
The Fas/Fas ligand death receptor pathway contributes to phenylalanine-induced apoptosis in cortical neurons. [PDF]
PLoS ONE, 2013 Phenylketonuria (PKU), an autosomal recessive disorder of amino acid metabolism caused by mutations in the phenylalanine hydroxylase (PAH) gene, leads to childhood mental retardation by exposing neurons to cytotoxic levels of phenylalanine (Phe).
Xiaodong Huang +10 more
doaj +2 more sources
Fas and Fas ligand are highly expressed in lymphocytes from cervical intraepithelial neoplasia and cervical cancer patients: A possible role for immune escaping [PDF]
Iranian Journal of Basic Medical Sciences, 2022 Objective(s): Infection with high-risk human papillomavirus is required to develop cervical cancer. Some viruses modulate the Fas/FasL signaling to evade the immune response; the role of these molecules in cervical cancer is not clear.
Carla O Contreras-Ochoa +7 more
doaj +1 more source
Role of Apoptotic Biomarkers in Ameloblastoma and Dental Follicle
Journal of Dental School, 2021 Objectives Ameloblastoma is an odontogenic neoplasm with locally aggressive behavior. Fas and FasL play important roles in apoptotic pathways. The aim of this study was to determine the possible role of expression of apoptotic pathways (Fas and FasL) in
Fatemeh Mashhadiabbas +2 more
doaj +1 more source
Cells, 2022 Signaling through the TNF-family receptor Fas/CD95 can trigger apoptosis or non-apoptotic cellular responses and is essential for protection from autoimmunity.
Nicholas Frazzette +6 more
doaj +1 more source
Frontiers in Pediatrics, 2022 BackgroundThe autoimmune lymphoproliferative syndrome (ALPS) is a rare disease characterized by defective function of the FAS death receptor, which results in chronic, non-malignant lymphoproliferation and autoimmunity accompanied by elevated numbers of ...
Hao Gu +7 more
doaj +1 more source
Soluble Fas ligand drives autoantibody-induced arthritis by binding to DR5/TRAIL-R2
eLife, 2021 To date, no study has demonstrated that soluble Fas ligand (sFasL)-mediated inflammation is regulated via interaction with Fas in vivo. We found that FasL interacts specifically with tumor necrosis factor receptor superfamily (TNFRSF)10B, also known as ...
Dongjin Jeong +15 more
doaj +1 more source
Functional characterization of a chimeric soluble Fas ligand polymer with in vivo anti-tumor activity. [PDF]
PLoS ONE, 2013 Binding of ligand FasL to its receptor Fas triggers apoptosis via the caspase cascade. FasL itself is homotrimeric, and a productive apoptotic signal requires that FasL be oligomerized beyond the homotrimeric state. We generated a series of FasL chimeras
Sophie Daburon +13 more
doaj +1 more source
Pro- and anti-apoptotic fate decisions induced by di- and trimeric synthetic cytokine receptors
iScience, 2021 Summary: Synthetic strategies to activate cytokine receptors so far only address standard dimeric cytokine receptor assemblies. The 19 ligands of the tumor necrosis factor superfamily (TNFSF), however, form noncovalent trimers and receptor trimerization ...
Sofie Mossner +2 more
doaj +1 more source
The FAS-receptors of apoptosis expression on the medulloblastomas cells
Ukrainian Neurosurgical Journal, 2005 The Fas-receptor of apoptosis expression on the living medulloblastomas cells was determined. Fas-receptor of apoptosis was expressed on 4–48,8% tumors cells.
Yu. A. Orlov +5 more
doaj +1 more source