Virology, 2003 Hepatitis C virus (HCV) is remarkable for its ability to establish persistent infection. Studies suggest that HCV core protein modulates immune responses to viral infection and can bind Fas receptor in vitro. To further examine the role of HCV core protein in Fas signaling, full-length (aa 1-192) and truncated (aa 1-152) HCV core proteins were ...
Jonathan P Moorman +2 more
exaly +5 more sources
Engineering donor lymphocytes with Fas ligand protein effectively prevents acute graft-versus-host disease. [PDF]
Blood Adv, 2023 Abstract Alloreactive T-effector cells (Teffs) are the major culprit of acute graft-versus-host disease (aGVHD) associated with hematopoietic stem cell transplantation. Ex vivo nonspecific depletion of T cells from the donor graft impedes stem cell engraftment and posttransplant immune reconstitution.
Shrestha P +8 more
europepmc +3 more sources
CMTM6 suppresses cell-surface expression of death receptor FAS in mice but not in humans [PDF]
EMBO ReportsThe transmembrane protein CMTM6 promotes plasma membrane expression of the immune checkpoint protein PD-L1, a key suppressor of anti-tumor immunity. Targeting CMTM6 has been proposed as a strategy to enhance tumor cell killing by reducing PD-L1 surface ...
Tereza Semberova +9 more
doaj +2 more sources
Endocrine Journal, 2003 There are two local subtypes of extravillous trophoblast (EVT): one is the proliferative phenotype of EVT, which primarily consists of proximal cells and the other is the invasive phenotype of EVT, which is composed mainly of distal cells of cell columns. The mechanism of invasion of EVT to the decidua remains obscure.
Hiroya Matsuo +1 more
exaly +4 more sources
The role of Fas ligand protein in the oxidative stress induced by azoxymethane on crypt colon of rats O papel da proteína ligante Fas no estresse oxidativo induzido pelo azoximetano em criptas do colo de ratos [PDF]
Acta Cirúrgica Brasileira, 2010 PURPOSE: To study the protein Fas ligand (FasL) on the expression of apoptosis, using a model of oxidative stress induced by azoxymethane (AOM), in the crypt of colon in rats.
Luiz Antonio Maksoud Bussuan +4 more
doaj +5 more sources
Burden of novel and ultra-rare missense variants in the NF-κB pathway genes associated to Ménière’s disease [PDF]
Frontiers in ImmunologyIntroductionMénière's disease (MD) is an inner ear disorder characterised by tinnitus, sensorineural hearing loss and dizziness, although around 60% of patients also exhibit and immune dysregulation.
Pablo Cruz-Granados +11 more
doaj +2 more sources
EXPRESSION OF FAS PROTEIN (CD95) AND FAS LIGAND IN LIVER TISSUE OF PATIENTS WITH HCV-INDUCED CHRONIC LIVER DISEASE AND ITS CORRELATION WITH THE DISEASE PROGRESSION [PDF]
Journal of the Egyptian Society of Parasitology, 2013 This study evaluated hepatic expression of both Fas and Fas ligand (FasL) in patients with hepatitis c virus (HCV)-induced chronic liver disease and its correlation with the histopathological activity and laboratory parameters as an early predictorof ...
Y. EL-DESSOUKY +4 more
doaj +3 more sources
Role of Apoptotic Biomarkers in Ameloblastoma and Dental Follicle
Journal of Dental School, 2021 Objectives Ameloblastoma is an odontogenic neoplasm with locally aggressive behavior. Fas and FasL play important roles in apoptotic pathways. The aim of this study was to determine the possible role of expression of apoptotic pathways (Fas and FasL) in
Fatemeh Mashhadiabbas +2 more
doaj +1 more source
Fas and Fas ligand are highly expressed in lymphocytes from cervical intraepithelial neoplasia and cervical cancer patients: A possible role for immune escaping [PDF]
Iranian Journal of Basic Medical Sciences, 2022 Objective(s): Infection with high-risk human papillomavirus is required to develop cervical cancer. Some viruses modulate the Fas/FasL signaling to evade the immune response; the role of these molecules in cervical cancer is not clear.
Carla O Contreras-Ochoa +7 more
doaj +1 more source
Expression of Fas and Fas ligand protein and mRNA in mouse oocytes and embryos [PDF]
Reproduction, 2003 Abstract During mammalian embryonic development, abnormal eggs and embryos are eliminated by apoptosis; however, the precise apoptotic pathways remain as yet unidentified. In the present study, expression of Fas and Fas ligand - the proximal members of the death receptor pathway, was evaluated in mouse preimplantation embryos by ...
R L, Kelkar, S J, Dharma, T D, Nandedkar
openaire +2 more sources