Results 11 to 20 of about 107,401 (282)

p38 Mitogen-activated Protein Kinase Is Involved in Fas Ligand Expression [PDF]

Journal of Biological Chemistry, 1999
p38 mitogen-activated protein kinase (MAPK) is activated by T cell receptor engagement. Here we showed that T cell receptor activated p38alpha but not p38delta. Inhibition of p38alpha by the specific inhibitor SB 203580 prevented activation-induced cell death in T cells. SB 203580 had no effect on Fas-initiated apoptosis.
Hsu, S. C., Gavrilin, M. A., Tsai, M. H., Han, J. H., Lai, M. Z.   +4 more
openaire   +2 more sources

Ethanol-mediated alterations in oligodendrocyte differentiation in the developing brain

Neurobiology of Disease, 2021
Introduction: Alterations of white matter integrity and subsequent white matter structural deficits are consistent findings in Fetal Alcohol Syndrome (FAS), but knowledge regarding the molecular mechanisms underlying these abnormalities is incomplete ...
Nune Darbinian, Armine Darbinyan, Nana Merabova, Ahsun Bajwa, Gabriel Tatevosian, Diana Martirosyan, Huaqing Zhao, Michael E. Selzer, Laura Goetzl   +8 more
doaj   +1 more source

Soluble Fas and Soluble Fas Ligand Proteins in Human Milk: Possible Significance in the Development of Immunological Tolerance [PDF]

Scandinavian Journal of Immunology, 1999
Human milk contains a complex uncharacterized, immune system able to exert actions both locally and systemically. This study reports the results of an ELISA‐based quantitation of soluble Fas and soluble Fas ligand in human milk which may modulate the Fas/FasL system that is critical for the expression of immune tolerance and apoptosis.
M D, Srivastava, B I, Srivastava
openaire   +2 more sources

In Vivo Localization of Fas-Associated Death Domain Protein in the Nucleus and Cytoplasm of Normal Thyroid and Liver Cells [PDF]

, 2009
FADD (Fas-associated death domain) is the main death receptor adaptor molecule that transmits apoptotic signal. Recently, FADD protein was shown to be expressed both in the cytoplasm and nucleus of in vitro cell lines. In contrast to the cytoplasmic FADD,
Chiocchia, Gilles, Schmitt, Alain, Tourneur, Léa   +2 more
core   +5 more sources

Role of P38 Mitogen-Activated Protein Kinase Phosphorylation and Fas-Fas Ligand Interaction in Morphine-Induced Macrophage Apoptosis [PDF]

The Journal of Immunology, 2002
AbstractIn this study, we evaluated the molecular mechanisms involved in morphine-induced macrophage apoptosis. Both morphine and TGF-β promoted P38 mitogen-activated protein kinase (MAPK) phosphorylation, and this phosphorylation was inhibited by SB 202190 as well as by SB 203580.
Pravin C, Singhal, Madhu, Bhaskaran, Jaimita, Patel, Kalpesh, Patel, Balakuntalam S, Kasinath, Senthil, Duraisamy, Nicholas, Franki, Krishna, Reddy, Aditi A, Kapasi   +8 more
openaire   +2 more sources

Transfer of Fas (CD95) protein from the cell surface to the surface of polystyrene beads coated with anti-Fas antibody clone CH-11

European Journal of Histochemistry, 2010
Mouse monoclonal anti-Fas (CD95) antibody clone CH-11 has been widely used in research on apoptosis. CH-11 has the ability to bind to Fas protein on cell surface and induce apoptosis.
H. Sawai, N. Domae
doaj   +1 more source

Fas engagement induces the maturation of dendritic cells (DCs), the release of interleukin (IL)-1beta, and the production of interferon gamma in the absence of IL-12 during DC-T cell cognate interaction: a new role for Fas ligand in inflammatory responses [PDF]

, 2000
Ligation of the Fas (CD95) receptor leads to an apoptotic death signal in T cells, B cells, and macrophages. However, human CD34(+)-derived dendritic cells (DCs) and mouse DCs, regardless of their maturation state, are not susceptible to Fas-induced cell
Alderson, Allison, Arrighi, Ashany, Ashany, Banchereau, Barbara Valzasina, Chervonsky, Citterio, De Maria, De Smedt, Holler, Iezzi, Irmler, Jurg Tschopp, Kataoka, Kennedy, Lars French, Lynch, Maria Rescigno, Matsue, Miwa, Paola Ricciardi-Castagnoli, Piguet, Rescigno, Richardson, Rothstein, Rudolf Zubler, Schmid, Stassi, Suda, Suzanne Lens, Takahashi, Tschopp, Vincent Kindler, Vincent Piguet, Willems, Winzler   +37 more
core   +1 more source

Pigment Epithelial-derived Factor (PEDF)-triggered Lung Cancer Cell Apoptosis Relies on p53 Protein-driven Fas Ligand (Fas-L) Up-regulation and Fas Protein Cell Surface Translocation [PDF]

Journal of Biological Chemistry, 2014
Pigment epithelium-derived factor (PEDF), a potent antiangiogenesis agent, has recently attracted attention for targeting tumor cells in several types of tumors. However, less is known about the apoptosis-inducing effect of PEDF on human lung cancer cells and the underlying molecular events.
Lei, Li, Ya-Chao, Yao, Shu-Huan, Fang, Cai-Qi, Ma, Yi, Cen, Zu-Min, Xu, Zhi-Yu, Dai, Cen, Li, Shuai, Li, Ting, Zhang, Hong-Hai, Hong, Wei-Wei, Qi, Ti, Zhou, Chao-Yang, Li, Xia, Yang, Guo-Quan, Gao   +15 more
openaire   +2 more sources

Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening

BMC Immunology, 2009
Background - Fas ligand is a cytotoxic effector molecule of T and NK cells which is characterized by an intracellular N-terminal polyproline region that serves as a docking site for SH3 and WW domain proteins.
Lettau Marcus, Voss Matthias, Janssen Ottmar   +2 more
doaj   +1 more source

Effect of adjuvant therapy with ginkgo-damole on apoptosis, nerve injury and platelet aggregation of patients with acute cerebral infarction

Journal of Acute Disease, 2017
Objective: To investigate the effect of adjuvant therapy with ginkgo-damole on apoptosis, nerve injury and platelet aggregation of patients with acute cerebral infarction.
Zhi-Yong Lu
doaj   +1 more source