Results 11 to 20 of about 58,729 (255)
FAS-dependent cell death in α-synuclein transgenic oligodendrocyte models of multiple system atrophy. [PDF]
PLoS ONE, 2013 Multiple system atrophy is a parkinsonian neurodegenerative disorder. It is cytopathologically characterized by accumulation of the protein p25α in cell bodies of oligodendrocytes followed by accumulation of aggregated α-synuclein in so-called glial ...
Christine L Kragh +12 more
doaj +3 more sources
European Journal of Histochemistry, 2010 Mouse monoclonal anti-Fas (CD95) antibody clone CH-11 has been widely used in research on apoptosis. CH-11 has the ability to bind to Fas protein on cell surface and induce apoptosis.
H. Sawai, N. Domae
doaj +3 more sources
Deregulation of Fas ligand expression as a novel cause of autoimmune lymphoproliferative syndrome-like disease [PDF]
Haematologica, 2015 Autoimmune lymphoproliferative syndrome is frequently caused by mutations in genes involved in the Fas death receptor pathway, but for 20–30% of patients the genetic defect is unknown.
Schafiq Nabhani +13 more
doaj +2 more sources
Fas and Fas ligand protein and mRNA in normal and atretic mouse ovarian follicles [PDF]
Reproduction, 2003 Abstract Apoptosis is the underlying mechanism of follicular atresia in the mammalian ovary. However, the apoptotic pathways governing this ovarian process are not completely elucidated. In the present study, expression of Fas and Fas ligand, the proximal members of the death receptor pathway, was evaluated in mouse ovarian follicles ...
S J, Dharma, R L, Kelkar, T D, Nandedkar
openaire +2 more sources
Cells, 2022 Signaling through the TNF-family receptor Fas/CD95 can trigger apoptosis or non-apoptotic cellular responses and is essential for protection from autoimmunity.
Nicholas Frazzette +6 more
doaj +1 more source
The Critical Role of Protein Kinase C-θ in Fas/Fas Ligand-Mediated Apoptosis [PDF]
The Journal of Immunology, 2007 Abstract A functional immune system not only requires rapid expansion of antigenic specific T cells, but also requires efficient deletion of clonally expanded T cells to avoid accumulation of T cells. Fas/Fas ligand (FasL)-mediated apoptosis plays a critical role in the deletion of activated peripheral T cells, which is clearly ...
Santhakumar, Manicassamy, Zuoming, Sun
openaire +2 more sources
Soluble Fas and Soluble Fas Ligand Proteins in Human Milk: Possible Significance in the Development of Immunological Tolerance [PDF]
Scandinavian Journal of Immunology, 1999 Human milk contains a complex uncharacterized, immune system able to exert actions both locally and systemically. This study reports the results of an ELISA‐based quantitation of soluble Fas and soluble Fas ligand in human milk which may modulate the Fas/FasL system that is critical for the expression of immune tolerance and apoptosis.
M D, Srivastava, B I, Srivastava
openaire +2 more sources
p38 Mitogen-activated Protein Kinase Is Involved in Fas Ligand Expression [PDF]
Journal of Biological Chemistry, 1999 p38 mitogen-activated protein kinase (MAPK) is activated by T cell receptor engagement. Here we showed that T cell receptor activated p38alpha but not p38delta. Inhibition of p38alpha by the specific inhibitor SB 203580 prevented activation-induced cell death in T cells. SB 203580 had no effect on Fas-initiated apoptosis.
Hsu, S. C. +4 more
openaire +2 more sources
Ethanol-mediated alterations in oligodendrocyte differentiation in the developing brain
Neurobiology of Disease, 2021 Introduction: Alterations of white matter integrity and subsequent white matter structural deficits are consistent findings in Fetal Alcohol Syndrome (FAS), but knowledge regarding the molecular mechanisms underlying these abnormalities is incomplete ...
Nune Darbinian +8 more
doaj +1 more source
Hepatology, EarlyView., 2022 Graphical summary of obesity‐induced NASH progression by LCN2 targeted to HSC activation. Abstract Background and Aims In obesity and type 2 diabetes mellitus, leptin promotes insulin resistance and contributes to the progression of NASH via activation of hepatic stellate cells (HSCs).
Kyung Eun Kim +12 more
wiley +1 more source