Decidual Macrophages Are Significantly Increased in Spontaneous Miscarriages and Over-Express FasL [PDF]
, 2012 Decidual macrophages (DM) are the second most abundant population in the fetal-maternal interface. Their role has been so far identified as being local immuno-modulators favoring the maternal tolerance to the fetus.
Iordanis Navrozoglou +21 more
core +1 more source
Alteration of Regulation of Fas/FasL Mediated Apoptosis in Gastric Cancer [PDF]
Revista Ciencias de la Salud, 2009 Gastric cancer is an important neoplasticdisease in all around the world because its highincidence and mortality. Otherwise, apoptosis isa key process of programmed cell death duringembryogenesis, regulation of immune system,and holding the tissue ...
Reggie García Robles +2 more
doaj
BMC Biotechnology, 2017 Background Fas ligand plays a key role in the human immune system as a major cell death inducing protein. The extracellular domain of human Fas ligand (hFasLECD) triggers apoptosis of malignant cells, and therefore is expected to have substantial ...
Michiro Muraki, Kiyonori Hirota
doaj +1 more source
FLASH knockdown sensitizes cells to Fas-mediated apoptosis via down-regulation of the anti-apoptotic proteins, MCL-1 and Cflip short. [PDF]
PLoS ONE, 2012 FLASH (FLICE-associated huge protein or CASP8AP2) is a large multifunctional protein that is involved in many cellular processes associated with cell death and survival.
Song Chen +2 more
doaj +1 more source
Fas activates lipolysis in a Ca2+-CaMKII-dependent manner in 3T3-L1 adipocytes[S]
Journal of Lipid Research, 2013 Fas (CD95) is a member of the tumor necrosis factor (TNF) receptor superfamily and plays a crucial role in the induction of apoptosis. However, like TNF, Fas can induce nonapoptotic signaling pathways.
Reto A. Rapold +4 more
doaj +1 more source
Apoptosis and upregulation of TNF-α and TRAIL receptor 1 (DR4) in the pathogenesis of food protein-induced enterocolitis syndrome [PDF]
Korean Journal of Pediatrics, 2010 Purpose : Expression levels of tumor necrosis factor (TNF)-?#6181;xpression on the mucosa of the small intestine is increased in patients with villous atrophy in food protein-induced enterocolitis syndrome (FPIES).
Jin-Bok Hwang +5 more
doaj +1 more source
Soluble Fas ligand drives autoantibody-induced arthritis by binding to DR5/TRAIL-R2
eLife, 2021 To date, no study has demonstrated that soluble Fas ligand (sFasL)-mediated inflammation is regulated via interaction with Fas in vivo. We found that FasL interacts specifically with tumor necrosis factor receptor superfamily (TNFRSF)10B, also known as ...
Dongjin Jeong +15 more
doaj +1 more source
Blood, 2010 AbstractAutoimmunity is a surprisingly common complication of primary immunodeficiencies, yet the molecular mechanisms underlying this clinical observation are not well understood. One widely known example is provided by Wiskott-Aldrich syndrome (WAS), an X-linked primary immunodeficiency disorder caused by mutations in the gene encoding the WAS ...
Nikolay P, Nikolov +8 more
openaire +3 more sources
Fas ligand is differentially expressed in a hepatosplenic T-cell lymphoma cell line.
, 2021 Hepatosplenic T-cell lymphoma is an aggressive cancer of T-cells that has a median survival of 8 months (1). A hallmark of cancer cells is dysregulation of survival signaling (2).
Shahan Mamoor
core +1 more source
The adaptor protein Nck interacts with Fas ligand: Guiding the death factor to the cytotoxic immunological synapse [PDF]
Proceedings of the National Academy of Sciences, 2006 The Fas ligand (FasL) is a key death factor of cytotoxic T lymphocytes and natural killer cells. It is stored intracellularly as a transmembrane protein of secretory lysosomes. Upon activation, these vesicles are transported to the cytotoxic immunological synapse (IS), and FasL becomes exposed to the cell surface to trigger cell death through ligation ...
Marcus, Lettau +6 more
openaire +2 more sources