Regulation of fibroblast Fas expression by soluble and mechanical pro-fibrotic stimuli
Respiratory Research, 2018 Background Fibroblast apoptosis is a critical component of normal repair and the acquisition of an apoptosis-resistant phenotype contributes to the pathogenesis of fibrotic repair. Fibroblasts from fibrotic lungs of humans and mice demonstrate resistance
Amos E. Dodi +9 more
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The transmembrane domains of TNF-related apoptosis-inducing ligand (TRAIL) receptors 1 and 2 co-regulate apoptotic signaling capacity. [PDF]
PLoS ONE, 2012 TNF-related apoptosis-inducing ligand (TRAIL) is a member of the tumor necrosis factor (TNF) ligand family that exerts its apoptotic activity in human cells by binding to two transmembrane receptors, TRAILR1 and TRAILR2.
Simon Neumann +5 more
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Calcium alleviates fluoride-induced kidney damage via FAS/FASL, TNFR/TNF, DR5/TRAIL pathways in rats
Ecotoxicology and Environmental Safety, 2021 Long-term excessive intake of fluoride (F) can cause osseous and non-osseous damage. The kidney is the main fluoride excretion organ of the body. This study aimed to explore whether dietary calcium (Ca) supplementation can alleviate kidney damage caused ...
Haojie Li +8 more
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Gossypin attenuates methotrexate-induced nephrotoxicity: Role of COX II/MMP-9 and fas ligand. [PDF]
Minia Journal of Medical Research, 2020 Methotrexate (MTX) is one of commonly used chemotherapeutic drugs, with well-known nephrotoxic effect. This study aimed to investigate the protective mechanisms of gossypin; a bioflavonoid present in plants, against MTX-induced nephrotoxicity.
Nagwa Zenhom, Azza El-Sheikh, Heba Hafez
doaj +1 more source
PMA and ionomycin induce glioblastoma cell death: activation-induced cell-death-like phenomena occur in glioma cells. [PDF]
PLoS ONE, 2013 Phorbol myristate acetate (PMA) and ionomycin (Io) can induce T cell activation and proliferation. Furthermore, they stimulate activation-induced cell death (AICD) in mature lymphocytes via Fas/Fas ligand (FasL) up-regulation.
Sheng Han +4 more
doaj +1 more source
Blood, 2010 AbstractAutoimmunity is a surprisingly common complication of primary immunodeficiencies, yet the molecular mechanisms underlying this clinical observation are not well understood. One widely known example is provided by Wiskott-Aldrich syndrome (WAS), an X-linked primary immunodeficiency disorder caused by mutations in the gene encoding the WAS ...
Nikolay P, Nikolov +8 more
openaire +3 more sources
Effector and naturally occurring regulatory T cells display no abnormalities in activation induced cell death in NOD mice. [PDF]
PLoS ONE, 2011 BACKGROUND: Disturbed peripheral negative regulation might contribute to evolution of autoimmune insulitis in type 1 diabetes. This study evaluates the sensitivity of naïve/effector (Teff) and regulatory T cells (Treg) to activation-induced cell death ...
Ayelet Kaminitz +6 more
doaj +1 more source
Apoptosis Transcriptional Profile Induced by Porphyromonas gingivalis HmuY
Mediators of Inflammation, 2019 This study aimed at evaluating the transcriptional profile of apoptosis-related genes after in vitro stimulation of peripheral blood mononuclear cells (PBMCs) derived from individuals with periodontitis (P) and healthy nonperiodontitis (NP) control ...
Paulo C. Carvalho-Filho +12 more
doaj +1 more source
Intrahepatic mRNA Expression of FAS, FASL, and FOXP3 Genes Is Associated with the Pathophysiology of Chronic HCV Infection. [PDF]
PLoS ONE, 2016 UNLABELLED:This study aimed to evaluate the relative mRNA expression of Fas receptor (FAS), Fas ligand (FASL), and forkhead box protein 3 (FOXP3) in liver biopsy specimens obtained from patients with viral and non-viral chronic hepatitis and correlate ...
Ednelza da Silva Graça Amoras +10 more
doaj +1 more source
The adaptor protein Nck interacts with Fas ligand: Guiding the death factor to the cytotoxic immunological synapse [PDF]
Proceedings of the National Academy of Sciences, 2006 The Fas ligand (FasL) is a key death factor of cytotoxic T lymphocytes and natural killer cells. It is stored intracellularly as a transmembrane protein of secretory lysosomes. Upon activation, these vesicles are transported to the cytotoxic immunological synapse (IS), and FasL becomes exposed to the cell surface to trigger cell death through ligation ...
Marcus, Lettau +6 more
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