Results 51 to 60 of about 107,401 (282)

Soluble Fas ligand drives autoantibody-induced arthritis by binding to DR5/TRAIL-R2

eLife, 2021
To date, no study has demonstrated that soluble Fas ligand (sFasL)-mediated inflammation is regulated via interaction with Fas in vivo. We found that FasL interacts specifically with tumor necrosis factor receptor superfamily (TNFRSF)10B, also known as ...
Dongjin Jeong, Hye Sung Kim, Hye Young Kim, Min Jueng Kang, Hyeryeon Jung, Yumi Oh, Donghyun Kim, Jaemoon Koh, Sung-Yup Cho, Yoon Kyung Jeon, Eun Bong Lee, Seung Hyo Lee, Eui-Cheol Shin, Ho Min Kim, Eugene C Yi, Doo Hyun Chung   +15 more
doaj   +1 more source

Inhibition of death receptor signals by cellular FLIP. [PDF]

, 1997
The widely expressed protein Fas is a member of the tumour necrosis factor receptor family which can trigger apoptosis. However, Fas surface expression does not necessarily render cells susceptible to Fas ligand-induced death signals, indicating that ...
Bodmer, J.L., Burns, K., French, L.E., Hahne, M., Hofmann, K., Irmler, M., Mattmann, C., Rimoldi, D., Schneider, P., Schröter, M., Steiner, V., Thome, M., Tschopp, J.   +12 more
core   +1 more source

Apoptosis and apoptosis-related proteins (Fas, Fas ligand, bcl-2, p53) in macrophages of human ovarian epithelial tumors.

European journal of gynaecological oncology, 2000
Apoptosis and the apoptosis-related proteins (ARP) (Fas, Fas ligand (FasL), bcl-2 and p53) were analyzed in macrophages of different human ovarian epithelial tumors. Few macrophages were found in ovaries of women without oncologic disorders. In ovarian benign cysts, macrophagic density reached 4.9+/-1.2 per 50,000 microm2, most were present in lymphoid-
H, Ben-Hur, P, Gurevich, A, Ben-Arie, M, Huszar, V, Berman, Y, Tendler, R, Tchanishev, G, Mor, S, Gershon, I, Zusman   +9 more
openaire   +2 more sources

Sh3bp2 Gain-Of-Function Mutation Ameliorates Lupus Phenotypes in B6.MRL-Faslpr Mice [PDF]

, 2019
SH3 domain-binding protein 2 (SH3BP2) is an adaptor protein that is predominantly expressed in immune cells, and it regulates intracellular signaling. We had previously reported that a gain-of-function mutation in SH3BP2 exacerbates inflammation and bone
Iseki, Masanori, Ishihara, Katsuhiko, Kashihara, Naoki, Kawahara, Kyoko, Morita, Yoshitaka, Mukai, Tomoyuki, Nagasu, Akiko, Nagasu, Hajime, Tsuji, Shoko, Ueki, Yasuyoshi   +9 more
core   +1 more source

Lifeguard/neuronal membrane protein 35 regulates Fas ligand‐mediated apoptosis in neurons via microdomain recruitment [PDF]

Journal of Neurochemistry, 2007
AbstractFas ligand (FasL)‐receptor system plays an essential role in regulating cell death in the developing nervous system, and it has been implicated in neurodegenerative and inflammatory responses in the CNS. Lifeguard (LFG) is a protein highly expressed in the hippocampus and the cerebellum, and it shows a particularly interesting regulation by ...
Miriam, Fernández, Miguel F, Segura, Carme, Solé, Alicia, Colino, Joan X, Comella, Valentín, Ceña   +5 more
openaire   +2 more sources

Marked mitigation of transplant vascular sclerosis in FasL(gld) (CD95L) mutant recipients. I. The role of alloantibodies in the development of chronic rejection [PDF]

, 1999
Background. In the acute rejection of allografts, the interaction between Fas (CD95) and its ligand (FasL; CD95L) has been shown to be involved in mediating apoptotic cell death.
Aitouche, A, Fung, JJ, Rao, AS, Salam, A, Starzl, TE, Subbotin, V, Sun, H, Valdivia, LA   +7 more
core   +1 more source

Cyclic Olefin Copolymers as Versatile Materials for Advanced Engineering Applications

Advanced Functional Materials, EarlyView.
Cyclic olefin copolymers (COCs) are presented as highly versatile materials combining tunable synthesis, excellent optical properties, and mechanical robustness. Their potential spans microfluidics, bioengineering, and advanced electronics, while emerging self‐healing and sustainable solutions highlight future opportunities.
Giulia Fredi, Norma Mallegni, Andrea Dorigato, Mario Milazzo   +3 more
wiley   +1 more source

Fatty Acid Binding to Human Serum Albumin in Blood Serum Characterized by EPR Spectroscopy

ChemistryOpen, 2019
One of the functions of Human Serum Albumin (HSA) is binding and transport of fatty acids. This ability could be altered by the presence of several blood components such as toxins or peptides – which in turn alters the functionality of the protein.
Dr. Haleh H. Haeri, Bettina Schunk, Jörg Tomaszewski, Heike Schimm, Dr. Marcos J. Gelos, Prof. Dr. Dariush Hinderberger   +5 more
doaj   +1 more source

Regulation of fibroblast Fas expression by soluble and mechanical pro-fibrotic stimuli

Respiratory Research, 2018
Background Fibroblast apoptosis is a critical component of normal repair and the acquisition of an apoptosis-resistant phenotype contributes to the pathogenesis of fibrotic repair. Fibroblasts from fibrotic lungs of humans and mice demonstrate resistance
Amos E. Dodi, Iyabode O. Ajayi, Christine Chang, Meghan Beard, Shanna L. Ashley, Steven K. Huang, Victor J. Thannickal, Daniel J. Tschumperlin, Thomas H. Sisson, Jeffrey C. Horowitz   +9 more
doaj   +1 more source

The transmembrane domains of TNF-related apoptosis-inducing ligand (TRAIL) receptors 1 and 2 co-regulate apoptotic signaling capacity. [PDF]

PLoS ONE, 2012
TNF-related apoptosis-inducing ligand (TRAIL) is a member of the tumor necrosis factor (TNF) ligand family that exerts its apoptotic activity in human cells by binding to two transmembrane receptors, TRAILR1 and TRAILR2.
Simon Neumann, Tobias Bidon, Marcus Branschädel, Anja Krippner-Heidenreich, Peter Scheurich, Malgorzata Doszczak   +5 more
doaj   +1 more source