Results 51 to 60 of about 57,038 (163)

FAS mediates apoptosis, inflammation, and treatment of pathogen infection

Frontiers in Cellular and Infection Microbiology
The FAS cell surface death receptor, a member of the tumor necrosis factor receptor family, activates both apoptotic and non-apoptotic signaling upon interaction with its ligand FASL.
Liying Hu, Liying Hu, Juane Lu, Juane Lu, Hongfei Fan, Changcheng Niu, Changcheng Niu, Yanping Han, Yanping Han, Qinggele Caiyin, Qinggele Caiyin, Qinggele Caiyin, Hao Wu, Jianjun Qiao, Jianjun Qiao, Jianjun Qiao, Jianjun Qiao   +16 more
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Listeria monocytogenes virulence proteins induce surface expression of Fas ligand on T lymphocytes [PDF]

Molecular Microbiology, 2004
SummaryVirulence factors secreted by Listeria monocytogenes are known to interfere with host cellular signalling pathways. We investigated whether L. monocytogenes modulates T‐cell receptor signalling by examining surface expression of proteins known to be upregulated on activated T cells. In vitro culture of murine splenocytes with L.
Lauren A, Zenewicz, Jason A, Skinner, Howard, Goldfine, Hao, Shen   +3 more
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The LXR ligand T0901317 induces severe lipogenesis in the db/db diabetic mouse

Journal of Lipid Research, 2003
Liver X receptor (LXR) ligands are currently being evaluated as potential therapeutic agents for the treatment of low HDL. The LXR ligand T0901317 elevates ATP binding cassette transporter A1 (ABCA1) and HDL levels in animal models and induces moderate ...
Jeffrey W. Chisholm, Jenny Hong, Scott A. Mills, Richard M. Lawn   +3 more
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Fluoride resistance in fibroblasts is conferred via reduced susceptibility to oxidative stress and apoptosis

FEBS Open Bio, 2020
Chronic fluoride exposure from drinking water may result in endemic fluorosis. To better understand the mechanisms by which some people are resistant to fluorosis, here we investigated the effect of treatment with NaF (sodium fluoride) on production of ...
Jing Ni, Zhe Zhong, Wu Zhang, Bin Liu, Rong Shu, Yiming Li   +5 more
doaj   +1 more source

Protective Effect of Vitamin D against Hepatic Molecular Apoptosis Caused by a High-Fat Diet in Rats

Current Issues in Molecular Biology, 2023
The protective effects of vitamin D (VitD) in different diseases were studied. The liver is of great interest, especially with the presence of VitD receptors. A high-fat diet (HFD) is associated with many diseases, including liver injury.
Huda F. Alshaibi, Sherin Bakhashab, Asma Almuhammadi, Yusuf S. Althobaiti, Mohammed A. Baghdadi, Khadeejah Alsolami   +5 more
doaj   +1 more source

HIV Tat Binds Egr Proteins and Enhances Egr-dependent Transactivation of the Fas Ligand Promoter [PDF]

Journal of Biological Chemistry, 2002
HIV Tat can enhance activation-induced up-regulation of Fas ligand (FasL), which may contribute to T cell apoptosis in human immune deficiency virus (HIV)-infected individuals. We have assessed functional and physical interactions between Tat and the Egr family of transcription factors (Egr-1, -2, and -3), the latter two of which are major participants
Yili, Yang, Bei, Dong, Paul R, Mittelstadt, Hua, Xiao, Jonathan D, Ashwell   +4 more
openaire   +2 more sources

TRAIL receptor signaling regulation of chemosensitivity in vivo but not in vitro. [PDF]

PLoS ONE, 2011
Signaling by Tumor Necrosis Factor-Related Apoptosis Inducing Ligand (TRAIL) and Fas ligand (FasL) has been proposed to contribute to the chemosensitivity of tumor cells treated with various other anti-cancer agents.
Christina Menke, Tatiana Goncharov, Lubna Qamar, Christopher Korch, Heide L Ford, Kian Behbakht, Andrew Thorburn   +6 more
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Pigment Epithelial-derived Factor (PEDF)-triggered Lung Cancer Cell Apoptosis Relies on p53 Protein-driven Fas Ligand (Fas-L) Up-regulation and Fas Protein Cell Surface Translocation [PDF]

Journal of Biological Chemistry, 2014
Pigment epithelium-derived factor (PEDF), a potent antiangiogenesis agent, has recently attracted attention for targeting tumor cells in several types of tumors. However, less is known about the apoptosis-inducing effect of PEDF on human lung cancer cells and the underlying molecular events.
Lei, Li, Ya-Chao, Yao, Shu-Huan, Fang, Cai-Qi, Ma, Yi, Cen, Zu-Min, Xu, Zhi-Yu, Dai, Cen, Li, Shuai, Li, Ting, Zhang, Hong-Hai, Hong, Wei-Wei, Qi, Ti, Zhou, Chao-Yang, Li, Xia, Yang, Guo-Quan, Gao   +15 more
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Babao Dan induces gastric cancer cell apoptosis via regulating MAPK and NF-κB signaling pathways

Journal of International Medical Research, 2019
Objective The objective was to further investigate apoptosis induction by Babao Dan (BBD), which supports its anti-tumor mechanisms, using two human gastric cancer cell lines (AGS and MGC80-3).
Haixia Shang, Zhiyun Cao, Jinyan Zhao, Jianhua Guan, Jianxin Liu, Jun Peng, Youqin Chen, Thomas Joseph Sferra, Senthilkumar Sankararaman, Jiumao Lin   +9 more
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The extracellular matrix, p53 and estrogen compete to regulate cell-surface Fas/Apo-1 suicide receptor expression in proliferating embryonic cerebral cortical precursors, and reciprocally, Fas-ligand modifies estrogen control of cell-cycle proteins

BMC Neuroscience, 2004
Background Apoptosis is important for normal cerebral cortical development. We previously showed that the Fas suicide receptor was expressed within the developing cerebral cortex, and that in vitro Fas activation resulted in caspase-dependent death ...
Newman Joseph M, Wade Stephen B, Santillano Daniel R, Cheema Zulfiqar F, Miranda Rajesh C   +4 more
doaj   +1 more source