Results 51 to 60 of about 58,729 (255)

C-Jun N-terminal kinases/c-Jun and p38 pathways cooperate in ceramide-induced neuronal apoptosis [PDF]

, 2003
Understanding the regulation of the apoptotic program in neurons by intracellular pathways is currently a subject of great interest. Recent results suggest that c-Jun N-terminal kinases (JNK), mitogen-activated protein kinases and the transcription ...
Brugg, B., Caboche, J., Willaime-Morawek, S., Brami-Cherrier, K., Mariani, J.   +4 more
core   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Fatty Acid Binding to Human Serum Albumin in Blood Serum Characterized by EPR Spectroscopy

ChemistryOpen, 2019
One of the functions of Human Serum Albumin (HSA) is binding and transport of fatty acids. This ability could be altered by the presence of several blood components such as toxins or peptides – which in turn alters the functionality of the protein.
Dr. Haleh H. Haeri, Bettina Schunk, Jörg Tomaszewski, Heike Schimm, Dr. Marcos J. Gelos, Prof. Dr. Dariush Hinderberger   +5 more
doaj   +1 more source

Regulation of fibroblast Fas expression by soluble and mechanical pro-fibrotic stimuli

Respiratory Research, 2018
Background Fibroblast apoptosis is a critical component of normal repair and the acquisition of an apoptosis-resistant phenotype contributes to the pathogenesis of fibrotic repair. Fibroblasts from fibrotic lungs of humans and mice demonstrate resistance
Amos E. Dodi, Iyabode O. Ajayi, Christine Chang, Meghan Beard, Shanna L. Ashley, Steven K. Huang, Victor J. Thannickal, Daniel J. Tschumperlin, Thomas H. Sisson, Jeffrey C. Horowitz   +9 more
doaj   +1 more source

The transmembrane domains of TNF-related apoptosis-inducing ligand (TRAIL) receptors 1 and 2 co-regulate apoptotic signaling capacity. [PDF]

PLoS ONE, 2012
TNF-related apoptosis-inducing ligand (TRAIL) is a member of the tumor necrosis factor (TNF) ligand family that exerts its apoptotic activity in human cells by binding to two transmembrane receptors, TRAILR1 and TRAILR2.
Simon Neumann, Tobias Bidon, Marcus Branschädel, Anja Krippner-Heidenreich, Peter Scheurich, Malgorzata Doszczak   +5 more
doaj   +1 more source

Calcium alleviates fluoride-induced kidney damage via FAS/FASL, TNFR/TNF, DR5/TRAIL pathways in rats

Ecotoxicology and Environmental Safety, 2021
Long-term excessive intake of fluoride (F) can cause osseous and non-osseous damage. The kidney is the main fluoride excretion organ of the body. This study aimed to explore whether dietary calcium (Ca) supplementation can alleviate kidney damage caused ...
Haojie Li, Junjiang Fan, Yangfei Zhao, Jiarong Yang, Huimiao Xu, Ram Kumar Manthari, Xiaofang Cheng, Jundong Wang, Jinming Wang   +8 more
doaj   +1 more source

Listeria monocytogenes virulence proteins induce surface expression of Fas ligand on T lymphocytes [PDF]

Molecular Microbiology, 2004
SummaryVirulence factors secreted by Listeria monocytogenes are known to interfere with host cellular signalling pathways. We investigated whether L. monocytogenes modulates T‐cell receptor signalling by examining surface expression of proteins known to be upregulated on activated T cells. In vitro culture of murine splenocytes with L.
Lauren A, Zenewicz, Jason A, Skinner, Howard, Goldfine, Hao, Shen   +3 more
openaire   +2 more sources

Uterine spiral artery remodeling involves endothelial apoptosis induced by extravillous trophoblasts through Fas/FasL interactions.

, 2005
Objective— Invasion of uterine spiral arteries by extravillous trophoblasts in the first trimester of pregnancy results in loss of endothelial and musculoelastic layers.
Philip R. Dash, Cartwright, JE, Whitley, GS, Ashton, SV, Philip N. Baker, Crocker, IP, Baker, PN, Guy St. J. Whitley, Ian P. Crocker, Mark Wareing, Wareing, M, Sandra V. Ashton, Judith E. Cartwright, Dash, PR   +13 more
core   +1 more source

Streptavidins Coordinate Biotin Sequestration and Self‐Resistance Within a Biotin‐Pathway Antibiotic Network

Advanced Science, EarlyView.
A conserved genomic region between two streptavidin genes in Streptomyces packages biosynthetic gene clusters for diverse biotin‐pathway antibiotics: acidomycin, stravidin, the new non‐proteinogenic amino acid ANDA, and the new BioA inhibitor α‐methyl‐KAPA.
Sumire Kurosawa, Jingjun Mo, Xiaotong Diao, Feng Xie, Tingting Wang, Haowen Zhao, Dalei Wu, Rolf Müller, Chengzhang Fu   +8 more
wiley   +1 more source

Gossypin attenuates methotrexate-induced nephrotoxicity: Role of COX II/MMP-9 and fas ligand. [PDF]

Minia Journal of Medical Research, 2020
Methotrexate (MTX) is one of commonly used chemotherapeutic drugs, with well-known nephrotoxic effect. This study aimed to investigate the protective mechanisms of gossypin; a bioflavonoid present in plants, against MTX-induced nephrotoxicity.
Nagwa Zenhom, Azza El-Sheikh, Heba Hafez
doaj   +1 more source