Results 71 to 80 of about 107,401 (282)

Effector and naturally occurring regulatory T cells display no abnormalities in activation induced cell death in NOD mice. [PDF]

PLoS ONE, 2011
BACKGROUND: Disturbed peripheral negative regulation might contribute to evolution of autoimmune insulitis in type 1 diabetes. This study evaluates the sensitivity of naïve/effector (Teff) and regulatory T cells (Treg) to activation-induced cell death ...
Ayelet Kaminitz, Esma S Yolcu, Enosh M Askenasy, Jerry Stein, Isaac Yaniv, Haval Shirwan, Nadir Askenasy   +6 more
doaj   +1 more source

Overexpression of Mcl-1 exacerbates lymphocyte accumulation and autoimmune kidney disease in lpr mice [PDF]

, 2016
Cell death by apoptosis has a critical role during embryonic development and in maintaining tissue homeostasis. In mammals, there are two converging apoptosis pathways: the ‘extrinsic’ pathway, which is triggered by engagement of cell surface ‘death ...
A Egle, A Enders, A Strasser, A Strasser, A Strasser, A Strasser, A Strasser, A Strasser, A Villunger, AE Weant, AR Delbridge, BA Croker, Cassandra J Vandenberg, DA Hildeman, DA Steimer, E Lagasse, E Schneider, EA Reap, EM Carrington, F Rieux-Laucat, GH Fisher, I Dzhagalov St, I Vikstrom, IN Lavrik, J Hutcheson, J Opferman, JI Fletcher, JJ Weening, JM Brouwer, JT Opferman, K Fecho, K Iwai, K Nakayama, KA Fortner, KD Mason, Kirsteen J Campbell, KJ Campbell, KL O'Neill, L Chen, Lorraine A O’Reilly, M Pellegrini, MN Martina, Natasha S Anstee, P Bouillet, P Hughes, PD Hughes, PE Czabotar, PE Czabotar, Peter D Hughes, PH Krammer, PL Cohen, R Watanabe-Fukunaga, RM Perciavalle, S Cory, S Ogilvy, SF Fischer, SN Willis, SN Willis, Suzanne Cory, T Kuwana, T Moldoveanu, TH Price, TJ McDonnell, V Peperzak, WC Liles, WF Davidson   +65 more
core   +3 more sources

ECM‐Stiffness Mediated Persistent Fibroblast Activation Requires Integrin and Formin Dependent Chromatin Remodeling

Advanced Science, EarlyView.
Prolonged exposure to stiff extracellular matrix drives cancer‐associated fibroblasts into a persistently activated myofibroblast state. Two parallel pathways are identified: β1 integrin activation smoothens the nuclear lamina to reduce lamin–chromatin contacts, while the formin mDia2 regulates nuclear actin to alter chromatin organization.
Swathi Packirisamy, Oscar André, Zhimeng Fan, Pontus Nordenfelt, Vinay S Swaminathan   +4 more
wiley   +1 more source

Intrahepatic mRNA Expression of FAS, FASL, and FOXP3 Genes Is Associated with the Pathophysiology of Chronic HCV Infection. [PDF]

PLoS ONE, 2016
UNLABELLED:This study aimed to evaluate the relative mRNA expression of Fas receptor (FAS), Fas ligand (FASL), and forkhead box protein 3 (FOXP3) in liver biopsy specimens obtained from patients with viral and non-viral chronic hepatitis and correlate ...
Ednelza da Silva Graça Amoras, Samara Tatielle Monteiro Gomes, Felipe Bonfim Freitas, Bárbara Brasil Santana, Geraldo Ishak, Marialva Tereza Ferreira de Araújo, Sâmia Demachki, Simone Regina Souza da Silva Conde, Marluísa de Oliveira Guimarães Ishak, Ricardo Ishak, Antonio Carlos Rosário Vallinoto   +10 more
doaj   +1 more source

lHuman cytotoxic T lymphocytes with reduced sensitivity to Fas-induced apoptosis [PDF]

, 2005
Effector-memory T cells expressing Fas (Apo-1/CD95) are switched to an apoptotic program by cross-linking with Fas-ligand (FasL). Consequently, tumors that express FasL can induce apoptosis of infiltrating Fas-positive T lymphocytes and subdue any ...
Biagi, E, Brenner, MK, Dotti, G, Pule, M, Rooney, CM, Savoldo, B, Straathof, KC, Vigouroux, S, Yvon, E   +8 more
core  

The convergence of radiation and immunogenic cell death signaling pathways. [PDF]

, 2012
Ionizing radiation (IR) triggers programmed cell death in tumor cells through a variety of highly regulated processes. Radiation-induced tumor cell death has been studied extensively in vitro and is widely attributed to multiple distinct mechanisms ...
Barcellos-Hoff, Mary H, Demaria, Sandra, Formenti, Silvia C, Golden, Encouse B, Pellicciotta, Ilenia   +4 more
core   +2 more sources

Lymphoid‐Tissue‐on‐Chip Recapitulates Human Antibody Responses In Vitro

Advanced Science, EarlyView.
The presented lymphoid‐tissue‐on‐chip system allows culture of primary human tonsil cells at organotypic high density under perfusion for up to 4 weeks, emulates immune response to soluble vaccines and vaccination via peripheral antigen‐presenting cells and represents a useful tool to assess cellular interactions during homeostasis, immune responses ...
Claudia Teufel, Anna‐Sophie Schlemmer, Andrea W. Eiken, Zachary W. Wagoner, Dennis Vöhringer, Lena Christ, Alex Dulovic, Patrick Marsall, Madeleine Fandrich, Eduardo J. S. Brás, Julia Marzi, Friederike Bärhold, Julia Philipp, Sven Becker, Lisa E. Wagar, Peter Loskill   +15 more
wiley   +1 more source

FAS mediates apoptosis, inflammation, and treatment of pathogen infection

Frontiers in Cellular and Infection Microbiology
The FAS cell surface death receptor, a member of the tumor necrosis factor receptor family, activates both apoptotic and non-apoptotic signaling upon interaction with its ligand FASL.
Liying Hu, Liying Hu, Juane Lu, Juane Lu, Hongfei Fan, Changcheng Niu, Changcheng Niu, Yanping Han, Yanping Han, Qinggele Caiyin, Qinggele Caiyin, Qinggele Caiyin, Hao Wu, Jianjun Qiao, Jianjun Qiao, Jianjun Qiao, Jianjun Qiao   +16 more
doaj   +1 more source

Fluoride resistance in fibroblasts is conferred via reduced susceptibility to oxidative stress and apoptosis

FEBS Open Bio, 2020
Chronic fluoride exposure from drinking water may result in endemic fluorosis. To better understand the mechanisms by which some people are resistant to fluorosis, here we investigated the effect of treatment with NaF (sodium fluoride) on production of ...
Jing Ni, Zhe Zhong, Wu Zhang, Bin Liu, Rong Shu, Yiming Li   +5 more
doaj   +1 more source

Protective Effect of Vitamin D against Hepatic Molecular Apoptosis Caused by a High-Fat Diet in Rats

Current Issues in Molecular Biology, 2023
The protective effects of vitamin D (VitD) in different diseases were studied. The liver is of great interest, especially with the presence of VitD receptors. A high-fat diet (HFD) is associated with many diseases, including liver injury.
Huda F. Alshaibi, Sherin Bakhashab, Asma Almuhammadi, Yusuf S. Althobaiti, Mohammed A. Baghdadi, Khadeejah Alsolami   +5 more
doaj   +1 more source