Results 71 to 80 of about 58,729 (255)

FAS mediates apoptosis, inflammation, and treatment of pathogen infection

Frontiers in Cellular and Infection Microbiology
The FAS cell surface death receptor, a member of the tumor necrosis factor receptor family, activates both apoptotic and non-apoptotic signaling upon interaction with its ligand FASL.
Liying Hu, Liying Hu, Juane Lu, Juane Lu, Hongfei Fan, Changcheng Niu, Changcheng Niu, Yanping Han, Yanping Han, Qinggele Caiyin, Qinggele Caiyin, Qinggele Caiyin, Hao Wu, Jianjun Qiao, Jianjun Qiao, Jianjun Qiao, Jianjun Qiao   +16 more
doaj   +1 more source

Fluoride resistance in fibroblasts is conferred via reduced susceptibility to oxidative stress and apoptosis

FEBS Open Bio, 2020
Chronic fluoride exposure from drinking water may result in endemic fluorosis. To better understand the mechanisms by which some people are resistant to fluorosis, here we investigated the effect of treatment with NaF (sodium fluoride) on production of ...
Jing Ni, Zhe Zhong, Wu Zhang, Bin Liu, Rong Shu, Yiming Li   +5 more
doaj   +1 more source

Apoptosis and apoptosis-related proteins (Fas, Fas ligand, bcl-2, p53) in macrophages of human ovarian epithelial tumors.

European journal of gynaecological oncology, 2000
Apoptosis and the apoptosis-related proteins (ARP) (Fas, Fas ligand (FasL), bcl-2 and p53) were analyzed in macrophages of different human ovarian epithelial tumors. Few macrophages were found in ovaries of women without oncologic disorders. In ovarian benign cysts, macrophagic density reached 4.9+/-1.2 per 50,000 microm2, most were present in lymphoid-
H, Ben-Hur, P, Gurevich, A, Ben-Arie, M, Huszar, V, Berman, Y, Tendler, R, Tchanishev, G, Mor, S, Gershon, I, Zusman   +9 more
openaire   +2 more sources

Harnessing ferroptosis from multilayer defense networks to nanoplatforms for specific cancer therapy

BMEMat, EarlyView.
Nanomaterials target metabolically‐regulated ferroptosis for cancer therapy. Iron‐based or alternative nanoplatforms integrate ferroptosis with chemotherapy, immunotherapy, or radiotherapy. They enable stimulus‐responsive therapies (photothermal, photodynamic, sonodynamic) activated by near‐infrared, light, or ultrasound, achieving potent synergistic ...
Xinyue Xu, Xuejian Wang, Wenyan Jiang, Wan Hairul Anuar Kamaruddin, Chunyan Fang, Pengfei Zhang   +5 more
wiley   +1 more source

Spatiotemporal cellular dynamics of the notochord shape intervertebral disc morphogenesis in the mouse embryo through apoptosis and proliferation

Developmental Dynamics, EarlyView.
Abstract Background The notochord is a midline structure essential for vertebrate embryogenesis, contributing to the development of the nervous system, digestive tract, and vertebral column. In particular, notochord signaling is indispensable for proper patterning and coordinated development of alternating vertebrae and intervertebral discs (IVDs ...
Julie Warin, Estelle Balissat, Pauline Colombier, Lily Paillat, Maeva Dutilleul, Anne Camus   +5 more
wiley   +1 more source

The LXR ligand T0901317 induces severe lipogenesis in the db/db diabetic mouse

Journal of Lipid Research, 2003
Liver X receptor (LXR) ligands are currently being evaluated as potential therapeutic agents for the treatment of low HDL. The LXR ligand T0901317 elevates ATP binding cassette transporter A1 (ABCA1) and HDL levels in animal models and induces moderate ...
Jeffrey W. Chisholm, Jenny Hong, Scott A. Mills, Richard M. Lawn   +3 more
doaj   +1 more source

Protective Effect of Vitamin D against Hepatic Molecular Apoptosis Caused by a High-Fat Diet in Rats

Current Issues in Molecular Biology, 2023
The protective effects of vitamin D (VitD) in different diseases were studied. The liver is of great interest, especially with the presence of VitD receptors. A high-fat diet (HFD) is associated with many diseases, including liver injury.
Huda F. Alshaibi, Sherin Bakhashab, Asma Almuhammadi, Yusuf S. Althobaiti, Mohammed A. Baghdadi, Khadeejah Alsolami   +5 more
doaj   +1 more source

Impairment of Fas-ligand–caveolin-1 interaction inhibits Fas-ligand translocation to rafts and Fas-ligand-induced cell death

, 2018
Fas-ligand/CD178 belongs to the TNF family proteins and can induce apoptosis through death receptor Fas/CD95. The important requirement for Fas-ligand-dependent cell death induction is its localization to rafts, cholesterol- and sphingolipid-enriched ...
Xenia A. Glukhova, Vladimir Gogvadze, Igor P. Beletsky, Olga V. Proussakova, Julia A. Trizna   +4 more
core   +1 more source

A FAS-ligand variant associated with autoimmune lymphoproliferative syndrome in cats. [PDF]

, 2017
British shorthair (BSH) kittens in multiple litters died as a result of a severe non-neoplastic lymphoproliferative disease that showed many similarities with human autoimmune lymphoproliferative syndrome (ALPS). Human ALPS is caused by inherited defects
99 Lives, Consortium, Dittmer, Keren E, Garrick, Dorian J, Munday, John S, Gandolfi, Barbara, Malik, Richard, Aberdein, Danielle, Lyons, Leslie A   +7 more
core   +1 more source

Enhancing Optogenetics‐Based Cancer Therapy Via Nanotechnology

Exploration, EarlyView.
Nanotechnology enhances optogenetics‐based cancer therapy through improved delivery systems and non‐invasive optical regulation. It further enables precise and programmable control of optogenetic living therapeutics for localized antitumor responses.
Honggang Shen, Wenzhe Yi, Rongzhang Li, Shuangshuang Hu, Xindi Qian, Dan Yan, Qian Zou, Guanru Wang, Yaping Li   +8 more
wiley   +1 more source