Results 1 to 10 of about 19,135 (133)

Nonpathogenic SIV Infection in Sooty Mangabeys Is Characterized by a Lack of Activation and Expansion of Monocytes. [PDF]

J Med Primatol
ABSTRACT Introduction Natural hosts of simian immunodeficiency virus (SIV), including sooty mangabeys (SMs), maintain high viremia without progressing to AIDS and AIDS‐associated histopathogenesis. The mechanisms underlying this protection and lack of pathogenesis remain incompletely understood, particularly in relation to monocyte/macrophage ...
Soulas C, Nguyen HD, Siddiqui S, Stahr N, Burdo TH, Novembre FJ, Kim WK, Williams KC.   +7 more
europepmc   +2 more sources

Dual IRE1 targets: Determinants of the cell fate? [PDF]

FEBS J
IRE1 is an ER stress sensor that restores protein homeostasis through two signaling activities: XBP1s, which upregulates its target gene expression or RIDD which downregulates its target transcripts. We recently identified Dual IRE1 Targets (DIT) which are modulated by both XBP1s and RIDD activities.
Billat E, Legrand L, Avril T, Lafont E.
europepmc   +2 more sources

3D Cellular Architecture Modulates Tyrosine Kinase Activity, Thereby Switching CD95-Mediated Apoptosis to Survival

Cell Reports, 2019
Summary: The death receptor CD95 is expressed in every cancer cell, thus providing a promising tool to target cancer. Activation of CD95 can, however, lead to apoptosis or proliferation.
Christian Rainer Wirtz, Yvonne Samstag, Emre Balta   +2 more
exaly   +3 more sources

Increased CD95+ or CD160+ double-negative T-cell subsets are associated with incomplete immune reconstitution in ART-treated people living with HIV [PDF]

Frontiers in Immunology
ObjectiveTo investigate the expression patterns of CD95 and CD160 on double-negative T (DN T) cells and their association with incomplete immune reconstitution in people living with HIV.MethodsIn this cross-sectional study, people living with HIV (PLWH ...
Jingli Peng, Yanyan Li, Jiale Xi, Zihao Xia, Ping Luo, Shuo Yang, Lianfeng Lu, Chen Chen, Rentian Cai, Qin Wang, Hongxia Wei   +10 more
doaj   +2 more sources

ZBTB7A regulates CD95-mediated cell growth in colorectal cancer cell lines. [PDF]

PLoS ONE
Zinc Finger and BTB Domain-containing7A (ZBTB7A) is a member of the transcription factor family that regulates the expression of numerous genes involved in cell proliferation and differentiation.
Yanhong Bie, Meiying Bie, Wang Liu, Shufang Tao, Hongyu Xing, Linlin Kuang, Yi Song   +6 more
doaj   +2 more sources

Bacteroides acidifaciens in the gut plays a protective role against CD95-mediated liver injury

Gut Microbes, 2022
The intestinal flora plays an important role in the development of many human and animal diseases. Microbiome association studies revealed the potential regulatory function of intestinal bacteria in many liver diseases, such as autoimmune hepatitis ...
Hesuiyuan Wang, Qing Wang, Chengmao Yang, Mingming Guo, Xiaoyue Cui, Zhe Jing, Yujie Liu, Wanjin Qiao, Hang Qi, Hongyang Zhang, Xu Zhang, Na Zhao, Mengjuan Zhang, Min Chen, Song Zhang, Haijin Xu, Liqing Zhao, Mingqiang Qiao, Zhenzhou Wu   +18 more
doaj   +1 more source

CD95 gene deletion may reduce clonogenic growth and invasiveness of human glioblastoma cells in a CD95 ligand-independent manner

Cell Death Discovery, 2022
CD95 (Fas/APO-1) is a multifunctional cell surface receptor with antithetic roles. First described to mediate cell death, interactions of CD95 with its natural ligand, CD95L, have also been described to induce tumor-promoting signaling leading to ...
Clara Quijano-Rubio, Manuela Silginer, Michael Weller   +2 more
doaj   +1 more source

Involvement of CD95 and ligand in CD4+ T-cell and CD8+ T-cell depletion and hepatic cytolysis in patients with chronic viral hepatitis B

African Journal of Laboratory Medicine, 2021
Background: Chronic viral hepatitis B (HBV) is characterised by progressive hepatocyte destruction and T-cell depletion. The mechanisms of the CD95-CD95 ligand (CD95L) signalling pathway during this chronic disease and the cirrhotic process remains ...
Franklin S. Azebaze Agueguia, Paul Talla, Marie C. Okomo Assoumou, Graeme B. Jacobs, Cedric H. Mbakam, Elise Guiedem, Martha Tongo Mesembe, Emilia Lyonga, George Mondinde Ikomey   +8 more
doaj   +1 more source

Modulation of the CD95-induced apoptosis: the role of CD95 N-glycosylation. [PDF]

PLoS ONE, 2011
Protein modifications of death receptor pathways play a central role in the regulation of apoptosis. It has been demonstrated that O-glycosylation of TRAIL-receptor (R) is essential for sensitivity and resistance towards TRAIL-mediated apoptosis. In this
Olga M Shatnyeva, Andriy V Kubarenko, Claudia E M Weber, Alexander Pappa, Reinhard Schwartz-Albiez, Alexander N R Weber, Peter H Krammer, Inna N Lavrik   +7 more
doaj   +1 more source

Airway epithelial cells and macrophages trigger IL-6-CD95/CD95L axis and mediate initial immunopathology of COVID-19

iScience, 2023
Summary: Airway epithelial cells (AEC) infected with SARS-CoV-2 may drive the dysfunction of macrophages during COVID-19. We hypothesized that the direct interaction of AEC with macrophages mediated by CD95/CD95L or indirect interaction mediated by IL-6 ...
Thais F.C. Fraga-Silva, Ualter G. Cipriano, Marcilio J. Fumagalli, Giseli F. Correa, Carlos A. Fuzo, Douglas dos-Santos, Fabiola L.A.C. Mestriner, Christiane Becari, Andrea Teixeira-Carvalho, Jordana Coelho-dos-Reis, Mayra G. Menegueti, Luiz T.M. Figueiredo, Larissa D. Cunha, Olindo A. Martins-Filho, Marcelo Dias-Baruffi, Maria Auxiliadora-Martins, Rita C. Tostes, Vania L.D. Bonato   +17 more
doaj   +1 more source