Results 31 to 40 of about 24,240 (208)
Molecular mechanisms of CD95 activation [PDF]
, 2012 Die Stimulation des CD95-Todesrezeptors durch seinen natürlichen membranständigen Li-ganden CD95L führt zur kontextabhängigen Aktivierung von sowohl apoptotischen als auch nicht-apoptotischen Signalwegen.
Lang, Isabell
core +2 more sources
MMP7 cleavage of amino-terminal CD95 death receptor switches signaling toward non-apoptotic pathways
Cell Death and Disease, 2022 CD95 is a death receptor that can promote oncogenesis through molecular mechanisms that are not fully elucidated. Although the mature CD95 membrane receptor is considered to start with the arginine at position 17 after elimination of the signal peptide ...
Shoji F. Kenji +12 more
doaj +1 more source
Analysis of novel meningococcal vaccine formulations
Human Vaccines & Immunotherapeutics, 2017 The protective effect of meningococcal vaccines targeting disease causing serogroups exemplified by the introduction of MenAfriVac™ in Africa, is well established and documented in large population-based studies.
Susu M. Zughaier
doaj +1 more source
Pro- and anti-apoptotic CD95 signaling in T cells
Cell Communication and Signaling, 2011 The TNF receptor superfamily member CD95 (Fas, APO-1, TNFRSF6) is known as the prototypic death receptor in and outside the immune system. In fact, many mechanisms involved in apoptotic signaling cascades were solved by addressing consequences and ...
Janssen Ottmar, Paulsen Maren
doaj +1 more source
Folia Medica Indonesiana, 2017 Urothelial Cell Carcinoma (UCC), also called transitional cell carcinoma of the bladder, is the most common malignancy in urinary tract. The prognosis of this disease is highly dependent on the histological grading at diagnosis.
Heryanto Heryanto +2 more
doaj +1 more source
Role of the CD95/CD95 Ligand System in Glucocorticoid-Induced Monocyte Apoptosis [PDF]
The Journal of Immunology, 2001 Abstract Glucocorticoids (GC) act as potent anti-inflammatory and immunosuppressive agents on a variety of immune cells. However, the exact mechanisms of their action are still unknown. Recently, we demonstrated that GC induce apoptosis in human peripheral blood monocytes.
M, Schmidt +6 more
openaire +2 more sources
Инфекция и иммунитет, 2016 Acute infectious mononucleosis is a widespread viral disease, which most often manifests in childhood. The development of acute infectious mononucleosis is accompanied by the change of the CD4+/CD8+ T-lymphocytes ratio and the increase of the virus ...
E. N. Filatova +5 more
doaj +1 more source
, 2002 Immunosenescence is believed to contribute to increase susceptibility to infectious diseases and cancer in the elderly, and is caused mainly by changes in the T cell compartment.
Barcia, Rita N. +2 more
core +1 more source
CD95 is part of a let-7/p53/miR-34 regulatory network. [PDF]
PLoS ONE, 2012 The death receptor CD95 (APO-1/Fas) mediates apoptosis induction upon ligation by its cognate ligand CD95L. Two types of CD95 signaling pathways have been identified, which are characterized by the absence (Type I) or presence (Type II) of mitochondrial ...
Annika Hau, Paolo Ceppi, Marcus E Peter
doaj +1 more source
NF-κB signaling and crosstalk during carcinogenesis
4 open, 2019 Transcription factors (TFs) are proteins that control the transcription of genetic information from DNA to mRNA by binding to specific DNA sequences either on their own or with other proteins as a complex.
Brücher Björn L.D.M. +2 more
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