Results 51 to 60 of about 24,240 (208)

Immunogenetic characteristics of LADA

Сахарный диабет, 2011
Latent autoimmune diabetes of adults (LADA) is a variant of autoimmune diabetes mellitus. Its clinical feature not typical for classical DM1 despitethe presence of positive autoantibodies is characterized by the low rate of autoimmune destruction that ...
Tatiana Vasil'evna Nikonova, Pavel Vasil'evich Apanovich, Elena Vladimirovna Pekareva, Vera Anatol'evna Gorelysheva, Svetlana Mikhailovna Stepanova, Yulia Vladimirovna Tishina, Sergey Alexandrovich Prokof'ev, Alexander Vasil'evich Karpukhin   +7 more
doaj   +1 more source

Dnmt3a Mutations Limit Normal and Autoreactive CD4+ T Follicular Helper Responses and Attenuate T Cell–Driven Joint Inflammation

Arthritis &Rheumatology, EarlyView.
Objective Somatic DNMT3A mutations are the most common drivers of clonal hematopoiesis in patients with rheumatoid arthritis (RA) and have been associated with seropositive disease and increased markers of inflammation. These mutations are predominantly hypomorphic or dominant‐negative, reducing DNMT3A function.
Yunbing Shen, Sanjaykumar Boddul, Zhaojun Li, Zsolt Kasza, Marlene Schülein, Bruno Raposo, Karine Chemin, Per‐Johan Jakobsson, Alexander Espinosa, Lars Klareskog, Fredrik Wermeling   +10 more
wiley   +1 more source

The Crosstalk of Apoptotic and Non-Apoptotic Signaling in CD95 System

Cells
The mechanisms of CD95 (Fas/APO-1)-mediated extrinsic apoptotic pathway in cancer cells have been extensively studied. The majority of human cells express CD95, but not all these cells can induce extrinsic apoptosis.
Kamil Seyrek, Johannes Espe, Elisabeth Reiss, Inna N. Lavrik   +3 more
doaj   +1 more source

APOPTOSIS OF BLOOD LYMPHOCYTES IN THE PATIENTS WITH AUTOIMMUNE THYROID DISORDERS

Медицинская иммунология, 2014
. This article presents results of apoptosis detection among blood lymphocytes from the patients with autoimmune thyroid disorders, i.e., autoimmune thyroiditis (AIT) at euthyroid and hypothyroid stages, and in diffuse toxic goiter (DTG).
O. I. Urazova, E. B. Kravets, V. V. Novitsky, A. V. Rogaleva, T. E. Budkina, O. A. Sinyukova, Yu. V. Nedossekova, V. N. Kuznetsova   +7 more
doaj   +1 more source

Deep Immunophenotyping Reveals Distinct Immune Signatures in Axial Spondyloarthritis and Psoriatic Arthritis

Arthritis &Rheumatology, EarlyView.
Objective Axial spondyloarthritis (axSpA) and psoriatic arthritis (PsA) are overlapping yet distinct conditions within the SpA spectrum. As divergent immunophenotypes may influence disease course and therapeutic response, we compared immune cell subsets, cytokine profiles, and inflammatory mediators.
Natalie Frede, Nils Craig‐Müller, Silke Kohrt, Marei‐Theresa Bott, Ulrich Salzer, Ana Cecilia Venhoff, Jens Thiel, Julia Frede, Reinhard E. Voll, Marta Rizzi, Raquel Lorenzetti, Nils Venhoff   +11 more
wiley   +1 more source

CD95 promotes tumour growth [PDF]

Nature, 2010
CD95 (also called Fas and APO-1) is a prototypical death receptor that regulates tissue homeostasis mainly in the immune system through the induction of apoptosis. During cancer progression CD95 is frequently downregulated or cells are rendered apoptosis resistant, raising the possibility that loss of CD95 is part of a mechanism for tumour evasion ...
Lina, Chen, Sun-Mi, Park, Alexei V, Tumanov, Annika, Hau, Kenjiro, Sawada, Christine, Feig, Jerrold R, Turner, Yang-Xin, Fu, Iris L, Romero, Ernst, Lengyel, Marcus E, Peter   +10 more
openaire   +2 more sources

Caspase 8 activation independent of Fas (CD95/APO-1) signaling may mediate killing of B-chronic lymphocytic leukemia cells by cytotoxic drugs or gamma radiation. [PDF]

, 2001
Ligation of the cell-surface Fas molecule by its ligand (Fas-L) or agonistic anti-Fas monoclonal antibodies results in the cleavage and activation of the cysteine protease procaspase 8 followed by the activation of procaspase 3 and by apoptosis.
Jones, DT, Ganeshaguru, K, Mehta, AB, Prentice, HG, Virchis, AE, Lowdell, MW, Wickremasinghe, RG, Hoffbrand, AV, Folarin, NI   +8 more
core  

Total T Cell Density and Expression of T Memory Stem Cell Markers are Associated with Better Prognosis in Colon Cancer

International Journal of General Medicine, 2023
Junli Ding,1,* Hao Wang,1,* Rui Hou,1,* Yuxin Shi,1 Honghong Fan,1 Yuting Li,1 Jie Mei,1 Qinglin Zhang,2 Tingyan Ruan,1 Junying Xu1 1Department of Oncology, The Affiliated Wuxi People’s Hospital of Nanjing Medical University, Wuxi, 214023 ...
Ding J, Wang H, Hou R, Shi Y, Fan H, Li Y, Mei J, Zhang Q, Ruan T, Xu J   +9 more
doaj  

Persistent Interleukin‐18 Fuels Expansion of CD38+HLA‐DR+CD8+ T Cells in Still Disease and Macrophage Activation Syndrome

Arthritis &Rheumatology, EarlyView.
Objective Still disease (SD) is an autoinflammatory disorder characterized by remarkably high interleukin‐18 (IL‐18) levels. Increasing evidence suggests that adaptive immunity also contributes to its pathogenesis, particularly in refractory courses. Macrophage activation syndrome (MAS), one of SD's most severe complications, is associated with further
Greta Rogani, Remco G. A. Erkens, Alejandra Bodelón, Tim R. Mocking, Marein T. M. Putmans, Freya M. C. H. Huijsmans, Lyanne J. P. M. Sijbers, Aafke M. De Ligt, Maurice J. H. Van Haaren, Rianne C. Scholman, Noël M. M. Dautzenberg, Joyce I. Meesters‐Ensing, Martina Rossano, Laura Porretti, Stefan Nierkens, Francesca S. Minoia, Sebastiaan J. Vastert, Jorg van Loosdregt   +17 more
wiley   +1 more source

CD95/CD95L interactions and their role in autoimmunity [PDF]

, 2000
CD95 (Fas/Apo-1) is a broadly expressed death receptor involved in a variety of physiological and pathological apoptotic processes. Since its discovery, defects in CD95/CD95L system have been proposed as major pathogenic factors responsible for impaired ...
De Maria, R.
core   +1 more source