CNS Macrophages Control Neurovascular Development via CD95L [PDF]
Cell Reports, 2017 The development of neurons and vessels shares striking anatomical and molecular features, and it is presumably orchestrated by an overlapping repertoire of extracellular signals.
Carmen Ruiz De Almodovar +2 more
exaly +8 more sources
The dual role of the CD95 and CD95L signaling pathway in glioblastoma [PDF]
Frontiers in Immunology, 2022 Binding of CD95, a cell surface death receptor, to its homologous ligand CD95L, transduces a cascade of downstream signals leading to apoptosis crucial for immune homeostasis and immune surveillance.
Yanrui Zhang +7 more
doaj +4 more sources
CD95/Fas ligand mRNA is toxic to cells through more than one mechanism [PDF]
Molecular Biomedicine, 2023 CD95/Fas ligand (CD95L) induces apoptosis through protein binding to the CD95 receptor. However, CD95L mRNA also induces toxicity in the absence of CD95 through induction of DISE (Death Induced by Survival Gene Elimination), a form of cell death mediated
Ashley Haluck-Kangas +3 more
doaj +2 more sources
Role of metalloproteases in the CD95 signaling pathways [PDF]
Frontiers in Immunology, 2022 CD95L (also known as FasL or CD178) is a member of the tumor necrosis family (TNF) superfamily. Although this transmembrane ligand has been mainly considered as a potent apoptotic inducer in CD95 (Fas)-expressing cells, more recent studies pointed out ...
Laurent Devel +5 more
doaj +2 more sources
Airway epithelial cells and macrophages trigger IL-6-CD95/CD95L axis and mediate initial immunopathology of COVID-19 [PDF]
iScience, 2023 Summary: Airway epithelial cells (AEC) infected with SARS-CoV-2 may drive the dysfunction of macrophages during COVID-19. We hypothesized that the direct interaction of AEC with macrophages mediated by CD95/CD95L or indirect interaction mediated by IL-6 ...
Thais F.C. Fraga-Silva +17 more
doaj +2 more sources
High yield purification of an isoleucine zipper-modified CD95 ligand for efficient cell apoptosis initiation and with biotin or DNA-oligomer binding domain to probe ligand functionalization effects [PDF]
BMC BiotechnologyBackground Cluster of differentiation 95 (CD95/Fas/Apo1) as part of the Tumor-necrosis factor (TNF) receptor family is a prototypic trigger of the ‘extrinsic’ apoptotic pathway and its activation by the trimeric ligand CD95L is of high interest. However,
Xiaoyue Shang +7 more
doaj +2 more sources
Dual IRE1 targets: Determinants of the cell fate? [PDF]
FEBS JIRE1 is an ER stress sensor that restores protein homeostasis through two signaling activities: XBP1s, which upregulates its target gene expression or RIDD which downregulates its target transcripts. We recently identified Dual IRE1 Targets (DIT) which are modulated by both XBP1s and RIDD activities.
Billat E, Legrand L, Avril T, Lafont E.
europepmc +2 more sources
CD95 gene deletion may reduce clonogenic growth and invasiveness of human glioblastoma cells in a CD95 ligand-independent manner [PDF]
Cell Death Discovery, 2022 CD95 (Fas/APO-1) is a multifunctional cell surface receptor with antithetic roles. First described to mediate cell death, interactions of CD95 with its natural ligand, CD95L, have also been described to induce tumor-promoting signaling leading to ...
Clara Quijano-Rubio +2 more
doaj +2 more sources
Correction: The Naturally Processed CD95L Elicits a c-Yes/Calcium/PI3K-Driven Cell Migration Pathway. [PDF]
PLoS Biology, 2023 [This corrects the article DOI: 10.1371/journal.pbio.1001090.].
Sébastien Tauzin +13 more
doaj +3 more sources
Soluble CD95L triggers Caspase-10-driven reactive oxygen species production in neutrophils and aggravates anti-neutrophil cytoplasmic antibody-vasculitis [PDF]
Nature CommunicationsAnti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is a severe autoimmune disease that lacks effective targeted therapies. T cell and neutrophil activation are associated with tissue lesions in ANCA-associated vasculitis responsible ...
Andréa Boizard-Moracchini +27 more
doaj +2 more sources