Results 21 to 30 of about 3,939 (188)
IRE1 RNase controls CD95-mediated cell death [PDF]
EMBO ReportsSignalling by the Unfolded Protein Response (UPR) or by the Death Receptors (DR) are frequently activated towards pro-tumoral outputs in cancer. Herein, we demonstrate that the UPR sensor IRE1 controls the expression of the DR CD95/Fas, and its cell ...
Diana Pelizzari-Raymundo +11 more
doaj +2 more sources
Oligomerised RIPK1 is the main core component of the CD95 necrosome [PDF]
The EMBO JournalThe necrosome is the key macromolecular signaling platform initiating necroptosis, i.e., a RIPK1/RIPK3-dependent program of cell death with an important role in the control of inflammation in multicellular organisms.
Nikita V Ivanisenko +8 more
doaj +2 more sources
Cell Apoptosis and Glucocorticoid‐Induced Osteonecrosis
Med ResearchGlucocorticoids (GCs) are steroid hormones commonly used to treat inflammation, autoimmune diseases, and malignant tumors. By inhibiting bone formation and promoting osteoclast apoptosis, GCs significantly accelerate the onset of femoral head ...
Xiumei Tang +7 more
doaj +2 more sources
Method to Measure Sphingomyelin Synthase Activity Changes in Response to CD95L
, 2017 Sphingomyelin synthases 1 and 2 convert the anti-oncometabolite ceramide to sphingomyelin, the most abundant sphingolipid in plasma membrane. CD95L-induced ceramide increase is associated with the caspase-dependent inhibition of sphingomyelin synthesis, which enhances the mitochondrial route to apoptosis.
Bilal, Fatima +6 more
openaire +4 more sources
The CD95/CD95L signaling pathway: A role in carcinogenesis [PDF]
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, 2014 Apoptosis is a fundamental process that contributes to tissue homeostasis, immune responses, and development. The receptor CD95, also called Fas, is a member of the tumor necrosis factor receptor (TNF-R) superfamily. Its cognate ligand, CD95L, is implicated in immune homeostasis and immune surveillance, and various lineages of malignant cells exhibit ...
Fouqué, Amélie +2 more
openaire +6 more sources
Indonesian Journal of Cancer, 2022 Background: Programmed Death Ligand (PD-L1) and Cluster of Differentiation 95 (CD95L) are influenced by oncogenes and function in the anti-apoptosis process which is thought to play a role in chemotherapy resistance.
Hasrayati Agustina +2 more
doaj +1 more source
Blockade of CD95/CD95L death signaling enhances CAR T cell persistence and antitumor efficacy [PDF]
, 2021 Despite the encouraging outcome of anti-CD19 chimeric antigen receptor T (CAR T) cell therapy in patients with B cell malignancies, CAR T cell persistence remains a major clinical challenge.
He, Bailin
core +1 more source
African Journal of Laboratory Medicine, 2021 Background: Chronic viral hepatitis B (HBV) is characterised by progressive hepatocyte destruction and T-cell depletion. The mechanisms of the CD95-CD95 ligand (CD95L) signalling pathway during this chronic disease and the cirrhotic process remains ...
Franklin S. Azebaze Agueguia +8 more
doaj +1 more source
The influence of CD95L expression on tumor rejection in mice [PDF]
European Journal of Immunology, 2003 AbstractMany tumors express the death ligand CD95L (CD178, APO‐1L, FasL) and can kill activated T cells in vitro. This may enable the tumor cells to suppress anti‐tumor immune responses, a phenomenon called "tumor counterattack". Preliminary evidence of tumor counterattack in human tumors exists. However, CD95L‐expressing tumors are rapidly rejected in
Frederik H, Igney +2 more
openaire +2 more sources
BAPTA-AM abrogates the cl-CD95L-mediated Ca2+ response.
, 2023 (A) H9 T-cells were loaded with 1 mM of the calcium probe Fura-2AM for 30 min at RT. Cells were pre-incubated or not (DMSO) with BAPTA-AM (5 mM) and then stimulated with 100 ng/ml of cl-CD95L. Values were recorded every 10 s.
Eric Selva (216754) +13 more
core +1 more source