Results 71 to 80 of about 24,240 (208)

Fas/CD95 Ligation Induces Proliferation of Primary Fetal Astrocytes Through a Mechanism Involving Caspase 8-Mediated ERK Activation

Cellular Physiology and Biochemistry, 2013
Background: Fas/CD95 is the best-studied member of the death receptor (DR) superfamily in the central nervous system where it can trigger cellular responses other than apoptosis, including the promotion of neurogenesis and neuritogenesis, stimulation of ...
Olga Barca, Marcos Seoane, Rosa Mª Señarís, Víctor M. Arce   +3 more
doaj   +1 more source

Investigating CD8 T Cell Exhaustion in Chronic LCMV Infection by Flow Cytometry

Current Protocols, Volume 6, Issue 10, October 2026.
Abstract CD8 T cells and the process of T cell exhaustion are central topics in both basic immunology and translational research, including clinical applications. Here, we provide a comprehensive, step‐by‐step guide to investigate CD8 T cells in murine in vivo lymphocytic choriomeningitis virus (LCMV) infection models.
Dominique Stark, Marie‐Elen Tuchel, Gautier Stehli, Alessandro Genovese, Isaak Quast, Annette Oxenius   +5 more
wiley   +1 more source

Enrichment and Proteomic Profiling of Stromal‐Associated Extracellular Vesicle Subpopulations From Arthritic Synovial Fluid by Size‐Exclusion Chromatography Coupled to CD90‐Directed Immunocapture

Journal of Extracellular Vesicles, Volume 15, Issue 10, October 2026.
Synovial fluid contains heterogeneous EV populations reflecting stromal and immune‐associated cellular inputs from the arthritic joint. SEC‐UF enrichment coupled to CD90‐targeted immunocapture enables recovery of stromal‐associated EV subpopulation from complex patient synovial fluid, while focused LC‐MS/MS and cell‐of‐origin analysis enable molecular ...
Stefanie Kurth, Edveena Hanser, Simone Häner‐Massimi, Stavros Giaglis, Florian Geier, Dominik Burri, Katarzyna Buczak, Ute Heider, Stefan Wild, Yves P. Acklin, Christian Egloff, André N. Tiaden, Diego Kyburz   +12 more
wiley   +1 more source

Engineering Antibodies into Targeted Chimeras: From Recognition Modules to Programmable Degraders

Advanced Science, Volume 13, Issue 50, 7 September 2026.
Antibody can be engineered into diverse lysosome‐targeting chimeras that convert target recognition into active degradation. By coupling antibody binding with recruited receptors, encoded domains, conjugated ligands, or nanoparticle scaffolds, these antibody‐associated targeted chimeras (AbTACs) platforms direct extracellular and membrane proteins ...
Kaige Chen, Quanyin Hu
wiley   +1 more source

4‐2 VHL‐Recruiting PROTAC Inhibits the Growth and Migration of Triple Negative Breast Cancer Cells by Triggering Pyroptosis Through Fas‐Mediated IL‐17 Signaling

Drug Development Research, Volume 87, Issue 6, September 2026.
ABSTRACT SND1 is an oncoprotein found to be overexpressed in breast cancer, especially in triple‐negative breast cancer(TNBC). In our previous study, a novel SND1‐interacting peptide 4‐2 was identified, exhibiting cytotoxicity to TNBC cells by inducing SND1 degradation.
Qiqi Wang, Qiufeng Huang, Huiping Ou, Tingting Huang, Yunjiao He, Peng Li   +5 more
wiley   +1 more source

The CD95 signaling pathway

Communicative & Integrative Biology, 2012
Our recent findings indicate that cells exposed to transmembrane (m-CD95L) or metalloprotease-cleaved CD95L (cl-CD95L) undergo a localized Ca(2+)entry that not only inhibits the initial steps of the CD95-mediated apoptotic signal but also promotes cell motility. Based on recent findings published on the non-apoptotic signals induced by CD95, we discuss
Penna, Aubin, Khadra, Nadine, Tauzin, Sébastien, Vacher, Pierre, Legembre, Patrick   +4 more
openaire   +3 more sources

Contribution of CD95 to the activation of innate immune response [PDF]

, 2016
Myeloid cell recruitment plays a pivotal role in innate immune response. It comprises a cascade of sequential cellular processes including slow rolling, activation and firm adhesion, and transendothelial cell migration.
Gao, Liang
core   +1 more source

Cinnamaldehyde From Cinnamon as a Food‐Derived Bioactive: Phytochemistry, Anticancer Mechanisms, Bioavailability, Nanoformulation and Safety

Food Frontiers, Volume 7, Issue 5, September 2026.
Cinnamaldehyde derived from Cinnamomum species exerts multitarget anticancer effects by promoting oxidative stress, mitochondrial dysfunction, apoptosis, cell‐cycle arrest, autophagy, and epigenetic changes, and by suppressing mitogen‐activated protein kinase (MAPK), phosphoinositide 3‐kinase/protein kinase B/mechanistic target of rapamycin (PI3K/Akt ...
Gervason Moriasi, Sally Kamau, Gulnaz Seitimova, Shynar Zhumagaliyeva, Javad Sharifi‐Rad, William N. Setzer, Daniela Calina   +6 more
wiley   +1 more source

CD95 Signaling via Ceramide-rich Membrane Rafts

, 2001
Clustering seems to be employed by many receptors for transmembrane signaling. Here, we show that acid sphingomyelinase (ASM)-released ceramide is essential for clustering of CD95.
Konrad Sandhoff, Jeckle, A., Grassme, H., Heike Grassme, Riehle, A., Schwarz, H., Heinz Schwarz, Berger, J., Richard Kolesnick, Andreas Jekle, Jürgen Berger, Sandhoff, K., Gulbins, E., Andrea Riehle, Kolesnick, R., Erich Gulbins   +15 more
core   +1 more source

Burmannic Acid With Normal Cell Safety Exhibits ROS‐Mediated X‐Ray‐Sensitizing Effects on Oral Cancer Cells

ChemistrySelect, Volume 11, Issue 36, 22 September 2026.
Burmannic acid (BURA) boosts radiosensitivity in oral cancer: combined with x‐rays, it suppresses tumor growth while sparing normal cells by increasing reactive oxygen species (ROS, MitoSOX), causing G2/M arrest, sub‐G1 accumulation, mitochondrial dysfunction, DNA damage, and apoptosis; these effects are reversed by N‐acetylcysteine. Therefore, BURA is
Kun‐Han Yang, Chung‐Yi Chen, Ching‐Yu Yen, Hsin‐I Lu, Jen‐Yang Tang, Tsu‐Ming Chien, Fang‐Rong Chang, Jiiang‐Huei Jeng, Ming‐Yii Huang, Hsueh‐Wei Chang   +9 more
wiley   +1 more source