Results 91 to 100 of about 24,240 (208)

CD95/Fas and metastatic disease: What does not kill you makes you stronger [PDF]

, 2019
International audienceCD95 (also known as Fas) is the prototype of death receptors; however, evidence suggests that this receptor mainly implements non-apoptotic signaling pathways such as NF-κB, MAPK, and PI3K that are involved in cell migration ...
Guégan, Jean Philippe, Vacher, Pierre, Quignard, Jean-François, Ginestier, Christophe, Ducret, Thomas, Legembre, Patrick, Charafe-Jauffret, Emmanuelle   +6 more
core   +1 more source

Regulation of CD95-induced NF-[Kappa]B activation

, 2019
It is well understood that the death receptor CD95 induces apoptotic cell death but also pro-survival signaling. Defective regulation of CD95 signaling is connected to a number of diseases.
Buchbinder, Jörn Holger
core   +1 more source

Quantification of High-Molecular Weight Protein Platforms by AQUA Mass Spectrometry as Exemplified for the CD95 Death-Inducing Signaling Complex (DISC)

Cells, 2013
Contemporary quantitative mass spectrometry provides fascinating opportunities in defining the stoichiometry of high-molecular weight complexes or multiprotein platforms.
Inna Lavrik, Uwe Warnken, Kolja Schleich, Martina Schnölzer   +3 more
doaj   +1 more source

Structural and functional investigation of the cytoplasmic domain of the Fas death receptor [PDF]

, 2015
Activation of the transmembrane death receptor Fas (CD95/APO-1) by a membrane bound ligand (FasL/CD95L) activates the extrinsic pathway of apoptosis. Intracellular Fas death domains (DDs) are induced to oligomerise enabling binding to the adaptor protein
Wildsmith, GC
core  

A chimeric CD95-gp130 construct confirms the presence of a PLAD in the CD95 ectodomain. A.

, 2013
The intracellular domain of gp130 is pre-associated with JAK kinase. If the ectodomains of CD95 are pre-associated, the intracellular regions of a CD95-gp130 construct will be brought in close proximity, inducing the trans-activation of JAKs and the ...
Valérie Edmond (305962), Jean-Luc Taupin (290093), Sophie Daburon (216759), Jean-François Moreau (11510), Benoist Ghali (305963), Patrick Legembre (216769), Aubin Penna (305964)   +6 more
core   +1 more source

Lipid signaling in CD95-mediated apoptosis [PDF]

, 1999
Ceramides play an important role mediating different cell responses such as proliferation, differentiation, growth arrest and apoptosis. They are released upon sphingomyelin hydrolysis which occurs after triggering of a number of cell surface receptors ...
Roberto Testi, Malisan, Florence, Florence Malisan, Testi, Roberto   +3 more
core   +1 more source

Systemic biomarkers of apoptosis and endothelial activation in the pathogenesis of rubeosis iridis and iridocorneal angle neovascularisation in secondary neovascular glaucoma

Медична наука України
Aim. To assess systemic levels of CD95 (Fas) and ICAM-1 (CD54) in patients with secondary neovascular glaucoma (NVG), to determine the relationship with the severity of iris rubeosis and the iridocorneal angle, and to evaluate the role of endothelial ...
Olga Guzun, Liudmyla Velychko
doaj   +1 more source

A noncomitogenic CD2R monoclonal antibody induces apoptosis of activated T cells by a CD95/CD95-L-dependent pathway.

, 1998
Clonal expansion of activated T and B cells is controlled by homeostatic mechanisms resulting in apoptosis of a large proportion of activated cells, mostly through interaction between CD95 (Fas or Apo-1) receptor and its ligand CD95-L.
Bonnefoy-Bérard, N, Waldmann, H, Bismuth, G, Robinet, E, Flacher, M, Fournel, S, Revillard, JP, Assossou, O, Waldmann, Herman   +8 more
core  

Identification, characterisation and regulation by CD40 activation of novel CD95 splice variants in CD95-apoptosis-resistant, human, B-cell non-Hodgkin's lymphoma.

, 2009
International audienceCD95 gene and splicing aberrations have been detected in B-cell non-Hodgkin lymphoma (B-NHL) where they are thought to contribute to CD95 apoptosis resistance. To further investigate this, we have performed extensive CD95 transcript
Chauvet, Martine, Marie-Anne Pasquier, Gressin, Remy, Florin, Anne, Pasquier, Marie-Anne, Lajmanovich, Alicia, Ribeyron, Juliana Bruder, Juliana Bruder Ribeyron, Plumas, Joël, Dominique Leroux, Leroux, Dominique, Mary B. Callanan, Remy Gressin, Duley, Samuel, Alexandra Fournier, Anne Florin, Bonnefoix, Thierry, Alicia Lajmanovich, Samuel Duley, Fournier, Alexandra, Thierry Bonnefoix, Joel Plumas, Callanan, Mary, B., Martine Chauvet   +23 more
core   +1 more source

Dynamics within the CD95 death‐inducing signaling complex decide life and death of cells

Molecular Systems Biology, 2010
This study explores the dilemma in cellular signaling that triggering of CD95 (Fas/APO‐1) in some situations results in cell death and in others leads to the activation of NF‐κB.
Leo Neumann, Carina Pforr, Joel Beaudouin, Alexander Pappa, Nicolai Fricker, Peter H Krammer, Inna N Lavrik, Roland Eils   +7 more
doaj   +1 more source