Results 101 to 110 of about 24,240 (208)

Induction of CD95 upregulation does not render chronic lymphocytic leukemia B-cells susceptible to CD95-mediated apoptosis

, 2005
B-cell chronic lymphocytic leukemia (B-CLL) is characterized by a progressive accumulation of long-lived and well-differentiated clonal Blymphocytes in peripheral blood, lymphoid tissue and bone marrow.
LUCIVERO, Giacomo, ROMANO, Ciro Pasquale, GIUNTA, Riccardo, SELLITTO A, ROTOLI B, CHIURAZZI F, FANIS UD, GUASTAFIERRO, Salvatore, TIRELLI, Armando   +8 more
core   +1 more source

Arachidonic acid metabolism in TNF, CD178 (CD95 ligand) and ceramide-mediated cytotoxicity

Archives of Medical Science, 2007
Introduction: Arachidonic acid release has been reported to play a significant role in TNF-induced cytotoxicity. However, the role of this signalling cascade in CD178-(CD95 ligand)mediated cytotoxicity remains unclear.
Monika Ołdak, Jarosław Joźwiak, Radosław Maksym, Jacek Malejczyk   +3 more
doaj  

Identification and relevance of the CD95-binding domain in the N-terminal region of ezrin

, 2004
The CD95 (Fas/APO-1) linkage to the actin cytoskeleton through ezrin is an essential requirement for susceptibility to the CD95-mediated apoptosis in CD4+ T cells. We have previously shown that moesin was not involved in the binding to CD95.
LOZUPONE F, LUCIANI F, STASSI, Giorgio, FEDERICI C, MATARRESE P, MARGUTTI P, FAIS S., LUGINI L, IESSI E, MALORNI W   +9 more
core   +1 more source

The multilevel regulation of CD95 signaling outcome

, 2012
CD95, also called Fas or APO-1, was the first death receptor (DR) identified and characterized. Studies on CD95 receptor signaling revealed the versatile principles of cell fate regulation via DR.
Sidorenko, S.P., Shlapatska, L.M., Yurchenko, M.   +2 more
core   +1 more source

Dengue Viral Infection Induces Alteration of CD95 Expression in B Cell Subsets with Potential Involvement of Dengue Viral Non-Structural Protein 1

Viruses
Little is known about the regulation of B cell subpopulations in association with programmed cell death during dengue virus (DENV) infection. Therefore, blood samples from dengue-infected patients and healthy donors were obtained for B cell subset ...
Siyu Wang, Premrutai Thitilertdecha, Ladawan Khowawisetsut, Theeraporn Maneesawat, Ampaiwan Chuansumrit, Kulkanya Chokephaibulkit, Kovit Pattanapanyasat, Nattawat Onlamoon   +7 more
doaj   +1 more source

Conversion of CD95 (Fas) Type II into Type I signaling by sub-lethal doses of cycloheximide

, 2008
CD95 (Fas/Apo-1)-mediated apoptosis was shown to occur through two distinct pathways. One involves a direct activation of caspase-3 by large amounts of caspase-8 generated at the DISC (Type I cells).
Amarante-Mendes, G P, Amarante-Mendes, Gustavo P., Brumatti, Gabriela, BUENO-DA-SILVA, A. E. B., Bueno-da-Silva, A E B, BRUMATTI, G., Castro, Fabiola A., Brunner, Thomas, Bueno-da-Silva, Ana Elisa Barreiros, Jacysyn, J F, BRUNNER, T., Jacysyn, Jacqueline F., Yon, M, Brumatti, G, YON, M., Brunner, T, AMARANTE-MENDES, G. P., Yon, Monica, Castro, Felipe A., Castro, F A, JACYSYN, J. F., CASTRO, F. A.   +21 more
core   +1 more source

Detection of S-Acylated CD95 by Acyl-Biotin Exchange

, 2017
International audienceS-acylation is the covalent addition of a fatty acid, most generally palmitate onto cysteine residues of proteins through a labile thioester linkage. The death receptor CD95 is Spalmitoylated and this post-translational modification
Aurelie Rossin, Anne-Odile Hueber, Rossin, Aurélie, Hueber, Anne-Odile   +3 more
core   +1 more source

The influence of human endotoxemia on CD95-induced apoptosis.

, 1998
BACKGROUND: The responses of monocyte and neutrophil tumor necrosis factor receptor type 1 (TNFR-1) and TNFR-2 during systemic inflammation have been described previously. Several other members of the TNFR superfamily also appear to have regulatory roles
Kumar, A, Katz, J A, Calvano, S E, Lowry, S F, Lin, E, Shahin, I, Randhawa, S, Coyle, S M   +7 more
core   +1 more source

CD95/Fas stoichiometry in future precision medicine

CD95, also known as Fas, belongs to the tumor necrosis factor (TNF) receptor superfamily. The main biological function of this receptor is to orchestrate and control the immune response since mutations in CD95 or deregulation of its downstream signaling ...
Sica, Mauricio Pablo, Legembre, Patrick, Roussel, Murielle   +2 more
core   +1 more source

Cervical Cancer Cells Use the CD95 and IL-2 Pathways to Promote Their Proliferation and Survival

Biomolecules
Cervical cancer is a global health problem; therapies focused on eliminating tumour cells and strengthening different immunotherapies are in development.
Adriana Gutiérrez-Hoya, Ivan Ortiz-Garrido, Itzel Salazar-Valencia, Christopher Romero-Hernández, Arturo Valle-Mendiola, Benny Weiss-Steider, Isabel Soto-Cruz   +6 more
doaj   +1 more source