Results 11 to 20 of about 24,240 (208)

Death Induced by CD95 or CD95 Ligand Elimination [PDF]

Cell Reports, 2014
CD95 (Fas/APO-1), when bound by its cognate ligand CD95L, induces cells to die by apoptosis. We now show that elimination of CD95 or CD95L results in a form of cell death that is independent of caspase-8, RIPK1/MLKL, and p53, is not inhibited by Bcl-xL ...
Abbas Hadji, Paolo Ceppi, Andrea E. Murmann, Sonia Brockway, Abhinandan Pattanayak, Bhavneet Bhinder, Annika Hau, Shirley De Chant, Vamsi Parimi, Piotre Kolesza, JoAnne Richards, Navdeep Chandel, Hakim Djaballah, Marcus E. Peter   +13 more
doaj   +4 more sources

The Role of CD95 Glycosylation in CD95 Signaling [PDF]

, 2010
The CD95 (APO-1/Fas)-mediated apoptotic pathway is one of the well-studied death receptor pathways. CD95 is a highly glycosylated type I transmembrane protein and has a molecular mass of 37.5 kDa. The N-terminal domain of CD95 contains two putative N-linked glycosylation sites at N118 and N136 and posttranslational glycosylation leads to an increase of
Shatnyeva, Olga M.
openaire   +3 more sources

The CD95 Receptor: Apoptosis Revisited [PDF]

Cell, 2007
CD95 is the quintessential death receptor and, when it is bound by ligand, cells undergo apoptosis. Recent evidence suggests, however, that CD95 mediates not only apoptosis but also diverse nonapoptotic functions depending on the tissue and the conditions.
Peter, Marcus E., Budd, Ralph C., Desbarats, Julie, Hedrick, Stephen M., Hueber, Anne-Odile, Newell, M. Karen, Owen, Laurie B., Pope, Richard M., Tschopp, Juerg, Wajant, Harald, Wallach, David, Wiltrout, Robert H., Zörnig, Martin, Lynch, David H.   +13 more
core   +5 more sources

CD95/Fas protects triple negative breast cancer from anti-tumor activity of NK cells

iScience, 2021
Summary: The apoptosis inducing receptor CD95/Fas has multiple tumorigenic activities. In different genetically engineered mouse models tumor-expressed CD95 was shown to be critical for cell growth.
Abdul S. Qadir, Jean Philippe Guégan, Christophe Ginestier, Assia Chaibi, Alban Bessede, Emmanuelle Charafe-Jauffret, Manon Macario, Vincent Lavoué, Thibault de la Motte Rouge, Calvin Law, Jacob Vilker, Hongbin Wang, Emily Stroup, Matthew J. Schipma, Bryan Bridgeman, Andrea E. Murmann, Zhe Ji, Patrick Legembre, Marcus E. Peter   +18 more
doaj   +2 more sources

IRE1 RNase controls CD95-mediated cell death

EMBO Reports
Signalling by the Unfolded Protein Response (UPR) or by the Death Receptors (DR) are frequently activated towards pro-tumoral outputs in cancer. Herein, we demonstrate that the UPR sensor IRE1 controls the expression of the DR CD95/Fas, and its cell ...
Diana Pelizzari-Raymundo, Victoria Maltret, Manon Nivet, Raphael Pineau, Alexandra Papaioannou, Xingchen Zhou, Flavie Caradec, Sophie Martin, Matthieu Le Gallo, Tony Avril, Eric Chevet, Elodie Lafont   +11 more
doaj   +2 more sources

CD95 signaling in colorectal cancer

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, 2012
CD95 and its ligand (CD95L) are widely expressed in colorectal tumors, but their role in shaping tumor behavior is unclear. CD95 activation on tumor cells can lead to apoptosis, while CD95L attracts neutrophils, suggesting a function in tumor suppression.
Hoogwater, Frederik J. H., Steller, Ernst J. A., Westendorp, B. Florien, Borel Rinkes, Inne H. M., Kranenburg, Onno   +4 more
openaire   +4 more sources

Tumor promoting effects of CD95 signaling in chemoresistant cells [PDF]

Molecular Cancer, 2010
Background CD95 is a death receptor controlling not only apoptotic pathways but also activating mechanisms promoting tumor growth. During the acquisition of chemoresistance to oxaliplatin there is a progressive loss of CD95 expression in colon cancer ...
Almendro Vanessa, Gascón Pedro, Pastor-Arroyo Eva, Carbó Neus, Fernández-Nogueira Patricia, Costamagna Domizziana, Mayordomo Cristina, García-Recio Susana, Ametller Elisabet   +8 more
doaj   +2 more sources

The role of CD95 and CD95 ligand in cancer [PDF]

Cell Death & Differentiation, 2015
CD95 (Fas/APO-1) and its ligand, CD95L, have long been viewed as a death receptor/death ligand system that mediates apoptosis induction to maintain immune homeostasis. In addition, these molecules are important in the immune elimination of virus-infected cells and cancer cells. CD95L was, therefore, considered to be useful for cancer therapy.
M E Peter, A Hadji, A E Murmann, S Brockway, W Putzbach, A Pattanayak, P Ceppi   +6 more
openaire   +2 more sources

CD95/Fas suppresses NF-κB activation through recruitment of KPC2 in a CD95L/FasL-independent mechanism

iScience, 2021
Summary: CD95 expression is preserved in triple-negative breast cancers (TNBCs), and CD95 loss in these cells triggers the induction of a pro-inflammatory program, promoting the recruitment of cytotoxic NK cells impairing tumor growth.
Jean-Philippe Guégan, Justine Pollet, Christophe Ginestier, Emmanuelle Charafe-Jauffret, Marcus E. Peter, Patrick Legembre   +5 more
doaj   +1 more source

Precise mapping of the CD95 pre-ligand assembly domain. [PDF]

PLoS ONE, 2012
Pre-association of CD95 at the plasma membrane is mandatory for efficient death receptor signaling. This homotrimerization occurs through self-association of an extracellular domain called the pre-ligand assembly domain (PLAD).
Valérie Edmond, Benoist Ghali, Aubin Penna, Jean-Luc Taupin, Sophie Daburon, Jean-François Moreau, Patrick Legembre   +6 more
doaj   +1 more source