Results 81 to 90 of about 58,729 (255)

Fas and Fas-ligand expression in fetal and adult human testis with normal or deranged spermatogenesis.

, 2000
In mice, the Fas/Fas ligand (FasL) system has been shown to be involved in germ cell apoptosis. In the present study we evaluated the expression of Fas and Fas ligand (FasL) in fetal and adult human testis.
D'ABRIZIO P, SILVANO G, STRAFACE E, GNESSI, Lucio, FRANCAVILLA S, ARIZZI M, ULISSE, SALVATORE, CORDESCHI G, RUCCI N, PROPERZI E   +9 more
core   +2 more sources

JAK-Mediated Signaling Inhibits Fas Ligand-Induced Apoptosis Independent of De Novo Protein Synthesis [PDF]

The Journal of Immunology, 2005
Abstract There is a growing appreciation for how cells integrate and appropriately respond to competing signals for proliferation and apoptosis. The studies described in this report examined the effects of exposure to the cytokine IFN-α (IFN-α-2a) on sensitivity of the human cell lines H9 and SKW6.4 to Fas ligand (FasL)-induced ...
Leslie P, Cousens, Frederick A, Goulette, James W, Darnowski   +2 more
openaire   +2 more sources

Distinct requirements for activation-induced cell surface expression of preformed Fas/CD95 ligand and cytolytic granule markers in T cells

, 2009
Fas (CD95/Apo-1) ligand is a potent inducer of apoptosis and one of the major killing effector mechanisms of cytotoxic T cells. Thus, Fas ligand activity has to be tightly regulated, involving various transcriptional and post-transcriptional processes ...
Conus, S, Simon, H-U, T Brunner, Brunner, Thomas, Micheau, Olivier, Nachbur, Ueli, P Schneider, U Nachbur, O Micheau, Brunner, T., Brunner, T, Conus, Sébastien, S Conus, Simon, H.U., D Kassahn, Kassahn, Daniela, H-U Simon, Conus, S., Kassahn, D, Micheau, O, Nachbur, U., Schneider, P., Simon, Hans-Uwe, Micheau, O., Nachbur, U, Schneider, P, Schneider, Pascal, Kassahn, D.   +27 more
core   +1 more source

TRAIL receptor signaling regulation of chemosensitivity in vivo but not in vitro. [PDF]

PLoS ONE, 2011
Signaling by Tumor Necrosis Factor-Related Apoptosis Inducing Ligand (TRAIL) and Fas ligand (FasL) has been proposed to contribute to the chemosensitivity of tumor cells treated with various other anti-cancer agents.
Christina Menke, Tatiana Goncharov, Lubna Qamar, Christopher Korch, Heide L Ford, Kian Behbakht, Andrew Thorburn   +6 more
doaj   +1 more source

Binding of the Intracellular Fas Ligand (FasL) Domain to the Adaptor Protein PSTPIP Results in a Cytoplasmic Localization of FasL [PDF]

Journal of Biological Chemistry, 2005
The tumor necrosis factor family member Fas ligand (FasL) induces apoptosis in Fas receptor-expressing target cells and is an important cytotoxic effector molecule used by CTL- and NK-cells. In these hematopoietic cells, newly synthesized FasL is stored in specialized secretory lysosomes and only delivered to the cell surface upon activation and target
Baum, Wiebke, Kirkin, Vladimir, Mateus Fernández, Sara, Pick, Robert, Lettau, Marcus, Janssen, Ottmar Johannes, Zörnig, Martin   +6 more
openaire   +3 more sources

Bid participates in genotoxic drug-induced apoptosis of HeLa cells and is essential for death receptor ligands' apoptotic and synergistic effects

, 2008
Background: The BH3-only protein Bid is an important component of death receptor-mediated caspase activation. Bid is cleaved by caspase-8 or -10 into t-Bid, which translocates to mitochondria and triggers the release of caspase-activating factors.
Caoimhin G Concannon, Anguissola, Sergio, Barbara Köhler, Jochen H M Prehn, Markus Rehm (7899308), Kögel, Donat, Barbara Köhler (60110), Caoimhín G. Concannon (7953038), Donat Kögel, Sergio Anguissola, Prehn, Jochen H. M., Donat Kögel (60113), Köhler, Barbara, Rehm, Markus, Sergio Anguissola (60111), Jochen Prehn (7895672), Concannon, Caoimhin G., Markus Rehm   +17 more
core   +1 more source

Immune Checkpoint Inhibitors Induce Intestinal Epithelial Injury and a Senescence‐Like Phenotype

iNew Medicine, EarlyView.
ICI treatment promotes the infiltration of activated immune cells into the intestinal mucosa. This inflammatory microenvironment is associated with significant epithelial injury, characterized by the disruption of the epithelial barrier, the depletion of specialized secretory cell lineages, and the induction of a premature senescence phenotype ...
Juan Wang, Shuang Wu, Shuangbiao Wei, Weizhen Xiang, Jianshang Huang, Lei Xiong, Hua Wang, Li Zuo   +7 more
wiley   +1 more source

Babao Dan induces gastric cancer cell apoptosis via regulating MAPK and NF-κB signaling pathways

Journal of International Medical Research, 2019
Objective The objective was to further investigate apoptosis induction by Babao Dan (BBD), which supports its anti-tumor mechanisms, using two human gastric cancer cell lines (AGS and MGC80-3).
Haixia Shang, Zhiyun Cao, Jinyan Zhao, Jianhua Guan, Jianxin Liu, Jun Peng, Youqin Chen, Thomas Joseph Sferra, Senthilkumar Sankararaman, Jiumao Lin   +9 more
doaj   +1 more source

Hepatic ATGL mediates PPAR-α signaling and fatty acid channeling through an L-FABP independent mechanism

Journal of Lipid Research, 2014
Adipose TG lipase (ATGL) catalyzes the rate-limiting step in TG hydrolysis in most tissues. We have shown that hepatic ATGL preferentially channels hydrolyzed FAs to β-oxidation and induces PPAR-α signaling.
Kuok Teong Ong, Mara T. Mashek, Nicholas O. Davidson, Douglas G. Mashek   +3 more
doaj   +1 more source

Airway epithelial Fas ligand expression: potential role in modulating bronchial inflammation

, 1998
Epithelium-derived Fas ligand is believed to modulate inflammation within various tissues. In this paper, we report findings that suggest a similar immunoregulatory role for Fas ligand in the lung.
Antoon J. M. Van Oosterhout, Bernadette R. Gochuico, William W. Cruikshank, Kathleen M. Miranda, Alan Fine, Joris J. De Bie, Edith M. Hessel   +6 more
core   +1 more source