Results 61 to 70 of about 57,038 (163)

Apoptosis and apoptosis-related proteins (Fas, Fas ligand, bcl-2, p53) in macrophages of human ovarian epithelial tumors.

European journal of gynaecological oncology, 2000
Apoptosis and the apoptosis-related proteins (ARP) (Fas, Fas ligand (FasL), bcl-2 and p53) were analyzed in macrophages of different human ovarian epithelial tumors. Few macrophages were found in ovaries of women without oncologic disorders. In ovarian benign cysts, macrophagic density reached 4.9+/-1.2 per 50,000 microm2, most were present in lymphoid-
H, Ben-Hur, P, Gurevich, A, Ben-Arie, M, Huszar, V, Berman, Y, Tendler, R, Tchanishev, G, Mor, S, Gershon, I, Zusman   +9 more
openaire   +2 more sources

Hepatic ATGL mediates PPAR-α signaling and fatty acid channeling through an L-FABP independent mechanism

Journal of Lipid Research, 2014
Adipose TG lipase (ATGL) catalyzes the rate-limiting step in TG hydrolysis in most tissues. We have shown that hepatic ATGL preferentially channels hydrolyzed FAs to β-oxidation and induces PPAR-α signaling.
Kuok Teong Ong, Mara T. Mashek, Nicholas O. Davidson, Douglas G. Mashek   +3 more
doaj   +1 more source

Inhibition of Insulin-like Growth Factor 1 Receptor Signaling Enhanced Silibinin-Induced Activation of Death Receptor and Mitochondrial Apoptotic Pathways in Human Breast Cancer MCF-7 Cells

Journal of Pharmacological Sciences, 2008
Silibinin, which had been used as a hepatoprotectant, was shown to have anticancer activity. In this study we investigated the mechanisms of silibinin-induced apoptosis in human breast cancer MCF-7 cells.
Hong-jun Wang, Shin-ichi Tashiro, Satoshi Onodera, Takashi Ikejima   +3 more
doaj   +1 more source

Engineering donor lymphocytes with Fas ligand protein effectively prevents acute graft-versus-host disease. [PDF]

Blood Adv, 2023
Shrestha P, Turan A, Batra L, Gulen AE, Sun Z, Tan H, Askenasy N, Shirwan H, Yolcu ES.   +8 more
europepmc   +1 more source

Low concentration of ethanol induce apoptosis in HepG2 cells: role of various signal transduction pathways

International Journal of Medical Sciences, 2006
As we previously demonstrated in human hepatocellular carcinoma (HepG2) cells, ethanol at low concentration triggers the Fas apoptotic pathway. However, its role in other intracellular signaling pathways remains unknown. Therefore, the aim of the present
Francisco Castaneda, Sigrid Rosin-Steiner
doaj  

Combined effects of 17β-estradiol and exercise training on cardiac apoptosis in ovariectomized rats.

PLoS ONE, 2018
BACKGROUND:The purpose of this study was to investigate the combined 17β-estradiol (E2) and exercise training on cardiac pro-survival and anti-apoptotic pathways in ovariectomized rats.
Yi-Yuan Lin, Jwo-Sheng Chen, Xu-Bo Wu, Woei-Cherng Shyu, Rungchai Chaunchaiyakul, Xian-Li Zhao, Chia-Hua Kuo, Yu-Jung Cheng, Ai-Lun Yang, Shin-Da Lee   +9 more
doaj   +1 more source

Apoptosis and apoptosis-related proteins (Fas, Fas ligand, Blc-2, p53) in lymphoid elements of human ovarian tumors.

European journal of gynaecological oncology, 2000
Different types of lymphocytes have different roles in tumor suppression. Thus, their expression of apoptosis-related proteins (ARP - Fas and Fas ligand, bcl-2, p53) in lymphocytes and their apoptosis were analyzed immunohistochemically in ovarian tumors of different grades.
H, Ben-Hur, P, Gurevich, M, Huszar, A, Ben-Arie, V, Berman, Y, Tendler, O, Zinder, R, Tchanishev, S, Gershon, G, Mor, Y, Zaltsman, F, Kohen, I, Zusman   +12 more
openaire   +1 more source

Lymphoid elements and apoptosis-related proteins (Fas, Fas ligand, p53 and bcl-2) in lichen sclerosus and carcinoma of the vulva.

European journal of gynaecological oncology, 2001
We studied some of the morphological and immunohistochemical parameters of lichen sclerosus (LS) and carcinomas of the vulva in order to verify some characteristics in LS related to neoplasm transformation. Parameters such as proliferating index, rate of proliferation of lymphoid elements into a tumor and types of such elements were studied.
H, Ben-Hur, M, Ashkenazi, M, Huszar, P, Gurevich, I, Zusman   +4 more
openaire   +1 more source

Fas ligand interacting proteins : new insights into complex signaling networks [PDF]

, 2005
The Fas ligand is a death factor and a potential signal transducer. Here we show the retrograde signaling of FasL could be demonstrated in human T cells. FasL engagement results in a severe block of T cell activation without increased cell death. In cytotoxic T cells, NK cells , FasL can be located intracellularly in 'secretory lysosomes' and delivered
openaire  

Immunohistochemical expression of Fas/Fasligand and c-Myc in oral lichen planus

Journal of Baghdad College of Dentistry, 2014
Background: Oral Lichen Planus is a chronic inflammatory mucosal disease, presenting in various clinical forms .Both antigen-specific and non-specific mechanisms involved in the pathogenesis of OLP.
Abdul-Razzaq A M Wahhab, Riyadh O Alkaisi   +1 more
doaj