Results 61 to 70 of about 58,729 (255)

Targeting a Myeloid–Regulatory B Cell Network Reverses Immune Paralysis in Periprosthetic Joint Infections

Advanced Science, EarlyView.
Periprosthetic joint infection establishes a sophisticated immunosuppressive network between CXCR4+ PMN‐MDSCs and Bregs, inducing profound CD8+ T cell paralysis. Alendronate effectively disrupts this CXCR4+ PMN‐MDSC–Breg axis by targeting STAT3, thereby restoring local immune surveillance.
Jintao Wu, Shutao Zhang, Yumin Lin, Juyang Jiao, Zhiwei Fu, Qimin Hong, Ziyi Zhao, Xinhua Qu, Fei Su, Bing Yue   +9 more
wiley   +1 more source

PMA and ionomycin induce glioblastoma cell death: activation-induced cell-death-like phenomena occur in glioma cells. [PDF]

PLoS ONE, 2013
Phorbol myristate acetate (PMA) and ionomycin (Io) can induce T cell activation and proliferation. Furthermore, they stimulate activation-induced cell death (AICD) in mature lymphocytes via Fas/Fas ligand (FasL) up-regulation.
Sheng Han, Xinxin Tie, Lingxuan Meng, Yunjie Wang, Anhua Wu   +4 more
doaj   +1 more source

HIV Tat Binds Egr Proteins and Enhances Egr-dependent Transactivation of the Fas Ligand Promoter [PDF]

Journal of Biological Chemistry, 2002
HIV Tat can enhance activation-induced up-regulation of Fas ligand (FasL), which may contribute to T cell apoptosis in human immune deficiency virus (HIV)-infected individuals. We have assessed functional and physical interactions between Tat and the Egr family of transcription factors (Egr-1, -2, and -3), the latter two of which are major participants
Yili, Yang, Bei, Dong, Paul R, Mittelstadt, Hua, Xiao, Jonathan D, Ashwell   +4 more
openaire   +2 more sources

Porcine kidney xenotransplantation: From primate models to clinical reality

Animal Models and Experimental Medicine, EarlyView.
In the face of a critical shortage of human donor kidneys for end‐stage renal disease patients, porcine kidney xenotransplantation has emerged as a viable solution. This field has navigated major hurdles, including immune rejection, physiological incompatibilities, potential biomechanical differences and the risk of cross‐species infection. To overcome
Zihang Guo, Ling Zhang, Shoulong Deng, Chuan Qin   +3 more
wiley   +1 more source

Apoptosis Transcriptional Profile Induced by Porphyromonas gingivalis HmuY

Mediators of Inflammation, 2019
This study aimed at evaluating the transcriptional profile of apoptosis-related genes after in vitro stimulation of peripheral blood mononuclear cells (PBMCs) derived from individuals with periodontitis (P) and healthy nonperiodontitis (NP) control ...
Paulo C. Carvalho-Filho, Lilia F. Moura-Costa, Ana C. M. Pimentel, Mabel P. P. Lopes, Sibelle A. Freitas, Patrícia M. Miranda, Ryan S. Costa, Camila A. V. Figueirêdo, Roberto Meyer, Isaac S. Gomes-Filho, Teresa Olczak, Márcia T. Xavier, Soraya C. Trindade   +12 more
doaj   +1 more source

Effector and naturally occurring regulatory T cells display no abnormalities in activation induced cell death in NOD mice. [PDF]

PLoS ONE, 2011
BACKGROUND: Disturbed peripheral negative regulation might contribute to evolution of autoimmune insulitis in type 1 diabetes. This study evaluates the sensitivity of naïve/effector (Teff) and regulatory T cells (Treg) to activation-induced cell death ...
Ayelet Kaminitz, Esma S Yolcu, Enosh M Askenasy, Jerry Stein, Isaac Yaniv, Haval Shirwan, Nadir Askenasy   +6 more
doaj   +1 more source

Nuclear factor of activated T cells as a driver of tumor progression and a target for precision therapy

Animal Models and Experimental Medicine, EarlyView.
Overview illustration of dysregulated NFAT activation coordinating upstream signaling, post‐translational regulation and cancer promoting pathways to induce abnormal gene expression that drives tumor development, progression and immune escape. Abstract The Nuclear Factor of Activated T Cells (NFAT) family comprises closely related transcription factors.
Hira Khan, Khushbakhat Alia, Yusra Al Dhaheri, Muhammad Naseem, Rabah Iratni, Edgar Serfling, Khalid Muhammad   +6 more
wiley   +1 more source

Intrahepatic mRNA Expression of FAS, FASL, and FOXP3 Genes Is Associated with the Pathophysiology of Chronic HCV Infection. [PDF]

PLoS ONE, 2016
UNLABELLED:This study aimed to evaluate the relative mRNA expression of Fas receptor (FAS), Fas ligand (FASL), and forkhead box protein 3 (FOXP3) in liver biopsy specimens obtained from patients with viral and non-viral chronic hepatitis and correlate ...
Ednelza da Silva Graça Amoras, Samara Tatielle Monteiro Gomes, Felipe Bonfim Freitas, Bárbara Brasil Santana, Geraldo Ishak, Marialva Tereza Ferreira de Araújo, Sâmia Demachki, Simone Regina Souza da Silva Conde, Marluísa de Oliveira Guimarães Ishak, Ricardo Ishak, Antonio Carlos Rosário Vallinoto   +10 more
doaj   +1 more source

Pigment Epithelial-derived Factor (PEDF)-triggered Lung Cancer Cell Apoptosis Relies on p53 Protein-driven Fas Ligand (Fas-L) Up-regulation and Fas Protein Cell Surface Translocation [PDF]

Journal of Biological Chemistry, 2014
Pigment epithelium-derived factor (PEDF), a potent antiangiogenesis agent, has recently attracted attention for targeting tumor cells in several types of tumors. However, less is known about the apoptosis-inducing effect of PEDF on human lung cancer cells and the underlying molecular events.
Lei, Li, Ya-Chao, Yao, Shu-Huan, Fang, Cai-Qi, Ma, Yi, Cen, Zu-Min, Xu, Zhi-Yu, Dai, Cen, Li, Shuai, Li, Ting, Zhang, Hong-Hai, Hong, Wei-Wei, Qi, Ti, Zhou, Chao-Yang, Li, Xia, Yang, Guo-Quan, Gao   +15 more
openaire   +2 more sources

Efficacy, safety and cost‐effectiveness of CAR‐T therapy

British Journal of Clinical Pharmacology, EarlyView.
CAR T‐cells demonstrate high efficacy in blood cancers, including ALL, MM and DLBCL. Innovations target solid tumours despite challenges such as antigen escape. Combination therapies enhance the delivery and infiltration of CAR T cells. Toxicity, cost and resistance remain major barriers to clinical use.
Emina Karahmet Sher, Amina Džidić‐Krivić, Emma Pinjic, Nejra Selak, Kanita Omerbasic, Alexandar Chupin, Andrej Belancic, Almir Fajkic   +7 more
wiley   +1 more source