Results 31 to 40 of about 58,729 (255)

Dominant inhibition of Fas ligand-mediated apoptosis due to a heterozygous mutation associated with autoimmune lymphoproliferative syndrome (ALPS) Type Ib

BMC Medical Genetics, 2007
Background: Autoimmune lymphoproliferative syndrome (ALPS) is a disorder of lymphocyte homeostasis and immunological tolerance due primarily to genetic defects in Fas (CD95/APO-1; TNFRSF6), a cell surface receptor that regulates apoptosis and its ...
McDonald Jay M, Reddy Vishnu, Makris Christopher, Dale Janet K, Zheng Lixin, Atkinson T Prescott, Pan George, Bi Lilia L, Siegel Richard M, Puck Jennifer M, Lenardo Michael J, Straus Stephen E   +11 more
doaj   +1 more source

Identification of the Calmodulin-Binding Domains of Fas Death Receptor. [PDF]

PLoS ONE, 2016
The extrinsic apoptotic pathway is initiated by binding of a Fas ligand to the ectodomain of the surface death receptor Fas protein. Subsequently, the intracellular death domain of Fas (FasDD) and that of the Fas-associated protein (FADD) interact to ...
Bliss J Chang, Alexandra B Samal, Jiri Vlach, Timothy F Fernandez, Dewey Brooke, Peter E Prevelige, Jamil S Saad   +6 more
doaj   +1 more source

Type-I interferon is critical for FasL expression on lung cells to determine the severity of influenza. [PDF]

PLoS ONE, 2013
Infection of influenza A virus in mammals induces hyper lung pneumonia, which often causes lethal diseases. FasL is a specific ligand of Fas, which is a type-I transmembrane protein to induce cell death.
Daisuke Fujikura, Satoko Chiba, Daisuke Muramatsu, Mika Kazumata, Yosuke Nakayama, Taro Kawai, Shizuo Akira, Hiroshi Kida, Tadaaki Miyazaki   +8 more
doaj   +1 more source

CD40 ligand induced cytotoxicity in carcinoma cells is enhanced by inhibition of metalloproteinase cleavage and delivery via a conditionally-replicating adenovirus [PDF]

, 2010
Background CD40 and its ligand (CD40L) play a critical role in co-ordinating immune responses. CD40 is also expressed in lymphoid malignancies and a number of carcinomas. In carcinoma cells the physiological outcome of CD40 ligation depends on the level
Young Lawrence S, Elmetwali, Taha, Mcneish, I., Searle Peter F, Young, Lawrence, Searle, PF, Palmer Daniel H, McNeish, I, Young, Lawrence S., Palmer, D.H., McNeish, Iain, Peter F Searle, Lawrence S Young, Elmetwali, T., Searle, P.F., Elmetwali Taha, Iain McNeish, Young, LS, McNeish Iain, Palmer, Daniel H., Palmer, DH, Searle, Peter F., Daniel H Palmer, Young, L.S., Taha Elmetwali, Palmer, Daniel, Searle, Peter, Elmetwali, T   +27 more
core   +1 more source

Microparticles from patients with metabolic syndrome induce vascular hypo-reactivity via Fas/Fas-ligand pathway in mice [PDF]

, 2011
Peer ...
Andriantsitohaina Ramaroson, Benameur, Tarek, Tarek Benameur, Olga Pechanova, Martinez, Maria Carmen, S. Faure, M. Sladkova, Pechanova Olga, Faure Sébastien, Delibegovic Mirela, Pechanova, Olga, Lucie Duluc, Delibegovic, Mirela, Agouni Abdelali, Sladkova Martina, Duluc Lucie, Martinez Maria Carmen, Pierre-Henri Ducluzeau, Martina Sladkova, L. Duluc, Georges Leftheriotis, Duluc, Lucie, Mirela Delibegovic, M.C. Martinez, M. Delibegović, P.H. Ducluzeau-Fieloux, Agouni, Abdelali, Abdelali Agouni, O. Pechanova, Benameur Tarek, Andriantsitohaina, Ramaroson, Sladkova, Martina, A. Agouni, Leftheriotis, Georges, Faure, Sebastien, Ramaroson Andriantsitohaina, Ducluzeau Pierre-Henri, R. Andriantsitohaina, G. Lefthériotis, Maria Carmen Martinez, T. Benameur, Sébastien Faure, Ducluzeau, Pierre-Henri, Leftheriotis Georges   +43 more
core   +1 more source

Transcriptional Regulation of Neuronal Genes and Its Effect on Neural Functions: Expression and Function of Forkhead Transcription Factors in Neurons

Journal of Pharmacological Sciences, 2005
Forkhead box transcription factor, class O (FOXO) is a mammalian homologue of DAF-16, which is known to regulate the lifespan of Caenorhabditis elegans and includes subfamilies of forkhead transcription factors such as AFX, FKHRL1, and FKHR.
Kohji Fukunaga, Takao Ishigami, Takayuki Kawano   +2 more
doaj   +1 more source

FAS receptor regulates NOTCH activity through ERK-JAG1 axis activation and controls oral cancer stemness ability and pulmonary metastasis

Cell Death Discovery, 2022
Pulmonary metastasis occurring via the colonization of circulating cancer stem cells is a major cause of oral squamous cell carcinoma (OSCC)-related death.
Li-Jie Li, Peter Mu-Hsin Chang, Chien-Hsiu Li, Yu-Chan Chang, Tsung-Ching Lai, Chia-Yi Su, Chi-Long Chen, Wei-Min Chang, Michael Hsiao, Sheng-Wei Feng   +9 more
doaj   +1 more source

CD95 co-stimulation blocks activation of naive T cells by inhibiting T cell receptor signaling [PDF]

, 2009
CD95 is a multifunctional receptor that induces cell death or proliferation depending on the signal, cell type, and cellular context. Here, we describe a thus far unknown function of CD95 as a silencer of T cell activation.
Lindquist, Jonathan, Strauss, Gudrun, Lindquist, Jonathan A., Arhel, Nathalie, Nathalie Arhel, Tobias L. Haas, Edward Felder, Fulda, Simone, Haas, Tobias L., Henning Walczak, Felder, Edward, Kirchhoff, Frank, Gudrun Strauss, Sabine Karl, Simone Fulda, Walczak, Henning, Karl, Sabine, Frank Kirchhoff, Klaus-Michael Debatin, Debatin, Klaus-Michael, Jonathan A. Lindquist, Haas, Tobias   +21 more
core   +1 more source

Periodontal diseases and adverse pregnancy outcomes. Present and future

Periodontology 2000, EarlyView., 2023
Abstract For more than two decades the possible association between periodontal diseases and adverse pregnancy outcomes has been extensively evaluated. Numerous observational, intervention, and mechanistic studies have offered valuable information on this topic.
Yiorgos A. Bobetsis, Mark Ide, Mervi Gürsoy, Phoebus N. Madianos   +3 more
wiley   +1 more source

Fas/FasL expression in colorectal cancer. An immunohistochemical study.

Folia Histochemica et Cytobiologica, 2010
The objective of the current study was to assess the expression of Fas ligand (FasL) and Fas receptor (FasR) as the proteins of the post-mitochondrial apoptotic pathway in colorectal carcinoma and to investigate correlations between their expression and ...
Katarzyna Guzińska-Ustymowicz, Anna Pryczynicz, Andrzej Kemona   +2 more
doaj   +1 more source