FAS-dependent cell death in α-synuclein transgenic oligodendrocyte models of multiple system atrophy. [PDF]
PLoS ONE, 2013 Multiple system atrophy is a parkinsonian neurodegenerative disorder. It is cytopathologically characterized by accumulation of the protein p25α in cell bodies of oligodendrocytes followed by accumulation of aggregated α-synuclein in so-called glial ...
Christine L Kragh +12 more
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Display of Fas Ligand Protein on Cardiac Vasculature as a Novel Means of Regulating Allograft Rejection [PDF]
Circulation, 2003 Background— Fas ligand (FasL) is a potent death-inducing molecule with important functions in immune homeostasis and tolerance to self-antigens. The complex biological activities of FasL and its inefficient expression using conventional gene transfer approaches limit its use for immunomodulation to ...
Nadir, Askenasy +3 more
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Fas/FasL expression in colorectal cancer. An immunohistochemical study.
Folia Histochemica et Cytobiologica, 2010 The objective of the current study was to assess the expression of Fas ligand (FasL) and Fas receptor (FasR) as the proteins of the post-mitochondrial apoptotic pathway in colorectal carcinoma and to investigate correlations between their expression and ...
Katarzyna Guzińska-Ustymowicz +2 more
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Alteration of Regulation of Fas/FasL Mediated Apoptosis in Gastric Cancer [PDF]
Revista Ciencias de la Salud, 2009 Gastric cancer is an important neoplasticdisease in all around the world because its highincidence and mortality. Otherwise, apoptosis isa key process of programmed cell death duringembryogenesis, regulation of immune system,and holding the tissue ...
Reggie García Robles +2 more
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BMC Biotechnology, 2017 Background Fas ligand plays a key role in the human immune system as a major cell death inducing protein. The extracellular domain of human Fas ligand (hFasLECD) triggers apoptosis of malignant cells, and therefore is expected to have substantial ...
Michiro Muraki, Kiyonori Hirota
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FLASH knockdown sensitizes cells to Fas-mediated apoptosis via down-regulation of the anti-apoptotic proteins, MCL-1 and Cflip short. [PDF]
PLoS ONE, 2012 FLASH (FLICE-associated huge protein or CASP8AP2) is a large multifunctional protein that is involved in many cellular processes associated with cell death and survival.
Song Chen +2 more
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Fas activates lipolysis in a Ca2+-CaMKII-dependent manner in 3T3-L1 adipocytes[S]
Journal of Lipid Research, 2013 Fas (CD95) is a member of the tumor necrosis factor (TNF) receptor superfamily and plays a crucial role in the induction of apoptosis. However, like TNF, Fas can induce nonapoptotic signaling pathways.
Reto A. Rapold +4 more
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Apoptosis and upregulation of TNF-α and TRAIL receptor 1 (DR4) in the pathogenesis of food protein-induced enterocolitis syndrome [PDF]
Korean Journal of Pediatrics, 2010 Purpose : Expression levels of tumor necrosis factor (TNF)-?#6181;xpression on the mucosa of the small intestine is increased in patients with villous atrophy in food protein-induced enterocolitis syndrome (FPIES).
Jin-Bok Hwang +5 more
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Soluble Fas ligand drives autoantibody-induced arthritis by binding to DR5/TRAIL-R2
eLife, 2021 To date, no study has demonstrated that soluble Fas ligand (sFasL)-mediated inflammation is regulated via interaction with Fas in vivo. We found that FasL interacts specifically with tumor necrosis factor receptor superfamily (TNFRSF)10B, also known as ...
Dongjin Jeong +15 more
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Fatty Acid Binding to Human Serum Albumin in Blood Serum Characterized by EPR Spectroscopy
ChemistryOpen, 2019 One of the functions of Human Serum Albumin (HSA) is binding and transport of fatty acids. This ability could be altered by the presence of several blood components such as toxins or peptides – which in turn alters the functionality of the protein.
Dr. Haleh H. Haeri +5 more
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