Results 21 to 30 of about 57,038 (163)

Serum soluble Fas ligand is a severity and mortality prognostic marker for COVID-19 patients

Frontiers in Immunology, 2022
Finding cytokine storm initiator factors associated with uncontrolled inflammatory immune response is necessary in COVID-19 patients. The aim was the identification of Fas/Fas Ligand (FasL) role in lung involvement and mortality of COVID-19 patients.
Kiarash Saleki, Kiarash Saleki, Kiarash Saleki, Kiarash Saleki, Moein Shirzad, Moein Shirzad, Moein Shirzad, Mostafa Javanian, Sheyda Mohammadkhani, Mohammad Hossein Alijani, Niloufarsadat Miri, Morteza Oladnabi, Abbas Azadmehr, Abbas Azadmehr, Abbas Azadmehr   +14 more
doaj   +1 more source

Role of P38 Mitogen-Activated Protein Kinase Phosphorylation and Fas-Fas Ligand Interaction in Morphine-Induced Macrophage Apoptosis [PDF]

The Journal of Immunology, 2002
Abstract In this study, we evaluated the molecular mechanisms involved in morphine-induced macrophage apoptosis. Both morphine and TGF-β promoted P38 mitogen-activated protein kinase (MAPK) phosphorylation, and this phosphorylation was inhibited by SB 202190 as well as by SB 203580.
Pravin C, Singhal, Madhu, Bhaskaran, Jaimita, Patel, Kalpesh, Patel, Balakuntalam S, Kasinath, Senthil, Duraisamy, Nicholas, Franki, Krishna, Reddy, Aditi A, Kapasi   +8 more
openaire   +2 more sources

Effect of adjuvant therapy with ginkgo-damole on apoptosis, nerve injury and platelet aggregation of patients with acute cerebral infarction

Journal of Acute Disease, 2017
Objective: To investigate the effect of adjuvant therapy with ginkgo-damole on apoptosis, nerve injury and platelet aggregation of patients with acute cerebral infarction.
Zhi-Yong Lu
doaj   +1 more source

Deregulation of Fas ligand expression as a novel cause of autoimmune lymphoproliferative syndrome-like disease

Haematologica, 2015
Autoimmune lymphoproliferative syndrome is frequently caused by mutations in genes involved in the Fas death receptor pathway, but for 20–30% of patients the genetic defect is unknown.
Schafiq Nabhani, Sebastian Ginzel, Hagit Miskin, Shoshana Revel-Vilk, Dan Harlev, Bernhard Fleckenstein, Andrea Hönscheid, Prasad T. Oommen, Michaela Kuhlen, Ralf Thiele, Hans-Jürgen Laws, Arndt Borkhardt, Polina Stepensky, Ute Fischer   +13 more
doaj   +1 more source

Dominant inhibition of Fas ligand-mediated apoptosis due to a heterozygous mutation associated with autoimmune lymphoproliferative syndrome (ALPS) Type Ib

BMC Medical Genetics, 2007
Background: Autoimmune lymphoproliferative syndrome (ALPS) is a disorder of lymphocyte homeostasis and immunological tolerance due primarily to genetic defects in Fas (CD95/APO-1; TNFRSF6), a cell surface receptor that regulates apoptosis and its ...
McDonald Jay M, Reddy Vishnu, Makris Christopher, Dale Janet K, Zheng Lixin, Atkinson T Prescott, Pan George, Bi Lilia L, Siegel Richard M, Puck Jennifer M, Lenardo Michael J, Straus Stephen E   +11 more
doaj   +1 more source

Identification of the Calmodulin-Binding Domains of Fas Death Receptor. [PDF]

PLoS ONE, 2016
The extrinsic apoptotic pathway is initiated by binding of a Fas ligand to the ectodomain of the surface death receptor Fas protein. Subsequently, the intracellular death domain of Fas (FasDD) and that of the Fas-associated protein (FADD) interact to ...
Bliss J Chang, Alexandra B Samal, Jiri Vlach, Timothy F Fernandez, Dewey Brooke, Peter E Prevelige, Jamil S Saad   +6 more
doaj   +1 more source

Type-I interferon is critical for FasL expression on lung cells to determine the severity of influenza. [PDF]

PLoS ONE, 2013
Infection of influenza A virus in mammals induces hyper lung pneumonia, which often causes lethal diseases. FasL is a specific ligand of Fas, which is a type-I transmembrane protein to induce cell death.
Daisuke Fujikura, Satoko Chiba, Daisuke Muramatsu, Mika Kazumata, Yosuke Nakayama, Taro Kawai, Shizuo Akira, Hiroshi Kida, Tadaaki Miyazaki   +8 more
doaj   +1 more source

Interaction of the Adenovirus 14.7-kDa Protein with FLICE Inhibits Fas Ligand-induced Apoptosis [PDF]

Journal of Biological Chemistry, 1998
Adenovirus type 5 encodes a 14.7-kDa protein that protects infected cells from tumor necrosis factor-induced cytolysis by an unknown mechanism. In this report, we demonstrate that infection of cells with an adenovirus vector expressing Fas ligand induced rapid apoptosis that was blocked by coinfection with a virus expressing 14. 7K.
P, Chen, J, Tian, I, Kovesdi, J T, Bruder   +3 more
openaire   +2 more sources

Transcriptional Regulation of Neuronal Genes and Its Effect on Neural Functions: Expression and Function of Forkhead Transcription Factors in Neurons

Journal of Pharmacological Sciences, 2005
Forkhead box transcription factor, class O (FOXO) is a mammalian homologue of DAF-16, which is known to regulate the lifespan of Caenorhabditis elegans and includes subfamilies of forkhead transcription factors such as AFX, FKHRL1, and FKHR.
Kohji Fukunaga, Takao Ishigami, Takayuki Kawano   +2 more
doaj   +1 more source

FAS receptor regulates NOTCH activity through ERK-JAG1 axis activation and controls oral cancer stemness ability and pulmonary metastasis

Cell Death Discovery, 2022
Pulmonary metastasis occurring via the colonization of circulating cancer stem cells is a major cause of oral squamous cell carcinoma (OSCC)-related death.
Li-Jie Li, Peter Mu-Hsin Chang, Chien-Hsiu Li, Yu-Chan Chang, Tsung-Ching Lai, Chia-Yi Su, Chi-Long Chen, Wei-Min Chang, Michael Hsiao, Sheng-Wei Feng   +9 more
doaj   +1 more source