Results 21 to 30 of about 58,729 (255)

AIF1+CSF1R+ MSCs, induced by TNF‐α, act to generate an inflammatory microenvironment and promote hepatocarcinogenesis

Hepatology, EarlyView., 2022
Mesenchymal stem cells subset, educated by TNF‐α, are involved to generate inflammatory microenvironment and promote hepatocarcinogenesis Abstract Background and Aims Increasing evidence suggests that mesenchymal stem cells (MSCs) home to injured local tissues and the tumor microenvironment in the liver.
Chen Zong, Yan Meng, Fei Ye, Xue Yang, Rong Li, Jinghua Jiang, Qiudong Zhao, Lu Gao, Zhipeng Han, Lixin Wei   +9 more
wiley   +1 more source

The Mouse Cell Surface Protein TOSO Regulates Fas/Fas Ligand-induced Apoptosis through Its Binding to Fas-associated Death Domain [PDF]

Journal of Biological Chemistry, 2005
Mouse TOSO, the homologue of human TOSO gene, was cloned and characterized in the present study. Using immunofluorescence confocal microscopy we localized TOSO to the cytoplasmic membrane of expressing cells. Using stably transfected mouse TOSO (mTOSO)-expressing Jurkat cells, we show that TOSO protects cells from Fas/Fas ligand- and tumor necrosis ...
Yahui, Song, Chaim O, Jacob
openaire   +2 more sources

Role of P38 Mitogen-Activated Protein Kinase Phosphorylation and Fas-Fas Ligand Interaction in Morphine-Induced Macrophage Apoptosis [PDF]

The Journal of Immunology, 2002
Abstract In this study, we evaluated the molecular mechanisms involved in morphine-induced macrophage apoptosis. Both morphine and TGF-β promoted P38 mitogen-activated protein kinase (MAPK) phosphorylation, and this phosphorylation was inhibited by SB 202190 as well as by SB 203580.
Pravin C, Singhal, Madhu, Bhaskaran, Jaimita, Patel, Kalpesh, Patel, Balakuntalam S, Kasinath, Senthil, Duraisamy, Nicholas, Franki, Krishna, Reddy, Aditi A, Kapasi   +8 more
openaire   +2 more sources

Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening

BMC Immunology, 2009
Background - Fas ligand is a cytotoxic effector molecule of T and NK cells which is characterized by an intracellular N-terminal polyproline region that serves as a docking site for SH3 and WW domain proteins.
Lettau Marcus, Voss Matthias, Janssen Ottmar   +2 more
doaj   +1 more source

Interaction of the Adenovirus 14.7-kDa Protein with FLICE Inhibits Fas Ligand-induced Apoptosis [PDF]

Journal of Biological Chemistry, 1998
Adenovirus type 5 encodes a 14.7-kDa protein that protects infected cells from tumor necrosis factor-induced cytolysis by an unknown mechanism. In this report, we demonstrate that infection of cells with an adenovirus vector expressing Fas ligand induced rapid apoptosis that was blocked by coinfection with a virus expressing 14. 7K.
P, Chen, J, Tian, I, Kovesdi, J T, Bruder   +3 more
openaire   +2 more sources

Effect of adjuvant therapy with ginkgo-damole on apoptosis, nerve injury and platelet aggregation of patients with acute cerebral infarction

Journal of Acute Disease, 2017
Objective: To investigate the effect of adjuvant therapy with ginkgo-damole on apoptosis, nerve injury and platelet aggregation of patients with acute cerebral infarction.
Zhi-Yong Lu
doaj   +1 more source

Serum soluble Fas ligand is a severity and mortality prognostic marker for COVID-19 patients

Frontiers in Immunology, 2022
Finding cytokine storm initiator factors associated with uncontrolled inflammatory immune response is necessary in COVID-19 patients. The aim was the identification of Fas/Fas Ligand (FasL) role in lung involvement and mortality of COVID-19 patients.
Kiarash Saleki, Kiarash Saleki, Kiarash Saleki, Kiarash Saleki, Moein Shirzad, Moein Shirzad, Moein Shirzad, Mostafa Javanian, Sheyda Mohammadkhani, Mohammad Hossein Alijani, Niloufarsadat Miri, Morteza Oladnabi, Abbas Azadmehr, Abbas Azadmehr, Abbas Azadmehr   +14 more
doaj   +1 more source

Fas induces apoptosis in human coronary artery endothelial cells in vitro

BMC Cell Biology, 2004
Background Published work suggests that some types of endothelial cells undergo apoptosis in response to ligation of the receptor Fas (CD95, APO1) but other types are resistant.
Wang Rongqi, Dincer Erhan, Gidea Claudia, Ang Edmund, Filippatos Gerasimos, Uhal Bruce D   +5 more
doaj   +1 more source

Receptor interacting protein-2 plays a critical role in human lung epithelial cells survival in response to Fas-induced cell-death. [PDF]

PLoS ONE, 2014
Lung epithelial cell death is critical to the lung injury that occurs in the acute respiratory distress syndrome. It is known that FasL plays a prominent role in this lung cell death pathway and may work in part through activation of the receptor ...
Mohd Akhlakur Rahman, Kruthika Sundaram, Srabani Mitra, Mikhail A Gavrilin, Mark D Wewers   +4 more
doaj   +1 more source

Display of Fas Ligand Protein on Cardiac Vasculature as a Novel Means of Regulating Allograft Rejection [PDF]

Circulation, 2003
Background— Fas ligand (FasL) is a potent death-inducing molecule with important functions in immune homeostasis and tolerance to self-antigens. The complex biological activities of FasL and its inefficient expression using conventional gene transfer approaches limit its use for immunomodulation to ...
Nadir, Askenasy, Esma S, Yolcu, Zhiliang, Wang, Haval, Shirwan   +3 more
openaire   +2 more sources