Results 31 to 40 of about 100,182 (262)

Bistability in apoptosis by receptor clustering. [PDF]

PLoS Computational Biology, 2010
Apoptosis is a highly regulated cell death mechanism involved in many physiological processes. A key component of extrinsically activated apoptosis is the death receptor Fas which, on binding to its cognate ligand FasL, oligomerize to form the death ...
Kenneth L Ho, Heather A Harrington
doaj   +1 more source

Engineering adoptive T cell therapy to co-opt Fas ligand-mediated death signaling in ovarian cancer enhances therapeutic efficacy

Journal for ImmunoTherapy of Cancer, 2022
Background In the USA, more than 50% of patients with ovarian cancer die within 5 years of diagnosis, highlighting the need for therapeutic innovations.
Philip D Greenberg, Kristin G Anderson, Shannon K Oda, Breanna M Bates, Madison G Burnett, Magdalia Rodgers Suarez, Susan L Ruskin   +6 more
doaj   +1 more source

Nutrient-dependent phosphorylation channels lipid synthesis to regulate PPARα

Journal of Lipid Research, 2013
Peroxisome proliferator-activated receptor (PPAR)α is a nuclear receptor that coordinates liver metabolism during fasting. Fatty acid synthase (FAS) is an enzyme that stores excess calories as fat during feeding, but it also activates hepatic PPARα by ...
Anne P.L. Jensen-Urstad, Haowei Song, Irfan J. Lodhi, Katsuhiko Funai, Li Yin, Trey Coleman, Clay F. Semenkovich   +6 more
doaj   +1 more source

Fas/CD95 prevents autoimmunity independently of lipid raft localization and efficient apoptosis induction

Nature Communications, 2016
Fas drives apoptosis and mutations in this receptor can cause autoimmunity through failure of cell death. Here, the authors uselpr/lprmice with palmitoylation-defective mutant Fas to provide evidence that Fas might limit spontaneous autoimmunity through ...
Anthony C. Cruz, Madhu Ramaswamy, Claudia Ouyang, Christopher A. Klebanoff, Prabuddha Sengupta, Tori N. Yamamoto, Françoise Meylan, Stacy K. Thomas, Nathan Richoz, Robert Eil, Susan Price, Rafael Casellas, V. Koneti Rao, Jennifer Lippincott-Schwartz, Nicholas P. Restifo, Richard M. Siegel   +15 more
doaj   +1 more source

An examination of the Apo-1/Fas promoter Mva I polymorphism in Japanese patients with multiple sclerosis

BMC Neurology, 2002
Background The Apo-1/Fas (CD95) molecule is an apoptosis-signaling cell surface receptor belonging to the tumor necrosis factor (TNF) receptor family. Both Fas and Fas ligand (FasL) are expressed in activated mature T cells, and prolonged cell activation
Yabe Ichiro, Miyagishi Ryuji, Fukazawa Toshiyuki, Kikuchi Seiji, Niino Masaaki, Tashiro Kunio   +5 more
doaj   +1 more source

New aspects of the role of Fas receptor and Fas Ligand in patients with Sjögren’s syndrome [PDF]

, 2022
Abstract Background: Sjögren’s syndrome patients, like other patients with autoimmune disorders, display dysregulation in the function of their immune system. Fas and Fas Ligand (FasL) belong among dysregulated proteins. Although they have been long studied, there are still several unknown aspects of biological importance of Fas and FasL ...
Irena Lindrova, Martina Kolackova, Tereza Svadlakova, Radka Vankova, Marcela Chmelarova, Michaela Rosecka, Martin Sembera, Jan Krejsek, Radovan Slezak   +8 more
openaire   +1 more source

Fas and Fas Ligand are associated with neuritic degeneration in the AD brain and participate in β-amyloid-induced neuronal death

Neurobiology of Disease, 2003
It has recently been suggested that neuronal cell death in response to many brain insults may be mediated by the upregulation of tumor necrosis factor receptor (TNFR) family members and their ligands.
Joseph H Su, Aileen J Anderson, David H Cribbs, Christina Tu, Liqi Tong, Patrick Kesslack, Carl W Cotman   +6 more
doaj   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

MOAP-1 Mediates Fas-Induced Apoptosis in Liver by Facilitating tBid Recruitment to Mitochondria

Cell Reports, 2016
Fas apoptotic signaling regulates diverse physiological processes. Acute activation of Fas signaling triggers massive apoptosis in liver. Upon Fas receptor stimulation, the BH3-only protein Bid is cleaved into the active form, tBid.
Chong Teik Tan, Qi-Ling Zhou, Yu-Chin Su, Nai Yang Fu, Hao-Chun Chang, Ran N. Tao, Sunil K. Sukumaran, Shairaz Baksh, Yee-Joo Tan, Kanaga Sabapathy, Chun-Dong Yu, Victor C. Yu   +11 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source