Results 31 to 40 of about 105,192 (298)

The role of MMP7 and its cross-talk with the FAS/FASL system during the acquisition of chemoresistance to oxaliplatin. [PDF]

PLoS ONE, 2009
BACKGROUND: The efficacy of oxaliplatin in cancer chemotherapy is limited by the development of drug resistance. MMP7 has been related to the loss of tumor cell response to cytotoxic agents although the exact mechanism is not fully understood.
Vanessa Almendro, Elisabet Ametller, Susana García-Recio, Olga Collazo, Ignasi Casas, Josep M Augé, Joan Maurel, Pedro Gascón   +7 more
doaj   +1 more source

Adhesion G protein-coupled receptor VLGR1/ADGRV1 regulates cell spreading and migration by mechanosensing at focal adhesions

iScience, 2021
Summary: VLGR1 (very large G protein-coupled receptor-1) is by far the largest adhesion G protein-coupled receptor in humans. Homozygous pathologic variants of VLGR1 cause hereditary deaf blindness in Usher syndrome 2C and haploinsufficiency of VLGR1 is ...
Deva K. Kusuluri, Baran E. Güler, Barbara Knapp, Nicola Horn, Karsten Boldt, Marius Ueffing, Gabriela Aust, Uwe Wolfrum   +7 more
doaj   +1 more source

Involvement of raft aggregates enriched in Fas/CD95 death-inducing signaling complex in the antileukemic action of edelfosine in Jurkat cells. [PDF]

PLoS ONE, 2009
BACKGROUND: Recent evidence suggests that co-clustering of Fas/CD95 death receptor and lipid rafts plays a major role in death receptor-mediated apoptosis.
Consuelo Gajate, Fernando Gonzalez-Camacho, Faustino Mollinedo   +2 more
doaj   +1 more source

Decidual Macrophages Are Significantly Increased in Spontaneous Miscarriages and Over-Express FasL [PDF]

, 2012
Decidual macrophages (DM) are the second most abundant population in the fetal-maternal interface. Their role has been so far identified as being local immuno-modulators favoring the maternal tolerance to the fetus.
Iordanis Navrozoglou, Darius Dian, Antonis Makrigiannakis, Sabine Guenther, Anz, David, Jeschke, Udo, Klaus Friese, Udo Jeschke, Thomas Vrekoussis, Vrekoussis, Thomas, Knabl, Julia, Dian, Darius, Julia Knabl, Bayer, Birgit, Heublein, Sabine, Navrozoglou, Iordanis, Friese, Klaus, Sabine Heublein, Makrigiannakis, Antonis, David Anz, Guenther, Sabine, Birgit Bayer   +21 more
core   +1 more source

Tissue Inhibitor of Metalloproteinase-3 (TIMP-3) induces FAS dependent apoptosis in human vascular smooth muscle cells. [PDF]

PLoS ONE, 2018
Over expression of Tissue Inhibitor of Metalloproteinases-3 (TIMP-3) in vascular smooth muscle cells (VSMCs) induces apoptosis and reduces neointima formation occurring after saphenous vein interposition grafting or coronary stenting.
William R English, Heather Ireland-Zecchini, Andrew H Baker, Trevor D Littlewood, Martin R Bennett, Gillian Murphy   +5 more
doaj   +1 more source

An Evolution-Guided Analysis Reveals a Multi-Signaling Regulation of Fas by Tyrosine Phosphorylation and its Implication in Human Cancers.

PLoS Biology, 2016
Demonstrations of both pro-apoptotic and pro-survival abilities of Fas (TNFRSF6/CD95/APO-1) have led to a shift from the exclusive "Fas apoptosis" to "Fas multisignals" paradigm and the acceptance that Fas-related therapies face a major challenge, as it ...
Krittalak Chakrabandhu, Sébastien Huault, Jérôme Durivault, Kévin Lang, Ly Ta Ngoc, Angelique Bole, Eszter Doma, Benoit Dérijard, Jean-Pierre Gérard, Michel Pierres, Anne-Odile Hueber   +10 more
doaj   +1 more source

Bistability in apoptosis by receptor clustering. [PDF]

PLoS Computational Biology, 2010
Apoptosis is a highly regulated cell death mechanism involved in many physiological processes. A key component of extrinsically activated apoptosis is the death receptor Fas which, on binding to its cognate ligand FasL, oligomerize to form the death ...
Kenneth L Ho, Heather A Harrington
doaj   +1 more source

New aspects of the role of Fas receptor and Fas Ligand in patients with Sjögren’s syndrome [PDF]

, 2022
Abstract Background: Sjögren’s syndrome patients, like other patients with autoimmune disorders, display dysregulation in the function of their immune system. Fas and Fas Ligand (FasL) belong among dysregulated proteins. Although they have been long studied, there are still several unknown aspects of biological importance of Fas and FasL ...
Irena Lindrova, Martina Kolackova, Tereza Svadlakova, Radka Vankova, Marcela Chmelarova, Michaela Rosecka, Martin Sembera, Jan Krejsek, Radovan Slezak   +8 more
openaire   +1 more source

Microparticles from patients with metabolic syndrome induce vascular hypo-reactivity via Fas/Fas-ligand pathway in mice [PDF]

, 2011
Peer ...
Andriantsitohaina Ramaroson, Benameur, Tarek, Tarek Benameur, Olga Pechanova, Martinez, Maria Carmen, S. Faure, M. Sladkova, Pechanova Olga, Faure Sébastien, Delibegovic Mirela, Pechanova, Olga, Lucie Duluc, Delibegovic, Mirela, Agouni Abdelali, Sladkova Martina, Duluc Lucie, Martinez Maria Carmen, Pierre-Henri Ducluzeau, Martina Sladkova, L. Duluc, Georges Leftheriotis, Duluc, Lucie, Mirela Delibegovic, M.C. Martinez, M. Delibegović, P.H. Ducluzeau-Fieloux, Agouni, Abdelali, Abdelali Agouni, O. Pechanova, Benameur Tarek, Andriantsitohaina, Ramaroson, Sladkova, Martina, A. Agouni, Leftheriotis, Georges, Faure, Sebastien, Ramaroson Andriantsitohaina, Ducluzeau Pierre-Henri, R. Andriantsitohaina, G. Lefthériotis, Maria Carmen Martinez, T. Benameur, Sébastien Faure, Ducluzeau, Pierre-Henri, Leftheriotis Georges   +43 more
core   +1 more source

Engineering adoptive T cell therapy to co-opt Fas ligand-mediated death signaling in ovarian cancer enhances therapeutic efficacy

Journal for ImmunoTherapy of Cancer, 2022
Background In the USA, more than 50% of patients with ovarian cancer die within 5 years of diagnosis, highlighting the need for therapeutic innovations.
Philip D Greenberg, Kristin G Anderson, Shannon K Oda, Breanna M Bates, Madison G Burnett, Magdalia Rodgers Suarez, Susan L Ruskin   +6 more
doaj   +1 more source