Results 31 to 40 of about 185,643 (306)
Expression of Fas Receptor and Fas Ligand in Eczematous Dermatitis
Journal of Skin and Stem Cell, 2019 Background: The principal role of epidermal keratinocytes (KCs) in inducing and maintaining eczematous dermatitis has been rather neglected. Objectives: The study aimed to assess the expression of Fas receptor (FasR) and Fas ligand (FasL) in the skin of eczematous dermatitis patients to examine T-cell mediated KC apoptosis.
Hanan Rabea Nada +4 more
openaire +2 more sources
Neonatal mice lacking functional Fas death receptors are resistant to hypoxic–ischemic brain injury
Neurobiology of Disease, 2004 Neonatal hypoxia–ischemia (HI) upregulates Fas death receptor expression in the brain, and alterations in expression and activity of Fas signaling intermediates occur in neonatal brain injury. B6.MRL-Tnfrsf6lpr mice lacking functional Fas death receptors
Ernest M. Graham +6 more
doaj +1 more source
The role of MMP7 and its cross-talk with the FAS/FASL system during the acquisition of chemoresistance to oxaliplatin. [PDF]
PLoS ONE, 2009 BACKGROUND: The efficacy of oxaliplatin in cancer chemotherapy is limited by the development of drug resistance. MMP7 has been related to the loss of tumor cell response to cytotoxic agents although the exact mechanism is not fully understood.
Vanessa Almendro +7 more
doaj +1 more source
iScience, 2021 Summary: VLGR1 (very large G protein-coupled receptor-1) is by far the largest adhesion G protein-coupled receptor in humans. Homozygous pathologic variants of VLGR1 cause hereditary deaf blindness in Usher syndrome 2C and haploinsufficiency of VLGR1 is ...
Deva K. Kusuluri +7 more
doaj +1 more source
PLoS ONE, 2015 Viral double-stranded RNA (dsRNA) is recognised by pathogen recognition receptors such as Toll-Like Receptor 3 (TLR3) and retinoic acid inducible gene-I (RIG-I), and results in cytokine and interferon production. Fas, a well characterised death receptor,
Caitriona Lyons +4 more
doaj +1 more source
Involvement of raft aggregates enriched in Fas/CD95 death-inducing signaling complex in the antileukemic action of edelfosine in Jurkat cells. [PDF]
PLoS ONE, 2009 BACKGROUND: Recent evidence suggests that co-clustering of Fas/CD95 death receptor and lipid rafts plays a major role in death receptor-mediated apoptosis.
Consuelo Gajate +2 more
doaj +1 more source
Estrous cycle-dependent changes of Fas expression in the bovine corpus luteum: influence of keratin 8/18 intermediate filaments and cytokines [PDF]
, 2012 Background Fas expression and Fas-induced apoptosis are mechanisms attributed to the selective destruction of cells of the corpus luteum (CL) during luteal regression.
Birt, Alyssa +3 more
core +2 more sources
PLoS Biology, 2016 Demonstrations of both pro-apoptotic and pro-survival abilities of Fas (TNFRSF6/CD95/APO-1) have led to a shift from the exclusive "Fas apoptosis" to "Fas multisignals" paradigm and the acceptance that Fas-related therapies face a major challenge, as it ...
Krittalak Chakrabandhu +10 more
doaj +1 more source
Bistability in apoptosis by receptor clustering. [PDF]
PLoS Computational Biology, 2010 Apoptosis is a highly regulated cell death mechanism involved in many physiological processes. A key component of extrinsically activated apoptosis is the death receptor Fas which, on binding to its cognate ligand FasL, oligomerize to form the death ...
Kenneth L Ho, Heather A Harrington
doaj +1 more source
Life in the Fas lane: differential outcomes of Fas signalling [PDF]
, 2013 Fas, also known as CD95 or APO-1, is a member of the tumor necrosis factor/nerve growth factor superfamily. Although best characterized in terms of its apoptotic function, recent studies have identified several other cellular responses emanating from Fas.
Brint, Elizabeth K. +2 more
core +1 more source