Results 31 to 40 of about 1,390,716 (291)

Monocytes regulate the mechanism of T-cell death by inducing Fas-mediated apoptosis during bacterial infection. [PDF]

, 2012
Monocytes and T-cells are critical to the host response to acute bacterial infection but monocytes are primarily viewed as amplifying the inflammatory signal.
Mitchell, T.J., Timothy J. Mitchell (150478), Moira K. B. Whyte (150482), David H. Dockrell (114218), Read Robert C., Daigneault, Marc, Daigneault Marc, De Silva, T.I., Helen M. Marriott (150472), De Silva Thushan I., Marriott, Helen M, Preston, Julie A, Dockrell, David H, Marriott, H.M., Julie A Preston, Thushan I. De Silva, De Silva, Thushan I., Dockrell, David H., Whyte, M.K.B., Martin A. Bewley, Preston, Julie A., Mitchell Timothy J., Andrea M. Mitchell, Timothy J Mitchell, Whyte, Moira K B, Mitchell Andrea M., Thushan I. De Silva (150466), Moira K. B. Whyte, Preston Julie A., Helen M Marriott, Preston, J.A., Martin A. Bewley (150467), Robert C Read, Bewley, M.A., Marc Daigneault (150463), Marc Daigneault, Dockrell, D.H., Mitchell, Andrea M; id_orcid, Whyte Moira K. B., Whyte, Moira K. B., Marriott Helen M., Mitchell, Andrea M., Read, Robert C., Robert C. Read (145234), De Silva, Thushan I, Mitchell, Timothy J., Read, R.C., David H. Dockrell, Julie A. Preston (150469), Andrea M. Mitchell (150475), Mitchell, Timothy J, David H Dockrell, Moira K B Whyte, Marriott, Helen M., Mitchell, A.M., Timothy J. Mitchell, Andrea M Mitchell, Bewley, Martin A, Daigneault, M., Read, Robert C, Robert C. Read, Dockrell David H., Bewley, Martin A., Martin A Bewley, Helen M. Marriott, Julie A. Preston, Dockrell, David, Bewley Martin A., Thushan I De Silva   +68 more
core   +1 more source

Involvement of raft aggregates enriched in Fas/CD95 death-inducing signaling complex in the antileukemic action of edelfosine in Jurkat cells. [PDF]

PLoS ONE, 2009
BACKGROUND: Recent evidence suggests that co-clustering of Fas/CD95 death receptor and lipid rafts plays a major role in death receptor-mediated apoptosis.
Consuelo Gajate, Fernando Gonzalez-Camacho, Faustino Mollinedo   +2 more
doaj   +1 more source

CD95 co-stimulation blocks activation of naive T cells by inhibiting T cell receptor signaling [PDF]

, 2009
CD95 is a multifunctional receptor that induces cell death or proliferation depending on the signal, cell type, and cellular context. Here, we describe a thus far unknown function of CD95 as a silencer of T cell activation.
Lindquist, Jonathan, Strauss, Gudrun, Lindquist, Jonathan A., Arhel, Nathalie, Nathalie Arhel, Tobias L. Haas, Edward Felder, Fulda, Simone, Haas, Tobias L., Henning Walczak, Felder, Edward, Kirchhoff, Frank, Gudrun Strauss, Sabine Karl, Simone Fulda, Walczak, Henning, Karl, Sabine, Frank Kirchhoff, Klaus-Michael Debatin, Debatin, Klaus-Michael, Jonathan A. Lindquist, Haas, Tobias   +21 more
core   +1 more source

Tissue Inhibitor of Metalloproteinase-3 (TIMP-3) induces FAS dependent apoptosis in human vascular smooth muscle cells. [PDF]

PLoS ONE, 2018
Over expression of Tissue Inhibitor of Metalloproteinases-3 (TIMP-3) in vascular smooth muscle cells (VSMCs) induces apoptosis and reduces neointima formation occurring after saphenous vein interposition grafting or coronary stenting.
William R English, Heather Ireland-Zecchini, Andrew H Baker, Trevor D Littlewood, Martin R Bennett, Gillian Murphy   +5 more
doaj   +1 more source

An Evolution-Guided Analysis Reveals a Multi-Signaling Regulation of Fas by Tyrosine Phosphorylation and its Implication in Human Cancers.

PLoS Biology, 2016
Demonstrations of both pro-apoptotic and pro-survival abilities of Fas (TNFRSF6/CD95/APO-1) have led to a shift from the exclusive "Fas apoptosis" to "Fas multisignals" paradigm and the acceptance that Fas-related therapies face a major challenge, as it ...
Krittalak Chakrabandhu, Sébastien Huault, Jérôme Durivault, Kévin Lang, Ly Ta Ngoc, Angelique Bole, Eszter Doma, Benoit Dérijard, Jean-Pierre Gérard, Michel Pierres, Anne-Odile Hueber   +10 more
doaj   +1 more source

Extracorporeal immune therapy with immobilized agonistic anti-Fas antibodies leads to transient reduction of circulating neutrophil numbers and limits tissue damage after hemorrhagic shock/resuscitation in a porcine model [PDF]

, 2010
Background: Hemorrhagic shock/resuscitation is associated with aberrant neutrophil activation and organ failure. This experimental porcine study was done to evaluate the effects of Fas-directed extracorporeal immune therapy with a leukocyte inhibition ...
Sarah Sadek, Altrichter, Jens, José Bitu-Moreno, Windolf Joachim, Scholz Martin, Ott Annina, Sadek Sarah, Teresa Jeri, Adnana Paunel-Görgülü, Martin Sager, Baltes Jessica, Müller, Wolfram, Sager, Martin, Witte Ingo, Ingo Witte, Jens Altrichter, Martin Scholz, Sager Martin, Sadek, Sarah, Schek, Alberto, Bitu-Moreno José, Windolf, Joachim, Lögters, Tim Tobias, Witte, Ingo, Bitu-Moreno, José, Jeri, Teresa, Altrichter Jens, Paunel-Görgülü Adnana, Jeri Teresa, Joachim Windolf, Alberto Schek, Baltes, Jessica, Wolfram Müller, Annina Ott, Müller Wolfram, Schek Alberto, Scholz, Martin, Jessica Baltes, Ott, Annina, Tim T Lögters, Paunel-Görgülü, Adnana-Nicoleta, Lögters Tim T   +41 more
core   +1 more source

Bistability in apoptosis by receptor clustering. [PDF]

PLoS Computational Biology, 2010
Apoptosis is a highly regulated cell death mechanism involved in many physiological processes. A key component of extrinsically activated apoptosis is the death receptor Fas which, on binding to its cognate ligand FasL, oligomerize to form the death ...
Kenneth L Ho, Heather A Harrington
doaj   +1 more source

New aspects of the role of Fas receptor and Fas Ligand in patients with Sjögren’s syndrome [PDF]

, 2022
Abstract Background: Sjögren’s syndrome patients, like other patients with autoimmune disorders, display dysregulation in the function of their immune system. Fas and Fas Ligand (FasL) belong among dysregulated proteins. Although they have been long studied, there are still several unknown aspects of biological importance of Fas and FasL ...
Irena Lindrova, Martina Kolackova, Tereza Svadlakova, Radka Vankova, Marcela Chmelarova, Michaela Rosecka, Martin Sembera, Jan Krejsek, Radovan Slezak   +8 more
openaire   +1 more source

Engineering adoptive T cell therapy to co-opt Fas ligand-mediated death signaling in ovarian cancer enhances therapeutic efficacy

Journal for ImmunoTherapy of Cancer, 2022
Background In the USA, more than 50% of patients with ovarian cancer die within 5 years of diagnosis, highlighting the need for therapeutic innovations.
Philip D Greenberg, Kristin G Anderson, Shannon K Oda, Breanna M Bates, Madison G Burnett, Magdalia Rodgers Suarez, Susan L Ruskin   +6 more
doaj   +1 more source

Bid participates in genotoxic drug-induced apoptosis of HeLa cells and is essential for death receptor ligands' apoptotic and synergistic effects [PDF]

, 2008
Background: The BH3-only protein Bid is an important component of death receptor-mediated caspase activation. Bid is cleaved by caspase-8 or -10 into t-Bid, which translocates to mitochondria and triggers the release of caspase-activating factors.
Caoimhin G Concannon, Anguissola, Sergio, Barbara Köhler, Jochen H M Prehn, Markus Rehm (7899308), Kögel, Donat, Barbara Köhler (60110), Caoimhín G. Concannon (7953038), Donat Kögel, Sergio Anguissola, Prehn, Jochen H. M., Donat Kögel (60113), Köhler, Barbara, Rehm, Markus, Sergio Anguissola (60111), Jochen Prehn (7895672), Concannon, Caoimhin G., Markus Rehm   +17 more
core   +1 more source