FAS-dependent cell death in α-synuclein transgenic oligodendrocyte models of multiple system atrophy. [PDF]
PLoS ONE, 2013 Multiple system atrophy is a parkinsonian neurodegenerative disorder. It is cytopathologically characterized by accumulation of the protein p25α in cell bodies of oligodendrocytes followed by accumulation of aggregated α-synuclein in so-called glial ...
Christine L Kragh +12 more
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Fas death receptor signalling: roles of Bid and XIAP [PDF]
Cell Death & Differentiation, 2011 Fas (also called CD95 or APO-1), a member of a subgroup of the tumour necrosis factor receptor superfamily that contain an intracellular death domain, can initiate apoptosis signalling and has a critical role in the regulation of the immune system. Fas-induced apoptosis requires recruitment and activation of the initiator caspase, caspase-8 (in humans ...
Kaufmann T, Strasser A, Jost P J
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Engagement of Fas on Macrophages Modulates Poly I:C induced cytokine production with specific enhancement of IP-10. [PDF]
PLoS ONE, 2015 Viral double-stranded RNA (dsRNA) is recognised by pathogen recognition receptors such as Toll-Like Receptor 3 (TLR3) and retinoic acid inducible gene-I (RIG-I), and results in cytokine and interferon production. Fas, a well characterised death receptor,
Caitriona Lyons +4 more
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Dermatology - Open Journal, 2016 The FAS receptor (FasR), also known as apoptosis antigen 1 (APO-1 or APT), cluster of differentiation95 (CD95) or tumor necrosis factor receptor superfamily 6 (TNFRSF6) is a proteinthat in humans is encoded by the FAS gene.
Hanan Rabea Nada
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The role of soluble FMS-like tyrosine kinase (sFLT1) and FAS associated proteins in pregnancies complicated by preeclampsia and intrauterine growth restriction (IUGR). [PDF]
, 2005 PhDCurrent thinking suggests that preeclampsia is associated with activation of the maternal vascular endothelium in response to factors released from the placenta due to placental hypoxia.
Fayyad, Abdalla Mustafa
core +4 more sources
Functional characterization of a chimeric soluble Fas ligand polymer with in vivo anti-tumor activity. [PDF]
PLoS ONE, 2013 Binding of ligand FasL to its receptor Fas triggers apoptosis via the caspase cascade. FasL itself is homotrimeric, and a productive apoptotic signal requires that FasL be oligomerized beyond the homotrimeric state. We generated a series of FasL chimeras
Sophie Daburon +13 more
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Pro- and anti-apoptotic fate decisions induced by di- and trimeric synthetic cytokine receptors
iScience, 2021 Summary: Synthetic strategies to activate cytokine receptors so far only address standard dimeric cytokine receptor assemblies. The 19 ligands of the tumor necrosis factor superfamily (TNFSF), however, form noncovalent trimers and receptor trimerization ...
Sofie Mossner +2 more
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Requirement of Cysteine-rich Repeats of the Fas Receptor for Binding by the Fas Ligand [PDF]
Journal of Biological Chemistry, 1997 The Fas receptor is a member of a family of cell death receptors, including tumor necrosis factor receptor I (TNFR I), death receptor 3 and 4 (DR3 and DR4), and cytopathic avian receptor 1 (CAR1). The Fas receptor is composed of several discrete domains, including three cysteine-rich domains (CRDs), a transmembrane domain, and an intracellular domain ...
J R, Orlinick +3 more
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The FAS-receptors of apoptosis expression on the medulloblastomas cells
Ukrainian Neurosurgical Journal, 2005 The Fas-receptor of apoptosis expression on the living medulloblastomas cells was determined. Fas-receptor of apoptosis was expressed on 4–48,8% tumors cells.
Yu. A. Orlov +5 more
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A comparison of the cytoplasmic domains of the Fas receptor and the p75 neurotrophin receptor [PDF]
Cell Death & Differentiation, 1999 The p75 neurotrophic receptor (p75) shares structural features with the Fas receptor (FasR). Both receptors contain extracellular cysteine-rich repeats, a single transmembrane domain, and intracellular death domains. However, it has not been clearly established whether their death domains are equivalent in their ability to mediate apoptosis.
H, Kong +3 more
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