Results 11 to 20 of about 100,182 (262)

Functional characterization of a chimeric soluble Fas ligand polymer with in vivo anti-tumor activity. [PDF]

PLoS ONE, 2013
Binding of ligand FasL to its receptor Fas triggers apoptosis via the caspase cascade. FasL itself is homotrimeric, and a productive apoptotic signal requires that FasL be oligomerized beyond the homotrimeric state. We generated a series of FasL chimeras
Sophie Daburon, Christel Devaud, Pierre Costet, Aurore Morello, Laure Garrigue-Antar, Mike Maillasson, Nathalie Hargous, Delphine Lapaillerie, Marc Bonneu, Julie Dechanet-Merville, Patrick Legembre, Myriam Capone, Jean-François Moreau, Jean-Luc Taupin   +13 more
doaj   +1 more source

Pro- and anti-apoptotic fate decisions induced by di- and trimeric synthetic cytokine receptors

iScience, 2021
Summary: Synthetic strategies to activate cytokine receptors so far only address standard dimeric cytokine receptor assemblies. The 19 ligands of the tumor necrosis factor superfamily (TNFSF), however, form noncovalent trimers and receptor trimerization ...
Sofie Mossner, Doreen Manuela Floss, Jürgen Scheller   +2 more
doaj   +1 more source

Requirement of Cysteine-rich Repeats of the Fas Receptor for Binding by the Fas Ligand [PDF]

Journal of Biological Chemistry, 1997
The Fas receptor is a member of a family of cell death receptors, including tumor necrosis factor receptor I (TNFR I), death receptor 3 and 4 (DR3 and DR4), and cytopathic avian receptor 1 (CAR1). The Fas receptor is composed of several discrete domains, including three cysteine-rich domains (CRDs), a transmembrane domain, and an intracellular domain ...
J R, Orlinick, A, Vaishnaw, K B, Elkon, M V, Chao   +3 more
openaire   +2 more sources

The FAS-receptors of apoptosis expression on the medulloblastomas cells

Ukrainian Neurosurgical Journal, 2005
The Fas-receptor of apoptosis expression on the living medulloblastomas cells was determined. Fas-receptor of apoptosis was expressed on 4–48,8% tumors cells.
Yu. A. Orlov, A. N. Lisyany, A. V. Shaversky, T. A. Malysheva, O. G. Chernenko, L. I. Primushko   +5 more
doaj   +1 more source

A comparison of the cytoplasmic domains of the Fas receptor and the p75 neurotrophin receptor [PDF]

Cell Death & Differentiation, 1999
The p75 neurotrophic receptor (p75) shares structural features with the Fas receptor (FasR). Both receptors contain extracellular cysteine-rich repeats, a single transmembrane domain, and intracellular death domains. However, it has not been clearly established whether their death domains are equivalent in their ability to mediate apoptosis.
H, Kong, A H, Kim, J R, Orlinick, M V, Chao   +3 more
openaire   +2 more sources

Fas (CD95) induces rapid, TLR4/IRAK4-dependent release of pro-inflammatory HMGB1 from macrophages

Journal of Inflammation, 2010
Although Fas (CD95) is recognized as a death receptor that induces apoptosis, recent studies indicate that the Fas/FasL system can induce pro-inflammatory cytokine production by macrophages independent of conventional caspase-mediated apoptotic signaling.
Kain Kevin C, Yang Huan, Hawkes Michael, Lu Ziyue, Wang Feng, Liles W Conrad   +5 more
doaj   +1 more source

Necrotic Death Pathway in FAS Receptor Signaling [PDF]

The Journal of Cell Biology, 2000
A caspase 8–deficient subline (JB6) of human Jurkat cells can be killed by the oligomerization of Fas-associated protein with death domain (FADD). This cell death process is not accompanied by caspase activation, but by necrotic morphological changes.
H, Matsumura, Y, Shimizu, Y, Ohsawa, A, Kawahara, Y, Uchiyama, S, Nagata   +5 more
openaire   +2 more sources

Coordinated control of bile acids and lipogenesis through FXR-dependent regulation of fatty acid synthase1

Journal of Lipid Research, 2006
We discovered a nuclear receptor element in the FAS promoter consisting of an inverted repeat spaced by one nucleotide (IR-1) and located 21 bases downstream of a direct repeat sequenced by 4 nucleotides (DR-4) oxysterol liver X receptor response element.
Karen E. Matsukuma, Mary K. Bennett, Jiansheng Huang, Li Wang, Gregorio Gil, Timothy F. Osborne   +5 more
doaj   +1 more source

Expression of TRAIL and Fas in Primary Hyperparathyroidism

Journal of Investigative Surgery, 2017
Aim: Differentiating between parathyroid lesions is still difficult and ambiguous. In cases of primary hyperparathyroidism, appropriate and prompt diagnosis is of great importance for effective treatment and follow-up.
Oliwia Anna Segiet, Mariusz Deska, Łukasz Mielańczyk, Marlena Brzozowa-Zasada, Grzegorz Buła, Jacek Gawrychowski, Romuald Wojnicz   +6 more
doaj   +1 more source

Molecular dynamics simulation of Fe-NO2 At-alpha mangostin as radiopharmaceutical model for detection of fatty acid synthase in cancer

Journal of Advanced Pharmaceutical Technology & Research, 2021
α-mangostin is a xanthone compound isolated from mangosteen pericarp. It is known as an anticancer through induction of apoptotic process by inhibiting fatty acid synthase (FAS) receptor. α-mangostin is a potentially useful ligand for diagnostic purposes
N Elly Rosilawati, Muhamad Yusuf, Achmad Hussein S. Kartamihardja, Shaharum Samsuddin, Muchtaridi Muchtaridi   +4 more
doaj   +1 more source