Human FasL gene is a target of β-catenin/T-cell factor pathway and complex FasL haplotypes alter promoter functions. [PDF]
PLoS ONE, 2011 FasL expression on human immune cells and cancer cells plays important roles in immune homeostasis and in cancer development. Our previous study suggests that polymorphisms in the FasL promoter can significantly affect the gene expression in human cells.
Jianming Wu +9 more
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ZNRF1 deficiency disrupts Fas ligand trafficking and immune balance [PDF]
Cell Death and DiseaseFas ligand (FasL)-mediated apoptosis constrains immune responses by eliminating activated lymphocytes, yet how FasL is delivered to the plasma membrane in myeloid cells remains unclear.
Ting-Yu Lai +8 more
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Fas/FasL Contributes to HSV-1 Brain Infection and Neuroinflammation
Frontiers in Immunology, 2021 The Fas/FasL pathway plays a key role in immune homeostasis and immune surveillance. In the central nervous system (CNS) Fas/FasL is involved in axonal outgrowth and adult neurogenesis.
Malgorzata Krzyzowska +6 more
doaj +2 more sources
HeliyonBackground: The initiator of cytokine storm in Coronavirus disease (COVID-19) is still unknown. We recently suggested a complex interaction of matrix metalloproteinases (MMPs), Fas ligand (FasL), and viral entry factors could be responsible for the ...
Abbas Azadmehr +2 more
exaly +3 more sources
Expression changes in Fasl-deficient calvaria-derived osteoblasts: an RNA-seq analysis [PDF]
Scientific DataFasl-deficient (gld) mice display an altered bone phenotype, but the underlying molecular mechanisms remain incompletely understood. Here we evaluated the role of FASL in the gene expression profile of osteogenic cells.
Adela Kratochvilova +5 more
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Effect of incremental interval training on levels of Fasl protein in lung tissue of mature male Wistar rats: Does exercise training reduce lung inflammation? [PDF]
Journal of Exercise & Organ Cross Talk, 2023 Intense exercise training is associated with Lung inflammation. Fasl protein on the cell surface is responsible for the initiation of the inflammatory response that finally leads to cell death at the site of inflammation, and can be interpreted as Fasl ...
Sajad Ahmadi, Reza Sheikh
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Revue Internationale Animation, Territoires et Pratiques Socioculturelles, 2021 Fondée sur la psychologie socioculturelle et sur l’articulation autour des notions de sens et de signification, l’étude, l’étude investigue les pratiques du Centre socioculturel de Prélaz-Valency à Lausanne (Suisse) en regard de la participation des ...
Franco De Guglielmo
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Fas and Fas ligand are highly expressed in lymphocytes from cervical intraepithelial neoplasia and cervical cancer patients: A possible role for immune escaping [PDF]
Iranian Journal of Basic Medical Sciences, 2022 Objective(s): Infection with high-risk human papillomavirus is required to develop cervical cancer. Some viruses modulate the Fas/FasL signaling to evade the immune response; the role of these molecules in cervical cancer is not clear.
Carla O Contreras-Ochoa +7 more
doaj +1 more source
Type-I interferon is critical for FasL expression on lung cells to determine the severity of influenza. [PDF]
PLoS ONE, 2013 Infection of influenza A virus in mammals induces hyper lung pneumonia, which often causes lethal diseases. FasL is a specific ligand of Fas, which is a type-I transmembrane protein to induce cell death.
Daisuke Fujikura +8 more
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Functional characterization of a chimeric soluble Fas ligand polymer with in vivo anti-tumor activity. [PDF]
PLoS ONE, 2013 Binding of ligand FasL to its receptor Fas triggers apoptosis via the caspase cascade. FasL itself is homotrimeric, and a productive apoptotic signal requires that FasL be oligomerized beyond the homotrimeric state. We generated a series of FasL chimeras
Sophie Daburon +13 more
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