Results 41 to 50 of about 35,096 (229)

miRNA-19a exerts an anti-apoptotic effect in spinal cord injured rats via the PTEN pathway

Archives of Medical Science, 2019
Introduction Contusion spinal cord injury is involved in a number of cellular, biochemical and molecular changes. We studied the overall expression pattern of miRNAs on day 1 and 3 after spinal cord injury and the involved pathways.
Lu Chen, Xing Li, Jianping Zhu, Binwu Xu, Yurong Gu   +4 more
doaj   +1 more source

JAK-STAT-mediated chronic inflammation impairs cytotoxic T lymphocyte activation to decrease anti-PD-1 immunotherapy efficacy in pancreatic cancer

OncoImmunology, 2017
Human pancreatic cancer does not respond to immune check point blockade immunotherapy. One key feature of pancreatic cancer is the association between its progression and chronic inflammation.
Chunwan Lu, Asif Talukder, Natasha M. Savage, Nagendra Singh, Kebin Liu   +4 more
doaj   +1 more source

CHARACTERISTICS OF SIGNALING PATHWAYS MEDIATING A CYTOTOXIC EFFECT OF DENDRITIC CELLS UPON ACTIVATED Т LYMPHOCYTES AND NK CELLS

Медицинская иммунология, 2014
. Cytotoxic/pro-apoptogenic effects of IFNα-induced dendritic cells (IFN-DCs) directed against Т-lymphocytes and NK cells were investigated in healthy donors.
T. V. Tyrinova, O. Yu. Leplina, M. A. Tikhonova, L. V. Sakhno, A. A. Ostanin, E. R. Chernykh   +5 more
doaj   +1 more source

Porcine kidney xenotransplantation: From primate models to clinical reality

Animal Models and Experimental Medicine, EarlyView.
In the face of a critical shortage of human donor kidneys for end‐stage renal disease patients, porcine kidney xenotransplantation has emerged as a viable solution. This field has navigated major hurdles, including immune rejection, physiological incompatibilities, potential biomechanical differences and the risk of cross‐species infection. To overcome
Zihang Guo, Ling Zhang, Shoulong Deng, Chuan Qin   +3 more
wiley   +1 more source

Differential expression of Fas receptors (CD95) and Fas ligands (CD95L) in HIV infected and exposed uninfected children in Cameroon versus unexposed children

The Pan African Medical Journal, 2019
INTRODUCTION: The number of HIV exposed uninfected (HEU) infants is increasing as vertical transmission is reducing. This subpopulation requires more investigations.
Béatrice Dambaya, Céline Nguefeu Nkenfou, Georgia Ambada, George Mondinde Ikomey, Linda Mekue Mouafo, Nicole Ngoufack, Elvis Ndukong Ndzi, Georges Této, Aubin Nanfack, Nelson Sonela, Joseph Fokam, Njiokou Flobert, Vittorio Colizzi, Alexis Ndjolo   +13 more
doaj   +1 more source

FasL and cytochrome c-induced apoptosis in cardiac tissue of hypertensive rats treated with Rhodomyrtus tomentosa [PDF]

Journal of Pharmacy & Pharmacognosy Research
Context: Hypertensive heart disease is a leading cause of cardiovascular mortality worldwide. Cardiomyocyte apoptosis, mediated through intrinsic (cytochrome c) and extrinsic (Fas ligand, FasL) pathways, plays a critical role in the progression of ...
Putri C. Situmorang, Masitta Tanjung, Rony A. Syahputra, Alexander P. Nugraha, Anisa Lutfia   +4 more
doaj   +1 more source

Stem cell–based therapies for type 1 diabetes: Progress in differentiation, clinical translation, and immune protection

Animal Models and Experimental Medicine, EarlyView.
Directed differentiation of pluripotent stem cells into functional pancreatic β cells have emerged as a promising strategy for the radical treatment of type 1 diabetes, with preclinical and early clinical evidence demonstrating reversal of hyperglycemia and insulin independence.
Zifan Li, Yu Kang, Yuyu Niu
wiley   +1 more source

The extracellular domains of FasL and Fas are sufficient for the formation of supramolecular FasL-Fas clusters of high stability [PDF]

The Journal of Cell Biology, 2005
Using fluorescent variants of Fas and FasL, we show that membrane FasL and Fas form supramolecular clusters that are of flexible shape, but nevertheless stable and persistent. Membrane FasL-induced Fas clusters were formed in caspase-8– or FADD-deficient cells or when a cytoplasmic deletion mutant of Fas was used suggesting that cluster formation is ...
Henkler, Frank, Behrle, Eva, Dennehy, Kevin M., Wicovsky, Andreas, Peters, Nathalie, Warnke, Clemens, Pfizenmaier, Klaus, Wajant, Harald   +7 more
openaire   +2 more sources

Toxicology and Pharmacokinetic Studies in Mice and Nonhuman Primates of the Nontoxic, Efficient, Targeted Hexameric FasL: CTLA4-FasL [PDF]

Molecular Cancer Therapeutics, 2020
Abstract Cytotoxic T-lymphocyte antigen 4 (CTLA4)-FasL, a homo-hexameric signal converter protein, is capable of inducing robust apoptosis in malignant cells of the B-cell lineage expressing its cognate B7 and Fas targets, while sparing nonmalignant ones.
Efi, Makdasi, Shira, Amsili, Alexandra, Aronin, Tatyana B, Prigozhina, Kobi, Tzdaka, Yosi Meir, Gozlan, Liat, Ben Gigi-Tamir, Jitka Yehudith, Sagiv, Fanny, Shkedy, Noam, Shani, Mark L, Tykocinski, Michal, Dranitzki Elhalel   +11 more
openaire   +2 more sources

Nuclear factor of activated T cells as a driver of tumor progression and a target for precision therapy

Animal Models and Experimental Medicine, EarlyView.
Overview illustration of dysregulated NFAT activation coordinating upstream signaling, post‐translational regulation and cancer promoting pathways to induce abnormal gene expression that drives tumor development, progression and immune escape. Abstract The Nuclear Factor of Activated T Cells (NFAT) family comprises closely related transcription factors.
Hira Khan, Khushbakhat Alia, Yusra Al Dhaheri, Muhammad Naseem, Rabah Iratni, Edgar Serfling, Khalid Muhammad   +6 more
wiley   +1 more source