Results 41 to 50 of about 37,208 (191)
The Pan African Medical Journal, 2019 INTRODUCTION: The number of HIV exposed uninfected (HEU) infants is increasing as vertical transmission is reducing. This subpopulation requires more investigations.
Béatrice Dambaya +13 more
doaj +1 more source
FasL and cytochrome c-induced apoptosis in cardiac tissue of hypertensive rats treated with Rhodomyrtus tomentosa [PDF]
Journal of Pharmacy & Pharmacognosy ResearchContext: Hypertensive heart disease is a leading cause of cardiovascular mortality worldwide. Cardiomyocyte apoptosis, mediated through intrinsic (cytochrome c) and extrinsic (Fas ligand, FasL) pathways, plays a critical role in the progression of ...
Putri C. Situmorang +4 more
doaj +1 more source
Advanced Science, EarlyView.Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang +6 more
wiley +1 more source
Production of Transgenic Cloned Miniature Pigs with Membrane-bound Human Fas Ligand (FasL) by Somatic Cell Nuclear Transfer [PDF]
, 2010 Cell-mediated xenograft rejection, including NK cells and CD8+ CTL, is a major obstacle in successful pig-to-human xenotransplantation. Human CD8+ CTL and NK cells display high cytotoxicity for pig cells, mediated at least in part by the Fas/FasL pathway.
Kwang Wook Park +9 more
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Fas-FasL in Hashimoto's thyroiditis [PDF]
, 2001 Hashimoto's thyroiditis is a common chronic autoimmune disease characterized by the loss of thyroid follicular cells (thyrocytes) that are gradually replaced by lymphocytic infiltration and diffuse fibrosis.
De Maria, R
core +1 more source
Advanced Science, EarlyView.Antigenic peptides Aβ42 and E7 self‐assemble into nanofibrils; APTES and TEOS induce SiO2 NP formation on these fibrils to form SiO2@fibril nanovaccines, which activate BMDCs in vitro. In vivo, SiO2@Aβ42 fibril nanovaccines alleviate AD symptoms and clear Aβ42 plaques in APP/PS1 mice, and SiO2@E7 fibril nanovaccines inhibit tumor growth and promote ...
Xuecheng Yang +6 more
wiley +1 more source
Neoplasia: An International Journal for Oncology Research, 2007 The capacity of FasL molecules expressed on melanoma cells to induce lymphocyte apoptosis contributes to either antitumor immune response or escape depending on their expression level.
Guillaume Sarrabayrouse +4 more
doaj +1 more source
Advanced Science, EarlyView.Single‐cell, spatial, molecular, and pathology analyses identify a CDH3‐associated malignant epithelial state in thymic epithelial tumors. This state links stem‐like and EMT programs to M2 macrophage–rich immunosuppressive niches, genomic instability, poor survival, and drug vulnerability.
Yuntao Feng +13 more
wiley +1 more source
RGD-FasL Induces Apoptosis in Hepatocellular Carcinoma [PDF]
, 2009 Natural Science Foundation of Fujian Province [C0710046]Despite impressive results obtained in animal models, the clinical use of Fas ligand (FasL) as an anticancer drug is limited by severe toxicity.
Zhang, Jiakai +34 more
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Apoptosis and Fas/FasL Pathway: role of FAS and FASL Functional Polymorphisms in Prostate Cancer development [PDF]
, 2011 Mestrado em Medicina e Oncologia MolecularMaster Degree Course in Molecular and Oncology MedicineO sistema Fas/FasL é uma das vias de apoptose mais importantes, sendo essencial na regulação da proliferação celular e do crescimento tumoral.
Lima, Luís Carlos Oliveira
core +1 more source