Results 61 to 70 of about 30,088 (148)

Understanding extracellular vesicle biology, isolation, and characterization: The theory of EV‐erything

Periodontology 2000, EarlyView.
Abstract Background Extracellular vesicles (EVs), especially exosomes, are nanoparticles increasingly recognized as key regulators of intercellular communication in both physiological and pathological aspects. Despite rapid progress, inconsistencies in nomenclature, isolation, and characterization continue to restrict translational advancement.
Paras Ahmad, Nima Farshidfar, Nathan E. Estrin, Yulan Wang, Yufeng Zhang, Anton Sculean, Richard J. Miron   +6 more
wiley   +1 more source

The In Situ Hybridization Expression of Fas and Fas Ligand (FasL) in Trophoblastic tissue of Aborted Women Compared with Normal Pregnancy.

مجلة كلية الطب, 2009
Background: Estimation of the in situ expression of Fas and Fas ligand (FasL) in aborted women compared with normal human pregnancy . Patients and Methods: A technique utilizing in situ hybridization(ISH) was performed to detect and determine the in situ
Amal H. Salman, Dalya B. Hana, Dhamraa W. Ahmad   +2 more
doaj   +1 more source

A Crazy Idea: Ibn Sīnā on Hylomorphism, the Elements, Mixture and Evolutionary Processes

Theoria, EarlyView.
ABSTRACT Ibn Sīnā (c. 973‐1037), the Avicenna of Latin fame, developed a unique theory of the elements and their status in mixtures that severely challenged the views of earlier natural philosophers and in its turn was severely challenged by later Latin Schoolmen in the West.
Jon McGinnis
wiley   +1 more source

Advancing Type 1 Diabetes Treatment: 3 PM‐Oriented Innovations in Islet Transplantation and Biomaterial Engineering

Diabetes/Metabolism Research and Reviews, Volume 42, Issue 6, September 2026.
ABSTRACT Type 1 Diabetes (T1D) is an autoimmune disorder marked by the immune‐mediated destruction of pancreatic β‐cells, resulting in insulin deficiency and dysregulated glucose control. Current therapies—such as insulin replacement and artificial pancreas systems—manage symptoms but fail to restore endogenous β‐cell function or halt disease ...
Fatemeh Sabet Sarvestani, Ramin Yaghobi, Mohsen Khosravi Maharlooei, Mehdi Golshan, Mohammad Hossein Karimi   +4 more
wiley   +1 more source

The role of Fas ligand protein in the oxidative stress induced by azoxymethane on crypt colon of rats O papel da proteína ligante Fas no estresse oxidativo induzido pelo azoximetano em criptas do colo de ratos

Acta Cirúrgica Brasileira, 2010
PURPOSE: To study the protein Fas ligand (FasL) on the expression of apoptosis, using a model of oxidative stress induced by azoxymethane (AOM), in the crypt of colon in rats.
Luiz Antonio Maksoud Bussuan, Djalma José Fagundes, Guido Marks, Priscila Maksoud Bussuan, Roberto Teruya   +4 more
doaj   +1 more source

MicroRNAs in Spinal Cord Injury: Molecular and Translational Insights

Brain and Behavior, Volume 16, Issue 8, August 2026.
MicroRNAs (miRNAs) modulate secondary injury cascades following spinal cord injury (SCI), including inflammation, oxidative stress, apoptosis, and demyelination. Key miRNAs such as miR‐21, miR‐124, miR‐219, and miR‐223 exert neuroprotective effects by regulating astrocytic response, axon regeneration, and remyelination.
Seyyedeh Fahimeh Talebi, Hossein Kalarestaghi, Ehsan Sheikh Hesabi, Saeed Vafaei‐Nezhad   +3 more
wiley   +1 more source

Circulating Apoptotic Signals During Acute and Chronic Exposure to High Altitude in Kyrgyz Population

Frontiers in Physiology, 2019
Background: Circulating apoptotic signals (CASs) have been described in the pathologies associated with dysregulated apoptosis, such as cancer, heart diseases, and pulmonary hypertension (PH).
Djuro Kosanovic, Djuro Kosanovic, Simon Maximilian Platzek, Aleksandar Petrovic, Akylbek Sydykov, Abdirashit Maripov, Argen Mamazhakypov, Meerim Sartmyrzaeva, Kubatbek Muratali Uulu, Meerim Cholponbaeva, Aidana Toktosunova, Nazgul Omurzakova, Melis Duishobaev, Christina Vroom, Oleg Pak, Norbert Weissmann, Hossein Ardeschir Ghofrani, Akpay Sarybaev, Ralph Theo Schermuly   +18 more
doaj   +1 more source

Innate Immune Cells in Non‐Small Cell Lung Cancer: Roles in Tumor Progression and Therapeutic Responses

Cancer Innovation, Volume 5, Issue 4, August 2026.
Innate immune cells (IICs) are not only as first‐line defenders or simple auxiliaries to adaptive immunity, but also as decisive regulators of non‐small cell lung cancer progression and treatment outcomes. ABSTRACT As a leading cause of cancer‐related morbidity and mortality worldwide, non‐small cell lung cancer (NSCLC) is profoundly influenced by ...
Jiaxin Liu, Jie Jia, Chong Wang, Zongru Zhou, Zhuoyu Cheng, Ziyi Zhang, Xueyi Jiang, Ziyu Huang, Chunyan Li   +8 more
wiley   +1 more source

From scarring to healing: Emerging regenerative therapies for pulmonary fibrosis using MSCs and exosomes

Clinical and Translational Discovery, Volume 6, Issue 4, August 2026.
MSCs exert anti‐inflammatory, anti‐fibrotic and regenerative effects in pulmonary fibrosis. MSC‐derived exosomes reproduce many therapeutic benefits of parental MSCs. Preconditioning and genetic modification improve MSC therapeutic performance. Current preclinical and clinical evidence supports the translational potential of MSC‐based therapies ...
Hajar Nasiri, Farbod Khosravi, Fatemeh Eskandari, Tahereh Manoochehrabadi, Ali Samadikuchaksaraei, Ehsan Lotfi, Jila Majidi, Fatemeh Rafati, Zeynab Ghorbani   +8 more
wiley   +1 more source

SLC7A5 promotes colorectal cancer liver metastasis by reprogramming tryptophan metabolism through the Kyn/XANA‒AhR axis and reshaping the immune microenvironment

Clinical and Translational Medicine, Volume 16, Issue 8, August 2026.
SLC7A5‒Kyn/XANA signalling activates AhR to drive EMT and metastatsis. SLC7A5 knockdown enhances macrophage antigen presentation and reverses CD8+ T‐cell exhaustion. SLC7A5 knockdown induces antigen‐driven and IgG‐secreting B‐cell clonal expansion. Combination of SLC7A5 inhibition and anti‐PD‐1 therapy offers clinical targeting.
Yaohao Luo, Lei Li, Shanbao Li, Xinshuai Wang, Zeping He, Fangbin Song, Jun Qin, Jinyan Zhang, Junming Xu   +8 more
wiley   +1 more source