Results 61 to 70 of about 35,096 (229)

Oxidative stress increases Fas ligand expression in endothelial cells

Journal of Inflammation, 2006
Background Fas ligand (FasL) induces apoptosis in Fas-bearing target cells, such as leukocytes, and up-regulation of FasL expression on the endothelium may contribute to anti-inflammatory reactions that attenuate leukocyte extravasation during ...
Nagai Atsushi, Aoshiba Kazutetsu, Suzuki Mayumi   +2 more
doaj   +1 more source

Efficacy of targeted FasL in nasopharyngeal carcinoma

Molecular Therapy, 2003
We have successfully achieved selective gene expression in human nasopharyngeal carcinoma (NPC) by exploiting the presence of the Epstein-Barr virus (EBV), utilizing a transcriptional targeting strategy (J. H. Li et al., 2002, Cancer Res. 62: 171). Building on this platform, we have generated a novel DeltaE1 adenoviral vector mediating the expression ...
Li, Jian-Hua, Shi, Wei, Chia, Marie, Sanchez-Sweatman, Otto, Siatskas, Christopher, Huang, Dolly, Busson, Pierre, Klamut, Henry, Yeh, Wen-Chen, Richardson, Chris, O'Sullivan, Brian, Gullane, Pat, Neligan, Peter, Medin, Jeff, Liu, Fei-Fei   +14 more
openaire   +2 more sources

FasL⁺ B cells express higher levels of the IL-5 receptor than FasL

, 2013
− B cells. (A) Histograms comparing surface expression of CD125 in CD19−, CD19+FasL− and CD19+FasL+ cells. (B) Quantification of median fluorescence intensity of CD125 expression in CD19+FasL− and CD19+FasL+ B cells in replicate animals (mean ± SEM ...
David A. Fox (441429), Matthew W. Klinker (441427), Tamra J. Reed (441428), Steven K. Lundy (441430)   +3 more
core   +1 more source

Radiotherapy and Immunotherapy In Hepatocellular Carcinoma: Priming the Tumor Immune Microenvironment From Bench To Bedside

Precision Radiation Oncology, EarlyView.
The dual immunomodulatory network of radiotherapy in hepatocellular carcinoma. Radiotherapy initiates its effects by inducing immunogenic cell death and DNA double‐strand breaks. Immune Activation: Cytosolic DNA from damaged cells activates the cGAS‐STING pathway, triggering IRF3/NF‐κB‐mediated type I interferon production. This enhances dendritic cell
Zhigang Fu, Yang Zhang, Zuomin Wang, Zongjuan Li, Shisuo Du   +4 more
wiley   +1 more source

Fas Ligand DNA Enhances a Vaccination Effect by Coadministered DNA Encoding a Tumor Antigen through Augmenting Production of Antibody against the Tumor Antigen

Journal of Immunology Research, 2015
Interaction of Fas and Fas ligand (FasL) plays an important role in the regulation of immune responses by inducing apoptosis of activated cells; however, a possible role of FasL in DNA vaccination has not been well understood.
Boya Zhong, Guangyu Ma, Ayako Sato, Osamu Shimozato, Hongdan Liu, Quanhai Li, Masato Shingyoji, Yuji Tada, Koichiro Tatsumi, Hideaki Shimada, Kenzo Hiroshima, Masatoshi Tagawa   +11 more
doaj   +1 more source

Palmitoylation of human FasL modulates its cell death-inducing function.

, 2010
International audienceFas ligand (FasL) is a transmembrane protein that regulates cell death in Fas-bearing cells. FasL-mediated cell death is essential for immune system homeostasis and the elimination of viral or transformed cells.
Marguet, D., Mailfert, S., S Mailfert, F Guardiola-Serrano, N Cahuzac, Hueber, A.-O., Lückerath, K., Cahuzac, N., Melzer, I., I Melzer, D Marguet, K Lückerath, A Rossin, Guardiola-Serrano, F., Rossin, A., A-O Hueber, Zörnig, M., M Zörnig   +17 more
core   +1 more source

An Experimental Study on the Protective Effect of Memantine in Noise‐Induced Hearing Loss

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Objective This study examined the potential protective effects of memantine, an N‐methyl‐D‐aspartate (NMDA) receptor antagonist, against acoustic trauma (AT) in guinea pigs, using electrophysiological and histopathological analyses. Methods Thirty guinea pigs with normal hearing were divided into six groups (n = 5 per group): Group 1 (control),
Begüm Arda, Selis Gülseven Güven, Erdoğan Bulut, Murat Arslan, Özlem Tuğce Çilingir‐Kaya, Abdullah Taş, Recep Yağız   +6 more
wiley   +1 more source

P2X₇ signaling promotes microsphere embolism-triggered microglia activation by maintaining elevation of Fas ligand

Journal of Neuroinflammation, 2012
Background The cerebral microvascular occlusion elicits microvascular injury which mimics the different degrees of stroke severity observed in patients, but the mechanisms underlying these embolic injuries are far from understood.
Lu Ying-mei, Tao Rong-rong, Huang Ji-yun, Li Li-tao, Liao Mei-hua, Li Xiao-ming, Fukunaga Kohji, Hong Ze-Hui, Han Feng   +8 more
doaj   +1 more source

Image_3_Fas/FasL Contributes to HSV-1 Brain Infection and Neuroinflammation.jpeg

, 2021
The Fas/FasL pathway plays a key role in immune homeostasis and immune surveillance. In the central nervous system (CNS) Fas/FasL is involved in axonal outgrowth and adult neurogenesis.
Kristina Eriksson (320210), Karolina Thörn (218971), Katarzyna Skulska (11354211), Malgorzata Krzyzowska (587002), Andrzej Kowalczyk (3970700)   +4 more
core   +1 more source

Early Epidemiologic and Immune Predictors of Atopic Dermatitis: Reduced Cord Blood Regulatory B10 Cells in the Munich Atopy Prediction Study (MAPS)

Allergy, EarlyView.
In this prospective birth cohort from Munich, comprehensive clinical assessments and longitudinal lifestyle questionnaires were combined with cord blood immune profiling. Infants who later developed AD showed altered cord blood immune signatures, including reduced CD4+ T cells, increased B cells and markedly decreased Breg cells. Epidemiologic factors,
S. Preis, S. Kaesler, M. Koeberle, M. Hils, B. Evers, R. L. Silva, Y. Skabytska, L. Schellenberger, H. Hufnagel, M. Schielein, B. Kuschel, Y. Amar, A. Zink, T. Biedermann, Z. Kurgyis   +14 more
wiley   +1 more source