Results 81 to 90 of about 35,096 (229)
The Fas/FasL System in Reproduction: Survival and Apoptosis [PDF]
The Scientific World JOURNAL, 2002 For centuries, the question of “whether there is life after death” has intrigued the mind of philosophers, and the same question fascinates researchers in the field of apoptosis today. The death of a cell is by no means the end of the story. On the contrary, growing evidence suggests that the clearance of apoptotic bodies by macrophages is an important
Gil Mor +2 more
openaire +3 more sources
Biogenesis of TNF‐α‐insights into proteostasis and inflammation
The FEBS Journal, EarlyView.TNF‐α biogenesis, trafficking, and signalling are tightly and reciprocally coupled to cellular proteostasis systems, including ER chaperones and endoplasmic reticulum‐associated degradation. This bidirectional crosstalk determines whether TNF‐α responses are adaptive or proteotoxic.
Bailasan Haidar +3 more
wiley +1 more source
, 2010 Cell-mediated xenograft rejection, including NK cells and CD8+ CTL, is a major obstacle in successful pig-to-human xenotransplantation. Human CD8+ CTL and NK cells display high cytotoxicity for pig cells, mediated at least in part by the Fas/FasL pathway.
Kwang Wook Park +9 more
core
FasL mRNA decays spontaneously.
, 2020 NC cells and LC cells were exposed to cisplatin in the culture for 48 h to increase the expression of FasL, washed with fresh medium, and then cultured in the presence or absence of LPS (100 ng/ml).
Li-Tao Yang (1305744) +6 more
core +1 more source
Immunology, EarlyView.The highly expanded TCRβ+ DNT cells in autoimmune‐prone B6/lpr mice are phenotypically and functionally different from the TCRβ+DNT cells of normal B6 mice. Conditional Egr2 deletion in B6/lpr mice not only reduces TCRβ+ DNT cell numbers but also tends to correct the phenotypic and functional abnormalities of DNT cells in B6/lpr mice. In addition, Egr2
Rujuan Dai +4 more
wiley +1 more source
Construction of FasL siRNA expression vector and its expression in lung cancer cell line A549
Chinese Journal of Lung Cancer, 2008 Background and objective Fas/FasL is a member of Tumor Necrosis Factor (TNF) super family and related to tumor cell apoptosis. It is hypothesis by forward study that activated lymphocytes is more sensitive with Fas/FasL due to up-regulation of FasL ...
Bo DENG +4 more
doaj
Journal of Periodontal Research, EarlyView.A graphical abstract recapping the different sources of dental, periodontal, and other oral‐derived mesenchymal stromal cells (MSCs) and their regenerative mechanisms and potentials. The review's article findings bridge fundamental biological science with translational advances, highlighting the significance of MSCs in craniofacial regenerative ...
Karim M. Fawzy El‐Sayed +6 more
wiley +1 more source
Frontiers in Molecular NeuroscienceExisting studies have indicated that noise induces apoptosis and necroptosis in cochlear outer hair cells (OHCs). However, the role of the extrinsic cell death pathway, initiated by death ligands in the cochlea, remains unknown.
Wenlun Wang +6 more
doaj +1 more source
RGD-FasL Induces Apoptosis in Hepatocellular Carcinoma
, 2009 Natural Science Foundation of Fujian Province [C0710046]Despite impressive results obtained in animal models, the clinical use of Fas ligand (FasL) as an anticancer drug is limited by severe toxicity.
Zhang, Jiakai +34 more
core +1 more source
Inflammatory and Immunological Basis of Periodontal Diseases
Journal of Periodontal Research, EarlyView.The periodontal lesion emerges as an evolving immunological battlefield, where host–microbiome interactions, dysregulated immune responses, fragile resolution mechanisms, and inflammophilic dysbiosis converge to shift the balance from homeostasis to unrestrained tissue destruction.
Giacomo Baima +3 more
wiley +1 more source