Results 91 to 100 of about 35,096 (229)

Expressions of Fas/DcR3 and FasL/RGD-FasL mediated apoptosis in pituitary adenoma cells [PDF]

, 2008
目的研究RGD-FasL诱导垂体腺瘤细胞株GH3、MMQ、AtT20所产生的细胞毒性效应,并探讨其机制。方法应用RT-PCR法和流式细胞仪检测肿瘤细胞上Fas、DcR3的表达。应用MTT测定法检测FasL、RGD-FasL对肿瘤细胞所产生的细胞毒性效应,并经琼脂糖凝胶电泳证实是否为该配体所诱导的凋亡。通过流式细胞仪PI染色法评价细胞周期的变化和凋亡分析。通过Western蛋白印迹法检测Caspase 8、Caspase 9、Caspase 3、Bcl-2、RANKL和JNK2的表达 ...
刘运生, 李文珠, 候永宏, 张俊卿, 田新华, 康俊龙, 庄国洪, 陈陆馗   +7 more
core  

Periodontitis and Adverse Pregnancy Outcomes: Mechanistic Evidence

Journal of Periodontal Research, EarlyView.
This narrative review aims to describe mechanisms linking periodontal diseases in pregnancy with adverse pregnancy outcomes. ABSTRACT Periodontal diseases, including both gingivitis and periodontitis, occur commonly among pregnant individuals. Both gingivitis and periodontitis are associated with adverse pregnancy outcomes (APOs) such as early ...
Gregory C. Valentine, Yiorgos A. Bobetsis, Benjamin C. Shayo, Peter Milgrom, Phoebus N. Madianos   +4 more
wiley   +1 more source

Human B cell-derived lymphoblastoid cell lines constitutively produce Fas ligand and secrete MHCII+FasL+ killer exosomes

Frontiers in Immunology, 2014
Immune suppression mediated by exosomes is an emerging concept with potentially immense utility for immunotherapy in a variety of inflammatory contexts, including allogeneic transplantation. Exosomes containing the apoptosis-inducing molecule Fas ligand (
Matthew W. Klinker, Matthew W. Klinker, Vincent eLizzio, Tamra J Reed, David A. Fox, David A. Fox, Steven K. Lundy, Steven K. Lundy   +7 more
doaj   +1 more source

A Crazy Idea: Ibn Sīnā on Hylomorphism, the Elements, Mixture and Evolutionary Processes

Theoria, EarlyView.
ABSTRACT Ibn Sīnā (c. 973‐1037), the Avicenna of Latin fame, developed a unique theory of the elements and their status in mixtures that severely challenged the views of earlier natural philosophers and in its turn was severely challenged by later Latin Schoolmen in the West.
Jon McGinnis
wiley   +1 more source

The In Situ Hybridization Expression of Fas and Fas Ligand (FasL) in Trophoblastic tissue of Aborted Women Compared with Normal Pregnancy.

مجلة كلية الطب, 2009
Background: Estimation of the in situ expression of Fas and Fas ligand (FasL) in aborted women compared with normal human pregnancy . Patients and Methods: A technique utilizing in situ hybridization(ISH) was performed to detect and determine the in situ
Amal H. Salman, Dalya B. Hana, Dhamraa W. Ahmad   +2 more
doaj   +1 more source

Physical association of FLAG-tagged mutant FasL with HA-tagged wild type FasL

, 2011
Copyright information:Taken from "Dominant inhibition of Fas ligand-mediated apoptosis due to a heterozygous mutation associated with autoimmune lymphoproliferative syndrome (ALPS) Type Ib"http://www.biomedcentral.com/1471-2350/8/41BMC Medical Genetics ...
Vishnu Reddy (33039), Christopher Makris (33038), Richard M Siegel (33041), George Pan (33034), Jay M McDonald (33040), Lixin Zheng (33036), Lilia L Bi (33033), Michael J Lenardo (33043), Janet K Dale (33037), Stephen E Straus (33044), T Prescott Atkinson (33035), Jennifer M Puck (33042)   +11 more
core   +1 more source

Loss of BID Delays FASL-Induced Cell Death of Mouse Neutrophils and Aggravates DSS-Induced Weight Loss [PDF]

, 2018
Neutrophils are key players in the early defense against invading pathogens. Due to their potent effector functions, programmed cell death of activated neutrophils has to be tightly controlled; however, its underlying mechanisms remain unclear.
Vera Genitsch, Wendy Wong, Wong, Wendy Wei-Lynn, Kaufmann, Thomas, Wicki, Simone, Genitsch, Vera, Simone Wicki, Nadia Corazza, Thomas Kaufmann, Corazza, Nadia, Ursina Gurzeler, Gurzeler, Ursina   +11 more
core   +1 more source

From scarring to healing: Emerging regenerative therapies for pulmonary fibrosis using MSCs and exosomes

Clinical and Translational Discovery, Volume 6, Issue 4, August 2026.
MSCs exert anti‐inflammatory, anti‐fibrotic and regenerative effects in pulmonary fibrosis. MSC‐derived exosomes reproduce many therapeutic benefits of parental MSCs. Preconditioning and genetic modification improve MSC therapeutic performance. Current preclinical and clinical evidence supports the translational potential of MSC‐based therapies ...
Hajar Nasiri, Farbod Khosravi, Fatemeh Eskandari, Tahereh Manoochehrabadi, Ali Samadikuchaksaraei, Ehsan Lotfi, Jila Majidi, Fatemeh Rafati, Zeynab Ghorbani   +8 more
wiley   +1 more source

Metabolic Dysfunction‐Associated Fatty Liver Disease: From Pathogenesis to Treatment

MedComm, Volume 7, Issue 7, July 2026.
Extracellular vesicles play a crucial role in interorgan crosstalk of adipose–liver and gut–liver axes and hold potential as therapeutic targets and drug delivery systems for metabolic dysfunction‐associated fatty liver disease (MAFLD). Abbreviations: AT: adipose tissue; EVs: extracellular vesicles; HL: healthy liver; NAFL: nonalcoholic fatty liver ...
Zhifu Cui, Xiaxia Du, Felix Kwame Amevor, Yaoyao Xia, You Yang, Lingbin Liu   +5 more
wiley   +1 more source

CD8+ Tissue‐Resident Memory T Cells in Health and Disease

MedComm, Volume 7, Issue 7, July 2026.
CD8+ TRM cells are at the center of immunity, mediating potent local innate and adaptive immune responses. While TRM cells mediate protective immunity against infections and tumors, they also contribute to pathological inflammation in autoimmune conditions.
Yu‐Han Ai, Ting‐Ting Xu, Sen Lin, Meng‐Yu Xiao, Yun‐Xia Lin, Hao‐Wen Ma, Yue‐Yang Liu, Yao‐Jie Wang, Lu‐Ning Yin, Mei Huang, Yong‐Da Liu, Chao Zhu, Xiao‐Ting Zhu, Ji‐Hang Yuan   +13 more
wiley   +1 more source