Results 111 to 120 of about 37,208 (191)

The Transcription Factor EGR2 Plays a Central Role in the Expansion and Function of TCRαβ + CD4 − CD8 − Double Negative T Cells in lpr Lupus Mice

open access: yesImmunology, Volume 179, Issue 2, Page 224-235, October 2026.
The highly expanded TCRβ+ DNT cells in autoimmune‐prone B6/lpr mice are phenotypically and functionally different from the TCRβ+DNT cells of normal B6 mice. Conditional Egr2 deletion in B6/lpr mice not only reduces TCRβ+ DNT cell numbers but also tends to correct the phenotypic and functional abnormalities of DNT cells in B6/lpr mice. In addition, Egr2
Rujuan Dai   +4 more
wiley   +1 more source

Building an Interleukin‐10‐Producing Identity: How B Cells Acquire Interleukin‐10 Competence and How Plasma Cell Differentiation Consolidates This Program

open access: yesImmunological Reviews, Volume 343, Issue 1, October 2026.
ABSTRACT Interleukin (IL)‐10‐producing B cells represent an archetype for the regulatory functions of B cells. Here, we review the cell‐surface receptors and transcriptional regulators that control IL‐10 expression in B cells and enable their regulatory function in vivo.
Bui Thi Cuc   +4 more
wiley   +1 more source

Distinct role of the Fas rs1800682 and FasL rs763110 polymorphisms in determining the risk of breast cancer among Han Chinese women

open access: yes, 2016
Meng Wang,1,* Zheng Wang,2,* Xi-Jing Wang,1 Tian-Bo Jin,3 Zhi-Ming Dai,4 Hua-Feng Kang,1 Hai-Tao Guan,1 Xiao-Bin Ma,1 Xing-Han Liu,1 Zhi-Jun Dai1 1Department of Oncology, Second Affiliated Hospital of Xi’an Jiaotong University, 2Department of ...
Wang M   +9 more
core  

A Fas Ligand (FasL)-Fused Humanized Antibody Against Tumor-Associated Glycoprotein 72 Selectively Exhibits the Cytotoxic Effect Against Oral Cancer Cells with a Low FasL/Fas Ratio

open access: yes, 2017
Altered expression of the Fas ligand (FasL)/Fas ratio exhibits a direct impact on the prognosis of cancer patients, and its impairment in cancer cells may lead to apoptosis resistance.
Rahul Sharma   +8 more
core   +1 more source

Glucuronyl Glucosyloleanolate: A Safe and Potent AI‐Discovered Depigmenting Saponin

open access: yesJournal of Cosmetic Dermatology, Volume 25, Issue 10, October 2026.
ABSTRACT Purpose Saponins are amphiphilic glycosides found in plants. They have long been used in traditional Asian remedies for their anti‐inflammatory, protective, and rejuvenating properties. One representative, Glucuronyl Glucosyloleanolate (GGO), was recently discovered using a combination of artificial intelligence and experimental testing as a ...
Yannick Quesnel, Michael Gold
wiley   +1 more source

DcR3 Fc administration inhibited FasL-induced apoptosis.

open access: yes, 2015
DcR3 Fc administration decreased human peripheral lymphocyte apoptosis induced by FasL. Peripheral lymphocytes cells were obtained from septic shock patients using Ficoll-Paque Plus and randomly divided into four groups: control, FasL-induced, FasL plus ...
DongYu Liang (762413)   +3 more
core   +1 more source

DAC enhances FASL-mediated cell death of GL261 glioma cells.

open access: yes, 2016
(A) GL261-OVA GDC (GDC) and GL261-OVA GIC (GIC) FASL-mediated cell death normalised to untreated controls, measured by 7AAD staining. Cells were treated 48h with 10 μM DAC and then plated for 20h with increasing concentrations of the multimeric FASL or ...
Serena Pellegatta (109687)   +13 more
core   +1 more source

原发性胆汁性肝硬化患者肝组织和外周血单个核细胞Fas、FasL的检测

open access: yesZhongguo shiyan zhenduanxue, 2007
目的通过原发性胆汁性肝硬化患者肝组织和外周血单个核细胞Fas、FasL的表达,探讨Fas、FasL在原发性胆汁性肝硬化患者发病机制中的作用。方法应用免疫组织化学技术,以兔抗Fas及兔抗FasL多克隆抗体,对20例原发性胆汁性肝硬化(PBC)患者肝组织和外周血单个核细胞中的Fas、FasL进行检测。结果18例PBC患者外周血单个核细胞检出Fas、FasL,检出率均为90%,Fas、FasL平均阳性细胞数分别为62%、59%。20例PBC患者16例Fas阳性颗粒表达于肝细胞胞浆,4例表达于肝细胞胞膜 ...
刘妍   +7 more
doaj  

The majority of FasL+ splenocytes are B cells.

open access: yes, 2013
Splenocytes from naïve mice were stained for surface expression of FasL and the cellular composition of FasL− and FasL+ subsets was examined by flow cytometry.
David A. Fox (441429)   +3 more
core   +1 more source

Human FASL ELISA assay v1

open access: yes, 2017
This protocol describes an ELISAassay for measurement of FAS ligand (FASL, CD95L)insupernatants collected from T cell dependent cytotoxicity (TDCC) cultures after BiTE® treatment.
not provided Gordon Moody   +7 more
core   +1 more source

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