Results 51 to 60 of about 37,208 (191)

T cells, the Next Big Target in Axial Spondyloarthritis?

Arthritis &Rheumatology, EarlyView.
Axial spondyloarthritis (axSpA) is a chronic inflammatory disease characterized by complex immune dysregulation, with T cells playing a central role in its pathogenesis. In this review, we synthesize current knowledge on diverse T cell subsets in axSpA, their pathogenic mechanisms, and emerging therapeutic strategies targeting these cells. We highlight
Mansi K. Aparnathi, Nigil Haroon
wiley   +1 more source

FAS/FASL gene polymorphisms in Turkish patients with chronic myeloproliferative disorders

, 2016
Introduction : Chronic myeloproliferative disorders (CMPD) are chronic myeloid hematological disorders, characterized by increased myeloid cell proliferation and fibrosis.
Filiz Vural, Zafer Gokgoz, Afig Berdeli, Sinem Nalbantoglu, Bahriye Kadriye Payzin, Seckin Cagirgan, Fusun Gediz Ozdemirkiran   +6 more
core   +1 more source

Efficacy, safety and cost‐effectiveness of CAR‐T therapy

British Journal of Clinical Pharmacology, EarlyView.
CAR T‐cells demonstrate high efficacy in blood cancers, including ALL, MM and DLBCL. Innovations target solid tumours despite challenges such as antigen escape. Combination therapies enhance the delivery and infiltration of CAR T cells. Toxicity, cost and resistance remain major barriers to clinical use.
Emina Karahmet Sher, Amina Džidić‐Krivić, Emma Pinjic, Nejra Selak, Kanita Omerbasic, Alexandar Chupin, Andrej Belancic, Almir Fajkic   +7 more
wiley   +1 more source

Extracellular Vesicles‐Based Biological Macromolecule Delivery Systems: Biogenesis, Characterization, and Emerging Clinical Applications

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Extracellular vesicles (EVs) are nanoscale membrane‐bound structures that play a pivotal role in intercellular communication by transporting bioactive molecules, including proteins, lipids, nucleic acids, and organelles, between cells. Originating from the endosomal pathway, EVs reflect the physiological and pathological status of their parent
Emine İncilay Torunoğlu, Zeynep Betül Sarı, Muhammed Emin Sarı, Erdi Can Aytar   +3 more
wiley   +1 more source

Involvement of Fas/FasL system in apoptotic signaling in testicular germ cells of male Wistar rats injected i.v. with microcystins

, 2009
Previous studies have shown that gonads were the second target organ of microcystins (MCs), and that MCs exposure exerted obvious toxic effects on male reproductive system of mammals. However, relevant molecular evidences are still lacking. Fas-signaling
Li, Huiying, Liu, Ying, Xie, P, Chinese Acad Sci, Donghu Expt Stn Lake Ecosyst, State Key Lab Freshwater Ecol & Biotechnol China, Inst Hydrobiol, Wuhan 430072, Peoples R China, Hao, Le, Xiong, Qian, Li, Guangyu, Qiu, Tong, Xie, Ping   +7 more
core   +1 more source

P2X₇ signaling promotes microsphere embolism-triggered microglia activation by maintaining elevation of Fas ligand

Journal of Neuroinflammation, 2012
Background The cerebral microvascular occlusion elicits microvascular injury which mimics the different degrees of stroke severity observed in patients, but the mechanisms underlying these embolic injuries are far from understood.
Lu Ying-mei, Tao Rong-rong, Huang Ji-yun, Li Li-tao, Liao Mei-hua, Li Xiao-ming, Fukunaga Kohji, Hong Ze-Hui, Han Feng   +8 more
doaj   +1 more source

Anticancer potential of berberine: Molecular pathways and current clinical trial perspectives

JSFA reports, EarlyView.
Abstract Cancer is constantly rising mortality rates due to its late prognosis, poor management, and expensive treatment. Multi‐sectoral approaches for cancer management include hygienic practices, synthetic drug exploitation, radiation therapy, and diet modifications.
Muhammad Maaz, Muhammad Tauseef Sultan, Muhammad Israr, Waqas Ahmad Khan, Fahad Tanveer, Muzzamal Hussain, Muhammad Imran, Ahmed Mujtaba, Anjuman Gul Memon, Muhammad Atif, Entessar Al Jbawi   +10 more
wiley   +1 more source

FasL⁺ B cells express higher levels of the IL-5 receptor than FasL

, 2013
− B cells. (A) Histograms comparing surface expression of CD125 in CD19−, CD19+FasL− and CD19+FasL+ cells. (B) Quantification of median fluorescence intensity of CD125 expression in CD19+FasL− and CD19+FasL+ B cells in replicate animals (mean ± SEM ...
David A. Fox (441429), Matthew W. Klinker (441427), Tamra J. Reed (441428), Steven K. Lundy (441430)   +3 more
core   +1 more source

Image_3_Fas/FasL Contributes to HSV-1 Brain Infection and Neuroinflammation.jpeg

, 2021
The Fas/FasL pathway plays a key role in immune homeostasis and immune surveillance. In the central nervous system (CNS) Fas/FasL is involved in axonal outgrowth and adult neurogenesis.
Kristina Eriksson (320210), Karolina Thörn (218971), Katarzyna Skulska (11354211), Malgorzata Krzyzowska (587002), Andrzej Kowalczyk (3970700)   +4 more
core   +1 more source

Fas Ligand DNA Enhances a Vaccination Effect by Coadministered DNA Encoding a Tumor Antigen through Augmenting Production of Antibody against the Tumor Antigen

Journal of Immunology Research, 2015
Interaction of Fas and Fas ligand (FasL) plays an important role in the regulation of immune responses by inducing apoptosis of activated cells; however, a possible role of FasL in DNA vaccination has not been well understood.
Boya Zhong, Guangyu Ma, Ayako Sato, Osamu Shimozato, Hongdan Liu, Quanhai Li, Masato Shingyoji, Yuji Tada, Koichiro Tatsumi, Hideaki Shimada, Kenzo Hiroshima, Masatoshi Tagawa   +11 more
doaj   +1 more source