Results 31 to 40 of about 37,208 (191)

Impact of FasL Stimulation on Sclerostin Expression and Osteogenic Profile in IDG-SW3 Osteocytes

Biology, 2021
The Fas ligand (FasL) is known from programmed cell death, the immune system, and recently also from bone homeostasis. As such, Fas signalling is a potential target of anti-osteoporotic treatment based on the induction of osteoclastic cell death.
Adela Kratochvilova, Alice Ramesova, Barbora Vesela, Eva Svandova, Herve Lesot, Reinhard Gruber, Eva Matalova   +6 more
doaj   +1 more source

Figure S2 from Toxicology and Pharmacokinetic Studies in Mice and Nonhuman Primates of the Nontoxic, Efficient, Targeted Hexameric FasL: CTLA4-FasL

, 2020
Transient changes in blood counts in CTLA4-FasL treated mice were prevented by ...
Yosi Meir Gozlan (6742385), Fanny Shkedy (15084763), Alexandra Aronin (469292), Shira Amsili (377500), Tatyana B. Prigozhina (15084754), Liat Ben Gigi–Tamir (15084757), Kobi Tzdaka (469294), Jitka Yehudith Sagiv (15084760), Mark L. Tykocinski (15077647), Michal Dranitzki Elhalel (466764), Efi Makdasi (10022885), Noam Shani (469295)   +11 more
core   +1 more source

Figure S3 from Toxicology and Pharmacokinetic Studies in Mice and Nonhuman Primates of the Nontoxic, Efficient, Targeted Hexameric FasL: CTLA4-FasL

, 2020
Elevated globulin and no significant increase in liver enzyme levels in CTLA4-FasL treated ...
Yosi Meir Gozlan (6742385), Fanny Shkedy (15084763), Alexandra Aronin (469292), Shira Amsili (377500), Tatyana B. Prigozhina (15084754), Liat Ben Gigi–Tamir (15084757), Kobi Tzdaka (469294), Jitka Yehudith Sagiv (15084760), Mark L. Tykocinski (15077647), Michal Dranitzki Elhalel (466764), Efi Makdasi (10022885), Noam Shani (469295)   +11 more
core   +1 more source

Impact of cell death pathway genes Fas 21377AA and FasL 2844CC polymorphisms on the risk of developing non-small cell lung cancer

Egyptian Journal of Medical Human Genetics, 2018
Background: The signalling pathway Fas and FasL system plays a fundamental role in the regulation of apoptotic cell death and any disturbance of this pathway has been shown to promote immune escape and tumorigenesis.
Nada Ezzeldin, Hebatallah Farouk, Dina M. Kandil, Amira Darwish, Ahmed El-Bastawisy   +4 more
doaj   +1 more source

Opposing roles for membrane bound and soluble Fas ligand in glaucoma-associated retinal ganglion cell death. [PDF]

PLoS ONE, 2011
Glaucoma, the most frequent optic neuropathy, is a leading cause of blindness worldwide. Death of retinal ganglion cells (RGCs) occurs in all forms of glaucoma and accounts for the loss of vision, however the molecular mechanisms that cause RGC loss ...
Meredith S Gregory, Caroline G Hackett, Emma F Abernathy, Karen S Lee, Rebecca R Saff, Andreas M Hohlbaum, Krishna-Sulayman L Moody, Maura W Hobson, Alexander Jones, Paraskevi Kolovou, Saoussen Karray, Andrea Giani, Simon W M John, Dong Feng Chen, Ann Marshak-Rothstein, Bruce R Ksander   +15 more
doaj   +1 more source

miRNA-19a exerts an anti-apoptotic effect in spinal cord injured rats via the PTEN pathway

Archives of Medical Science, 2019
Introduction Contusion spinal cord injury is involved in a number of cellular, biochemical and molecular changes. We studied the overall expression pattern of miRNAs on day 1 and 3 after spinal cord injury and the involved pathways.
Lu Chen, Xing Li, Jianping Zhu, Binwu Xu, Yurong Gu   +4 more
doaj   +1 more source

Plasma Levels of sFas-sFasL and FASL Gene Expression Are Associated with Tuberculosis

Biomolecules, 2022
Apoptosis of macrophages infected by Mycobacterium tuberculosis via Fas-FasL is an important immune mechanism against infection. This study investigated the association of tuberculosis (TB) with the presence of the polymorphisms FAS -670A/G and FASL ...
Iury de Paula Souza, Ednelza da Silva Graça Amoras, Francisca Dayse Martins de Sousa, Paulo Victor Negrão Raiol de Sousa, Sandra Souza Lima, Izaura Maria Vieira Cayres-Vallinoto, Ricardo Ishak, Antonio Carlos Rosário Vallinoto, Maria Alice Freitas Queiroz   +8 more
doaj   +1 more source

JAK-STAT-mediated chronic inflammation impairs cytotoxic T lymphocyte activation to decrease anti-PD-1 immunotherapy efficacy in pancreatic cancer

OncoImmunology, 2017
Human pancreatic cancer does not respond to immune check point blockade immunotherapy. One key feature of pancreatic cancer is the association between its progression and chronic inflammation.
Chunwan Lu, Asif Talukder, Natasha M. Savage, Nagendra Singh, Kebin Liu   +4 more
doaj   +1 more source

CHARACTERISTICS OF SIGNALING PATHWAYS MEDIATING A CYTOTOXIC EFFECT OF DENDRITIC CELLS UPON ACTIVATED Т LYMPHOCYTES AND NK CELLS

Медицинская иммунология, 2014
. Cytotoxic/pro-apoptogenic effects of IFNα-induced dendritic cells (IFN-DCs) directed against Т-lymphocytes and NK cells were investigated in healthy donors.
T. V. Tyrinova, O. Yu. Leplina, M. A. Tikhonova, L. V. Sakhno, A. A. Ostanin, E. R. Chernykh   +5 more
doaj   +1 more source

The role of FasR/FasL system in pathogenesis of myeloprolyferative neoplasms [PDF]

Archives of Biological Sciences, 2010
Myeloproliferative neoplasms (MPN) are hematological malignancies characterized by uncontrolled cell proliferation and impaired apoptosis. The FasR/FasL system is involved in the control of apoptosis in different cell types. Here we have investigated the
Spasovski Vesna, Tosić Natasa, Kostić Tatjana, Zukić Branka, Stojiljković Maja, Čolović Milica, Pavlović Sonja   +6 more
doaj   +1 more source