Results 11 to 20 of about 37,208 (191)

Fas/FasL Contributes to HSV-1 Brain Infection and Neuroinflammation

Frontiers in Immunology, 2021
The Fas/FasL pathway plays a key role in immune homeostasis and immune surveillance. In the central nervous system (CNS) Fas/FasL is involved in axonal outgrowth and adult neurogenesis.
Malgorzata Krzyzowska, Malgorzata Krzyzowska, Malgorzata Krzyzowska, Andrzej Kowalczyk, Katarzyna Skulska, Karolina Thörn, Kristina Eriksson   +6 more
doaj   +2 more sources

FasL Modulates Expression of Mmp2 in Osteoblasts [PDF]

Frontiers in Physiology, 2018
FasL is a well-known actor in the apoptotic pathways but recent reports have pointed to its important novel roles beyond cell death, as observed also for bone cells.
Eva Svandova, Eva Svandova, Barbora Vesela, Barbora Vesela, Hervé Lesot, Jeremy Sadoine, Anne Poliard, Eva Matalova, Eva Matalova   +8 more
doaj   +2 more sources

Systemic FasL and TRAIL neutralisation reduce leishmaniasis induced skin ulceration. [PDF]

PLoS Neglected Tropical Diseases, 2010
Cutaneous leishmaniasis (CL) is caused by Leishmania infection of dermal macrophages and is associated with chronic inflammation of the skin. L. aethiopica infection displays two clinical manifestations, firstly ulcerative disease, correlated to a ...
Geremew Tasew, Susanne Nylén, Thorsten Lieke, Befekadu Lemu, Hailu Meless, Nicolas Ruffin, Dawit Wolday, Abraham Asseffa, Hideo Yagita, Sven Britton, Hannah Akuffo, Francesca Chiodi, Liv Eidsmo   +12 more
doaj   +2 more sources

Ac-SDKP modulates apoptosis via HSP27 and the FAS/FASL and mitochondrial axes. [PDF]

Animal Model Exp Med
Schematic diagram of Ac‐SDKP regulating the FAS/FASL and mitochondrial apoptosis pathways via HSP27. Ac‐SDKP inhibits HSP27 expression, activates the FAS/FASL pathway and Caspase‐3 signaling, increases Caspase‐8 and Caspase‐3 expression, and induces cell apoptosis.
Guo W, Yan J, Li W, Wang J, Liu L, Zhang C, Cao W, Yao S, Gong H, He Y, Zhou Z, Chen S, Feng L, Deng H.   +13 more
europepmc   +2 more sources

Species difference in the expression of Fas and Fas ligand in mature mammalian spermatozoa

Czech Journal of Animal Science, 2017
Although it has been proposed that the Fas and Fas ligand (FasL) may protect ejaculated spermatozoa against apoptosis induced by lipoperoxidative damage and against lymphocytes present in the female genital tract, studies reported conflicting results on ...
Youwei Li, Mingju Sun, Jiang Zhu, Guangzhong Jiao, Juan Lin, Haibo Dong, Jinghe Tan, Jiabo Zhou   +7 more
doaj   +1 more source

A connection between levels of soluble Fas and Fas ligand in the aqueous humor and the parameters of structural and functional damage of glaucoma patients [PDF]

Srpski Arhiv za Celokupno Lekarstvo
Introduction/Objective Fas ligand (FasL) induces apoptosis when interacting with the Fas-receptor. The aim was to determine the concentration of soluble Fas (sFas) and soluble FasL (sFasL) in the aqueous humor (AH) of open-angle glaucoma patients, and ...
Trenkić Marija, Jevtović-Stoimenov Tatjana, Bašić Jelena, Stamenković Miroslav, Jocić-Đorđević Jasmina, Trenkić Milan   +5 more
doaj   +1 more source

The role of apoptosis in pathogenesis of type 1 diabetes mellitus

Сахарный диабет, 2010
Type 1 diabetes mellitus (DM1) is known to be associated with progressive destruction of pancreatic beta-cells. Apoptosis plays the key role in this destructiveprocess.
Elena Vladimirovna Pekareva, Tatiana Vasil'evna Nikonova, Olga Mikhailovna Smirnova   +2 more
doaj   +1 more source

FasL is a catabolic factor in alveolar bone homeostasis. [PDF]

, 2023
AIM Fas ligand (FasL) belongs to the tumor necrosis factor (TNF) superfamily regulating bone turnover, inflammation, and apoptosis. The appendicular and axial skeleton phenotype of mature Faslgld mice was reported.
Heimel, Patrick, Lee, Jung Seok, Patrick Heimel, Tangl, Stefan, Panahipour, Layla, Julie Marchesan, Stefan Tangl, Lettner, Stefan, Layla Panahipour, Gruber, Reinhard, Matalová, Eva, Reinhard Gruber, Jung Seok Lee, Marchesan, Julie, Karol Alí Apaza Alccayhuaman, Karol Alí, Apaza Alccayhuaman, Apaza Alccayhuaman, Karol Alí, Ulrike Kuchler, Stefan Lettner, Kuchler, Ulrike, Eva Matalová   +20 more
core   +2 more sources

Enhanced expression of Fas Ligand (FasL) in the lower airways of patients with fibrotic interstitial lung diseases (ILDs)

Folia Histochemica et Cytobiologica, 2012
The exact role of FasL, and particularly its soluble and membrane-bound forms, in the development of chronic ILDs and lung fibrosis has not been extensively explored.
Teresa Iwaniec, Marek Jankowski, Tomasz Wandtke, Agnieszka Jarzemska, Grzegorz Przybylski, Adam Szpechciński, Andrzej Dyczek, Barbara Balicka-Ślusarczyk, Piotr Kopiński, Joanna Chorostowska-Wynimko   +9 more
doaj   +1 more source

Fas/FasL Signaling Regulates CD8 Expression During Exposure to Self-Antigens

Frontiers in Immunology, 2021
Activation of self-reactive CD8+ T cells induces a peripheral tolerance mechanism that involves loss of CD8 expression. Because genetic deficiency of Fas and Fasl causes the accumulation of double-negative (DN; CD3+ TCR-αβ+ CD4- CD8-) T cells that have ...
Giovanna Flores-Mendoza, Giovanna Flores-Mendoza, Noé Rodríguez-Rodríguez, Rosa M. Rubio, Iris K. Madera-Salcedo, Florencia Rosetti, José C. Crispín, José C. Crispín   +7 more
doaj   +1 more source