Results 21 to 30 of about 30,088 (148)
Egyptian Journal of Medical Human Genetics, 2018 Background: The signalling pathway Fas and FasL system plays a fundamental role in the regulation of apoptotic cell death and any disturbance of this pathway has been shown to promote immune escape and tumorigenesis.
Nada Ezzeldin +4 more
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The role of FasR/FasL system in pathogenesis of myeloprolyferative neoplasms [PDF]
Archives of Biological Sciences, 2010 Myeloproliferative neoplasms (MPN) are hematological malignancies characterized by uncontrolled cell proliferation and impaired apoptosis. The FasR/FasL system is involved in the control of apoptosis in different cell types. Here we have investigated the
Spasovski Vesna +6 more
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Opposing roles for membrane bound and soluble Fas ligand in glaucoma-associated retinal ganglion cell death. [PDF]
PLoS ONE, 2011 Glaucoma, the most frequent optic neuropathy, is a leading cause of blindness worldwide. Death of retinal ganglion cells (RGCs) occurs in all forms of glaucoma and accounts for the loss of vision, however the molecular mechanisms that cause RGC loss ...
Meredith S Gregory +15 more
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Plasma Levels of sFas-sFasL and FASL Gene Expression Are Associated with Tuberculosis
Biomolecules, 2022 Apoptosis of macrophages infected by Mycobacterium tuberculosis via Fas-FasL is an important immune mechanism against infection. This study investigated the association of tuberculosis (TB) with the presence of the polymorphisms FAS -670A/G and FASL ...
Iury de Paula Souza +8 more
doaj +1 more source
miRNA-19a exerts an anti-apoptotic effect in spinal cord injured rats via the PTEN pathway
Archives of Medical Science, 2019 Introduction Contusion spinal cord injury is involved in a number of cellular, biochemical and molecular changes. We studied the overall expression pattern of miRNAs on day 1 and 3 after spinal cord injury and the involved pathways.
Lu Chen +4 more
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OncoImmunology, 2017 Human pancreatic cancer does not respond to immune check point blockade immunotherapy. One key feature of pancreatic cancer is the association between its progression and chronic inflammation.
Chunwan Lu +4 more
doaj +1 more source
Медицинская иммунология, 2014 . Cytotoxic/pro-apoptogenic effects of IFNα-induced dendritic cells (IFN-DCs) directed against Т-lymphocytes and NK cells were investigated in healthy donors.
T. V. Tyrinova +5 more
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Systemic FasL and TRAIL neutralisation reduce leishmaniasis induced skin ulceration. [PDF]
PLoS Neglected Tropical Diseases, 2010 Cutaneous leishmaniasis (CL) is caused by Leishmania infection of dermal macrophages and is associated with chronic inflammation of the skin. L. aethiopica infection displays two clinical manifestations, firstly ulcerative disease, correlated to a ...
Geremew Tasew +12 more
doaj +1 more source
Advanced Science, EarlyView.Antigenic peptides Aβ42 and E7 self‐assemble into nanofibrils; APTES and TEOS induce SiO2 NP formation on these fibrils to form SiO2@fibril nanovaccines, which activate BMDCs in vitro. In vivo, SiO2@Aβ42 fibril nanovaccines alleviate AD symptoms and clear Aβ42 plaques in APP/PS1 mice, and SiO2@E7 fibril nanovaccines inhibit tumor growth and promote ...
Xuecheng Yang +6 more
wiley +1 more source
The Pan African Medical Journal, 2019 INTRODUCTION: The number of HIV exposed uninfected (HEU) infants is increasing as vertical transmission is reducing. This subpopulation requires more investigations.
Béatrice Dambaya +13 more
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