Results 21 to 30 of about 35,096 (229)

Figure S1 from Toxicology and Pharmacokinetic Studies in Mice and Nonhuman Primates of the Nontoxic, Efficient, Targeted Hexameric FasL: CTLA4-FasL

, 2020
(a) Receptors expression on human cell lines and mouse BCL-1 splenocytes. (b) Anti CTLA4-FasL antibodies are formed in treated mice. (c) Neutralizing anti CTLA4-FasL antibodies are formed in treated mice.
Yosi Meir Gozlan (6742385), Fanny Shkedy (15084763), Alexandra Aronin (469292), Shira Amsili (377500), Tatyana B. Prigozhina (15084754), Liat Ben Gigi–Tamir (15084757), Kobi Tzdaka (469294), Jitka Yehudith Sagiv (15084760), Mark L. Tykocinski (15077647), Michal Dranitzki Elhalel (466764), Efi Makdasi (10022885), Noam Shani (469295)   +11 more
core   +1 more source

Modulation of CD8+ memory stem T cell activity and glycogen synthase kinase 3β inhibition enhances anti-tumoral immunity in gastric cancer

OncoImmunology, 2018
The potential contributions of CD8+ memory stem T cells to anti-tumor immunity and immunotherapy responses in gastric cancer has not been demonstrated.
Jin-yu Zhang, Yong-liang Zhao, Yi-pin Lv, Ping Cheng, Weisan Chen, Mubin Duan, Yong-sheng Teng, Ting-ting Wang, Liu-sheng Peng, Fang-yuan Mao, Yu-gang Liu, Xiao-long Fu, Pei-wu Yu, Ping Luo, Wei-jun Zhang, Quan-ming Zou, Yuan Zhuang   +16 more
doaj   +1 more source

Mechanism of nuclear factor of activated T-cells mediated FasL expression in corticosterone -treated mouse Leydig tumor cells

BMC Cell Biology, 2008
Background Fas and FasL is important mediators of apoptosis. We have previously reported that the stress levels of corticosterone (CORT, glucocorticoid in rat) increase expression of Fas/FasL and activate Fas/FasL signal pathway in rat Leydig cells ...
Wang Qian, Chen Yong, Chai Wei-Ran, Gao Hui-Bao   +3 more
doaj   +1 more source

Table S1, S2 from Toxicology and Pharmacokinetic Studies in Mice and Nonhuman Primates of the Nontoxic, Efficient, Targeted Hexameric FasL: CTLA4-FasL

, 2020
Table S1. Summary of the Toxicokinetic Parameters of CTLA4-FasL in mouse Plasma at the first injection (Day 1) and the third injection (Day 5) Table S2.
Yosi Meir Gozlan (6742385), Fanny Shkedy (15084763), Alexandra Aronin (469292), Shira Amsili (377500), Tatyana B. Prigozhina (15084754), Liat Ben Gigi–Tamir (15084757), Kobi Tzdaka (469294), Jitka Yehudith Sagiv (15084760), Mark L. Tykocinski (15077647), Michal Dranitzki Elhalel (466764), Efi Makdasi (10022885), Noam Shani (469295)   +11 more
core   +1 more source

Fas/FasL Signaling Regulates CD8 Expression During Exposure to Self-Antigens

Frontiers in Immunology, 2021
Activation of self-reactive CD8+ T cells induces a peripheral tolerance mechanism that involves loss of CD8 expression. Because genetic deficiency of Fas and Fasl causes the accumulation of double-negative (DN; CD3+ TCR-αβ+ CD4- CD8-) T cells that have ...
Giovanna Flores-Mendoza, Giovanna Flores-Mendoza, Noé Rodríguez-Rodríguez, Rosa M. Rubio, Iris K. Madera-Salcedo, Florencia Rosetti, José C. Crispín, José C. Crispín   +7 more
doaj   +1 more source

Figure S4 from Toxicology and Pharmacokinetic Studies in Mice and Nonhuman Primates of the Nontoxic, Efficient, Targeted Hexameric FasL: CTLA4-FasL

, 2020
Elevation of pro-inflammatory cytokines in CTLA4-FasL treated mice was prevented by ...
Yosi Meir Gozlan (6742385), Fanny Shkedy (15084763), Alexandra Aronin (469292), Shira Amsili (377500), Tatyana B. Prigozhina (15084754), Liat Ben Gigi–Tamir (15084757), Kobi Tzdaka (469294), Jitka Yehudith Sagiv (15084760), Mark L. Tykocinski (15077647), Michal Dranitzki Elhalel (466764), Efi Makdasi (10022885), Noam Shani (469295)   +11 more
core   +1 more source

Decidual Macrophages Are Significantly Increased in Spontaneous Miscarriages and Over-Express FasL [PDF]

, 2012
Decidual macrophages (DM) are the second most abundant population in the fetal-maternal interface. Their role has been so far identified as being local immuno-modulators favoring the maternal tolerance to the fetus.
Iordanis Navrozoglou, Darius Dian, Antonis Makrigiannakis, Sabine Guenther, Anz, David, Jeschke, Udo, Klaus Friese, Udo Jeschke, Thomas Vrekoussis, Vrekoussis, Thomas, Knabl, Julia, Dian, Darius, Julia Knabl, Bayer, Birgit, Heublein, Sabine, Navrozoglou, Iordanis, Friese, Klaus, Sabine Heublein, Makrigiannakis, Antonis, David Anz, Guenther, Sabine, Birgit Bayer   +21 more
core   +1 more source

Soluble Fas Ligand Is Essential for Blister Formation in Pemphigus

Frontiers in Immunology, 2018
Pemphigus is a blistering disease characterized by pemphigus autoantibodies (PVIgG) directed mostly against desmogleins (Dsgs), resulting in the loss of keratinocyte adhesion (acantholysis).
Roberta Lotti, En Shu, Tiziana Petrachi, Alessandra Marconi, Elisabetta Palazzo, Marika Quadri, Ann Lin, Lorraine A. O’Reilly, Lorraine A. O’Reilly, Carlo Pincelli   +9 more
doaj   +1 more source

Figure S5 from Toxicology and Pharmacokinetic Studies in Mice and Nonhuman Primates of the Nontoxic, Efficient, Targeted Hexameric FasL: CTLA4-FasL

, 2020
Elevation of pro-inflammatory cytokines in CTLA4-FasL treated monkeys was prevented by ...
Yosi Meir Gozlan (6742385), Fanny Shkedy (15084763), Alexandra Aronin (469292), Shira Amsili (377500), Tatyana B. Prigozhina (15084754), Liat Ben Gigi–Tamir (15084757), Kobi Tzdaka (469294), Jitka Yehudith Sagiv (15084760), Mark L. Tykocinski (15077647), Michal Dranitzki Elhalel (466764), Efi Makdasi (10022885), Noam Shani (469295)   +11 more
core   +1 more source

The Fas-FasL system and colorectal tumours [PDF]

Journal of Clinical Pathology, 2002
We read with interest the article of Bennett et al ,1 showing that the coexpression of Fas–Fas ligand (FasL) did not elicit increased apoptosis in colonic tumour cells. They suggested that colonocytes acquire resistance to Fas mediated apoptosis early in the transformation process. The Cork Group has greatly contributed to unravelling the riddle of the
C A Rubio, B Jacobsson, M W Bennett, J O'Connell, A Houston, J Kelly, J K Collins, F Shanahan, G C O'Sullivan   +8 more
openaire   +2 more sources