Results 231 to 240 of about 115,762 (301)
Soluble FAS ligand is not required for pancreatic islet inflammation or beta-cell destruction in non-obese diabetic mice. [PDF]
Cell Death Discov, 2019 Trivedi PM +8 more
europepmc +1 more source
British Journal of Pharmacology, Volume 183, Issue 5, Page 990-1008, March 2026.Background and Purpose Inflammation plays a crucial role in the development and progression of numerous acute and chronic diseases such as myocardial infarction (MI) and heart failure. Targeting ADAM proteases, particularly ADAM10, holds promise for fine‐tuning inflammatory responses.
Erik Klapproth +16 more
wiley +1 more source
Many Th Cell Subsets Have Fas Ligand-Dependent Cytotoxic Potential. [PDF]
J Immunol, 2018 Kotov DI +3 more
europepmc +1 more source
Expression of the CXCR4 S338X Variant Improves Anti‐Leukemia Efficacy of Anti‐CD19 CAR‐T Cells
Cancer Science, Volume 117, Issue 3, Page 613-630, March 2026.Under normal conditions, CXCL12 stimulation induces CXCR4 degradation. In contrast, CAR19‐T cells expressing the CXCR4 S338X variant maintain receptor stability and sustain ERK and AKT signaling, which supports T‐cell effector function, migration, and survival. Therefore, the enhanced anti‐leukemic activity is conferred by CXCR4 S338X expression in CAR‐
Yushu Mao +12 more
wiley +1 more source
Pancreatic Allografts: Identification of Useful Biomarkers of Rejection and Beyond [PDF]
Lawson, C
core +1 more source
Clinical and Translational Science, Volume 19, Issue 3, March 2026.ABSTRACT Receptor‐interacting serine/threonine‐protein kinase 1 (RIPK1) inhibitors are being investigated for chronic inflammatory diseases such as rheumatoid arthritis, inflammatory bowel disease, and psoriasis. Ocadusertib is a potent and selective allosteric inhibitor of RIPK1 and is currently being studied in clinical trials.
Simon J. Shaw +11 more
wiley +1 more source
The FEBS Journal, Volume 293, Issue 5, Page 1358-1375, March 2026.Multimeric IgM‐fragment crystallizable region (Fc) fragments retain the ability to bind C1q and initiate the classical complement pathway, leading to C4 activation and deposition in vitro. However, the Fc cores can also inhibit complement‐dependent cytotoxicity by competing with surface‐bound antibodies for C1q engagement.
Andrea J. Pinto +9 more
wiley +1 more source
Survival of isolated human preantral follicles after vitrification: Analyses of morphology and Fas ligand and caspase-3 mRNA expression. [PDF]
Clin Exp Reprod Med, 2019 Wiweko B +8 more
europepmc +1 more source
Immunology &Cell Biology, Volume 104, Issue 3, Page 276-311, March 2026.In this study, we used Foxp3‐fatemapping mice to examine the cell lineage stability of Treg cells in pregnancy. Ex‐Foxp3 cells were identified in gestational tissues. However, Treg cells retained lineage stability with no increased ex‐Foxp3 generation, regardless of inflammatory challenges that induce preterm birth.
Kerrie L Foyle +6 more
wiley +1 more source
Sex‐Specific Factors Influencing HIV Infection
Immunological Reviews, Volume 338, Issue 1, March 2026.ABSTRACT Immune responses are key in controlling viral infections such as HIV‐1, which remains a global challenge to public health. X/Y‐chromosome‐encoded genes and sex steroid hormones can modulate immune cells and drive distinct patterns of gene and protein expression involved in antiviral function, impacting sex‐dependent immune responses and ...
Maria Pujantell, Marcus Altfeld
wiley +1 more source