Journal of Extracellular Vesicles, Volume 15, Issue 2, February 2026.ABSTRACT T cell and NK92 cell‐derived extracellular vesicles or artificial cell‐derived vesicles (ACDVs) exhibit anti‐cancer effects through inherited cytotoxic proteins like perforin and granzyme or transmembrane receptors like FasL and TRAIL. The anti‐cancer potential of artificial T and NK vesicles has been improved by attaching targeting moieties ...
Brijesh Parlekar +7 more
wiley +1 more source
Brief ex vivo Fas-ligand incubation attenuates GvHD without compromising stem cell graft performance. [PDF]
Bone Marrow Transplant, 2020 Levy-Barazany H +17 more
europepmc +1 more source
A regulatory element in the CD95 (APO-1/Fas) ligand promoter is essential for responsiveness to TCR-mediated activation [PDF]
, 1998 Min Li‐Weber +5 more
openalex +1 more source
Journal of Extracellular Biology, Volume 5, Issue 2, February 2026.ABSTRACT The interaction between mutated leucine‐rich repeat kinase 2 (LRRK2) and the death adaptor protein FADD accounts for apoptotic death of dopaminergic neurons in familial Parkinson's disease (PD) driven by LRRK2 mutations. Disrupting this pathogenic interaction using constrained peptides is a promising therapeutic strategy to mitigate apoptotic ...
Yaochao Zheng +6 more
wiley +1 more source
Peripheral Nerves in Cancer: Regulatory Roles and Therapeutic Strategies
MedComm, Volume 7, Issue 2, February 2026.The interaction between cancer cells and peripheral nerves: (1) tumor cells could induce the growth of new neural axons and constructing a neural fiber network within the tumor tissue through secreting nerve growth factors; (2) nerve‐derived bioactive molecules can induce perineural invasion of tumor and regulate the malignant phenotype of tumor, such ...
Yan Fu +6 more
wiley +1 more source
The pro-survival Bcl-2 family member A1 delays spontaneous and FAS ligand-induced apoptosis of activated neutrophils. [PDF]
Cell Death Dis, 2020 Schenk RL +5 more
europepmc +1 more source
Induction of Tolerance to Cardiac Allografts Using Donor Splenocytes Engineered to Display on Their Surface an Exogenous Fas Ligand Protein [PDF]
, 2008 Esma S. Yolcu +6 more
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Proximal Pulmonary Artery Stiffening as a Biomarker of Cardiopulmonary Aging
Aging Cell, Volume 25, Issue 2, February 2026.Mouse models revealed age‐associated increased circumferential stiffness of the proximal pulmonary artery that was associated with reorientation of collagen and decreased function of the lung and right ventricle. Age‐related transcriptional changes were indicative of senescence, ECM turnover, TGFβ signaling, and altered intercellular signaling among ...
Ruben De Man +22 more
wiley +1 more source
MicroRNA-214-5p protects against myocardial ischemia reperfusion injury through targeting the FAS ligand [PDF]
, 2019 Yuan Lu +10 more
openalex +1 more source