Results 251 to 260 of about 115,762 (301)

Fas ligand: receptor or ligand?

Apoptosis, 1999
In this review, we chronicle the discovery, biochemical characterization, and assignment of Fas (CD95) as receptor and Fas Ligand (FasL, CD95L) as ligand. We review the functional descriptions of the molecules as death-inducing receptor and ligand or as mediators of cell division and/or growth arrest.
M K, Newell, J, Desbarats
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Fas Ligand-Induced Apoptosis

Annual Review of Genetics, 1999
▪ Abstract  The immune response is regulated not only by cell proliferation and differentiation, but also by programmed cell death, or apoptosis. In response to various stimuli, death factors bind to their respective receptors and activate the apoptotic death program in target cells.
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Expression of Fas‐Fas Ligand in Murine Testis

American Journal of Reproductive Immunology, 1999
Xu JP, Li X, Mori E, Guo MW, Matsuda I, Takaichi H, Amano T, Mori T. Expression of Fas‐Fas ligand in murine testis. AJRI 1999; 42:381–388 © Munksgaard, CopenhagenPROBLEM: During spermatogenesis, it has been suggested that the number of germ cells to be matured is regulated and restricted through the apoptotic mechanism.
J P, Xu, X, Li, E, Mori, M W, Guo, I, Matsuda, H, Takaichi, T, Amano, T, Mori   +7 more
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Targeting the Fas/Fas ligand pathway in cancer

Expert Opinion on Therapeutic Targets, 2005
Fas is a transmembrane receptor that can induce apoptosis after cross-linking with either agonistic antibodies or with Fas ligand (FasL). Although originally described as an important regulator of peripheral immune homeostasis, accumulating evidence suggests that the Fas/FasL system plays an important role in tumour development.
Darren I, O'Brien, Ken, Nally, Raymond G, Kelly, Terrence M, O'Connor, Fergus, Shanahan, Joe, O'Connell   +5 more
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Fas and Fas ligand: lpr and gld mutations

Immunology Today, 1995
Fas ligand (FasL) is a death factor that binds to its receptor, Fas, and induces apoptosis. Two mutations that accelerate autoimmune disease, lpr and gld, are known to correspond to mutations within genes encoding Fas and FasL, respectively. Here, Shigekazu Nagata and Takashi Suda summarize current knowledge of Fas and FasL, and discuss the ...
S, Nagata, T, Suda
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Fas and Fas Ligand Expression in Pancreatic Adenocarcinoma

Pancreas, 2002
Fas and Fas ligand (FasL) mediate apoptosis of tumor cells in immune surveillance, and expression of FasL by tumors may mediate their counterattack on cytotoxic lymphocytes. Both proteins are expressed in most if not all pancreatic carcinoma cell lines, but their study in primary human tumors has been limited.We performed Fas and FasL ...
Nat L, Pernick, Fazlul H, Sarkar, Pam, Tabaczka, Glenn, Kotcher, John, Frank, N Volkan, Adsay   +5 more
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Fas and Fas ligand expression in Alzheimer's disease

Acta Neuropathologica, 2001
The Fas/Fas ligand (L) signaling system has been implicated in the control of cell death and cell survival of T and B lymphocytes and in a variety of cell types under particular pathological conditions. In the present study we examined the expression of Fas and Fas-L, by Western blotting and immunohistochemistry, in the human frontal cortex and ...
I, Ferrer, B, Puig, J, Krupinsk, M, Carmona, R, Blanco   +4 more
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Fas and Fas‐ligand expression in seminomatous testes

APMIS, 1999
Sixteen seminomas with surrounding tissue containing normal and precancerous (cis) seminiferous tubules were examined for the expression of Fas (CD95, APO‐1) and Fas ligand (FasL) (CD95L). This was done by analyzing frozen specimens using immunohistochemistry with antibodies directed against Fas and FasL.
O, Braendstrup, B, Bols, L, Jensen
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CD95 (Fas) Ligand

1997
CD95 (Fas/APO-1) is a 45 kD cell surface glycoprotein and member of the tumor necrosis factor receptor superfamily (Nagata and Golstein 1995; Itoh et al. 1991; Oehm et al. 1992; Watanabe-Fukunaga et al. 1992a; Smith et al. 1994). Although CD95 is expressed in many tissues including liver, heart, gut, skin and ovaries (Watanabe-Fukunaga et al.
Richard C. Duke, Paul B. Nash, Mary S. Schleicher, Cynthia Richards, Jodene Moore, Evan Newell, Alex Franzusoff, Donald Bellgrau   +7 more
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Fas ligand in human serum

Nature Medicine, 1996
The Fas ligand (FasL), a member of the tumor necrosis factor family, induces apoptosis in Fas-bearing cells. The membrane-bound human FasL was found to be converted to a soluble form (sFasL) by the action of a matrix metalloproteinase-like enzyme. Two neutralizing monoclonal anti-human FasL antibodies were identified, and an enzyme-linked immunosorbent
M, Tanaka, T, Suda, K, Haze, N, Nakamura, K, Sato, F, Kimura, K, Motoyoshi, M, Mizuki, S, Tagawa, S, Ohga, K, Hatake, A H, Drummond, S, Nagata   +12 more
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