Results 281 to 290 of about 123,724 (326)

Fas and Fas Ligand Expression in Pancreatic Adenocarcinoma

Pancreas, 2002
Fas and Fas ligand (FasL) mediate apoptosis of tumor cells in immune surveillance, and expression of FasL by tumors may mediate their counterattack on cytotoxic lymphocytes. Both proteins are expressed in most if not all pancreatic carcinoma cell lines, but their study in primary human tumors has been limited.We performed Fas and FasL ...
Nat L, Pernick, Fazlul H, Sarkar, Pam, Tabaczka, Glenn, Kotcher, John, Frank, N Volkan, Adsay   +5 more
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Fas and Fas ligand expression in Alzheimer's disease

Acta Neuropathologica, 2001
The Fas/Fas ligand (L) signaling system has been implicated in the control of cell death and cell survival of T and B lymphocytes and in a variety of cell types under particular pathological conditions. In the present study we examined the expression of Fas and Fas-L, by Western blotting and immunohistochemistry, in the human frontal cortex and ...
I, Ferrer, B, Puig, J, Krupinsk, M, Carmona, R, Blanco   +4 more
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Fas and Fas‐ligand expression in seminomatous testes

APMIS, 1999
Sixteen seminomas with surrounding tissue containing normal and precancerous (cis) seminiferous tubules were examined for the expression of Fas (CD95, APO‐1) and Fas ligand (FasL) (CD95L). This was done by analyzing frozen specimens using immunohistochemistry with antibodies directed against Fas and FasL.
O, Braendstrup, B, Bols, L, Jensen
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CD95 (Fas) Ligand

1997
CD95 (Fas/APO-1) is a 45 kD cell surface glycoprotein and member of the tumor necrosis factor receptor superfamily (Nagata and Golstein 1995; Itoh et al. 1991; Oehm et al. 1992; Watanabe-Fukunaga et al. 1992a; Smith et al. 1994). Although CD95 is expressed in many tissues including liver, heart, gut, skin and ovaries (Watanabe-Fukunaga et al.
Richard C. Duke, Paul B. Nash, Mary S. Schleicher, Cynthia Richards, Jodene Moore, Evan Newell, Alex Franzusoff, Donald Bellgrau   +7 more
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Fas ligand in human serum

Nature Medicine, 1996
The Fas ligand (FasL), a member of the tumor necrosis factor family, induces apoptosis in Fas-bearing cells. The membrane-bound human FasL was found to be converted to a soluble form (sFasL) by the action of a matrix metalloproteinase-like enzyme. Two neutralizing monoclonal anti-human FasL antibodies were identified, and an enzyme-linked immunosorbent
M, Tanaka, T, Suda, K, Haze, N, Nakamura, K, Sato, F, Kimura, K, Motoyoshi, M, Mizuki, S, Tagawa, S, Ohga, K, Hatake, A H, Drummond, S, Nagata   +12 more
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Soluble Fas and Fas Ligand in Pregnancy

Angiology, 2011
The pathophysiology of pregnancy-induced hypertension and preeclampsia may involve abnormalities in placentation and the Fas/Fas ligand system. Hypothesizing abnormal plasma Fas and Fas ligand in pregnancy-induced hypertension, we recruited 20 hypertensive pregnant women at mean week 15 and 29 at week 30: 18 were studied at both time points.
Velore J, Karthikeyan, Gregory Y H, Lip, Sabah, Baghdadi, Deirdre A, Lane, D Gareth, Beevers, Andrew D, Blann   +5 more
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Expression of Fas and Fas Ligand in Hodgkin's Disease

Leukemia & Lymphoma, 1999
Fas and Fas ligand expression were investigated in twenty two cases of classical Hodgkin's disease (HD) by immunohistochemistry. While Reed-Sternberg (RS) cells in 7/22 (32%) cases expressed Fas ligand, reactive lymphoid cells expressed Fas ligand in only 2 (9%) cases. In 20/22 (91%) cases, the RS cells expressed Fas. A higher proportion of RS cells in
S S, Metkar, K N, Naresh, A A, Redkar, C S, Soman, S H, Advani, J J, Nadkarni   +5 more
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Fas/Fas Ligand Signaling During Gestational T Cell Development

The Journal of Immunology, 1998
Abstract Most thymocytes express high levels of Fas Ag (Apo-1/CD95); however, the role of Fas/Fas ligand-mediated apoptosis in thymocyte development remains unclear. During gestational development of thymocytes in C57BL/6(B6) +/+ mice, the highest levels of Fas ligand mRNA and Fas ligand protein expression were detected at gestational ...
M, Fleck, T, Zhou, T, Tatsuta, P, Yang, Z, Wang, J D, Mountz   +5 more
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Fas/Fas ligand-mediated apoptosis of murine Langerhans cells

Journal of Dermatological Science, 2000
Epidermal Langerhans cells (LC) are potent antigen-presenting cells (APC), that play a crucial role in initiating cutaneous immune responses. The Fas/Fas ligand pathway has been implicated as an important cellular pathway in the regulation of peripheral immunity.
T, Kawamura, M, Azuma, N, Kayagaki, S, Shimada, H, Yagita, K, Okumura   +5 more
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Upregulation of Fas/Fas ligand in inclusion body myositis

Annals of Neurology, 1998
AbstractIn inclusion body myositis, T cells invade and destroy nonnecrotic muscle fibers. The mechanism by which T cells damage muscle fibers in inflammatory myopathies is not known. In this study we have investigated the expression of Fas and Fas ligand in muscle in five patients with inclusion body myositis.
I M, Fyhr, A, Oldfors
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