Results 81 to 90 of about 52,766 (255)

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Efeito da atividade física com estímulos diferenciados em uma criança com síndrome de Prader-Willi e com contraindicação ao uso de rhGH. Ênfase no IMC e dados de massa corpórea: Um relato de caso

Revista de Saúde, 2017
A Síndrome de Prader-Willi (SPW) é uma desordem genética caracterizada pela ausência da atividade normal do cromossomo 15, em suas bandas 11 e 13 do braço longo.
Marcos Vieira Pinto Da Silva, Lívia Prevot De Souza   +1 more
doaj  

Dual Covalent Targeting of STING Cysteines 292/309 Disrupts Functional Oligomerization and Enables Potent Antagonist Development

Advanced Science, EarlyView.
We report a rational design strategy for STING antagonists by dual covalent targeting of Cys292/309 in its C‐terminal domain, directly preventing functional oligomerization. Through covalent warhead repurposing, we identified P005091 and revealed its unique dual‐cysteine mechanism.
Yuxuan Zhao, Ling Huang, Wenjing Qin, Bin Zhang, Yang Yang, Xue Chen, Xiaoquan Wang, Weilin Zhou, Feiyang Chen, Zhenyu Li, Liyuan Le, Yiqiu Zhang, Zhen Xiang, Lu Zhang, Fei Wang, Dan Lei, Zi‐zhe Cai, Ying Gao, Yong Chen, Xuecen Wang, Junmin Quan, Shuixing Zhang, Xianzhang Bu, Xin Yue   +23 more
wiley   +1 more source

Nanomedicine Meets Immunotherapy: Advancing Adoptive Cell Therapy with Nanoparticles in the Treatment of Cancer with Sustainability Perspectives

Advanced Science, EarlyView.
This review surveys nanoparticle‐based strategies to enhance adoptive cell therapy, particularly CAR‐T cell approaches, in solid tumor treatment. It describes how nanoparticles can improve tumor immunogenicity and T‐cell infiltration while reducing toxicity, and how they enable in vivo CAR‐T cell generation.
Erica Frostegård, Tatiana Bobrova, Amalie Leinebø, Thibault Leray, Shayamita Ghosh, Lorena García‐Hevia, Chiara Puccinelli, Lorenzo Riccio, Jacopo Sorani, Davide Bonifazi, Julien Caumartin, Emmanuel Donnadieu, Florence Gazeau, Roland Hischier, Else Marit Inderberg, Mónica L. Fanarraga, Maria Loustau, Bernd Nowack, Sébastien Wälchli, Cécilia Ménard‐Moyon   +19 more
wiley   +1 more source

Influencia de programas de actividad física en la calidad del sueño de personas mayores de 55 años [PDF]

, 2015
Los trastornos del sueño suponen una importante patología clínica, por lo que adoptar hábitos saludables al dormir resulta clave para la calidad del sueño y de la vida.
Aguilar, José Manuel, Alías-García, Antonio, Cangas Díaz, Adolfo Javier, Fernández-Campoy, Juan Miguel, Gallego Antonio, José, Pérez-Gallardo, Eloy Rafael, Trigueros Ramos, Rubén, Álvarez Hernández, Joaquín   +7 more
core   +2 more sources

The Emerging Parkinson's Disease Oxylipin‐Ome

Advanced Science, EarlyView.
ABSTRACT Parkinson Disease (PD) is increasingly considered a proteinopathy and lipidopathy. This proteinopathy+lipidopathy paradigm has been further refined to a fatty acid (FA)‐opathy, centering dysregulated FA metabolism as fundamental in PD lipid dysfunction.
Julia C. Kelliher, Saranna Fanning
wiley   +1 more source

The BnTFL1‐BnJAM3‐BnSWEETs Module Orchestrates Seed Storage Reserve Accumulation in Brassica napus

Advanced Science, EarlyView.
BnaC03.TFL1 and BnaA01.JAM3 form a complex that facilitates the transport of soluble sugars from the seed coat to the embryo by directly activating the expression of BnSWEETs. Furthermore, BnaC03.TFL1 and BnaA01.JAM3 work cooperatively to promote soluble sugar and oil production while suppressing protein deposition.
Jianjun Wang, Zijin Liu, Minshan Jin, Junting Liu, Shihao Wei, Dengmao Yang, Saiqi Yang, Yuan Guo, Mingxun Chen   +8 more
wiley   +1 more source

Influência da qualidade do sono na saúde, no comportamento e na aprendizagem de adolescentes de 2.º e 3.º Ciclos do Ensino Básico português [PDF]

, 2011
O presente trabalho teve como objectivos averiguar a quantidade e a qualidade de sono dos alunos em função do seu meio de residência, sexo e ano de escolaridade; identificar factores externos que influenciam a redução do tempo de sono; e averiguar a ...
Anastácio, Zélia, Oliveira, Olinda
core  

Ajustamento conjugal, relação mãe-bebê e sintomas psicofuncionais no primeiro ano de vida [PDF]

, 2016
Considerando-se a importância das primeiras relações pais-bebê, este estudo teve como objetivo compreender a interação entre o ajustamento conjugal, a relação mãe-bebê e a manifestação de sintomas psicofuncionais na primeira infância. Participaram quatro
Donelli, Tagma Marina Schneider, Marin, Angela Helena, Peruchi, Rafaela Campos   +2 more
core   +3 more sources

Heterogeneous Wettability‐Based Construction of Two‐Phase Interfaces for Underwater Reversible Adhesion

Advanced Science, EarlyView.
The design employs heterogeneous wettability surfaces that construct stable oil‐water interfaces to achieve robust and rapid reversible adhesion. Linear enhancement of adhesion strength is realized through multi‐interface patterning. This adhesive enables rapid on‐demand detachment within five seconds via voltage‐induced electrolysis, offering a level ...
Xiaokai Li, Yonghui Zhang, Yongxin Li, Jiahao Zhang, Yuheng Li, Zhengyu Li, Jianwu Wang, Yaochen Lv, Yanan Wang, Jiyu Liu, Xin Liu, Huanxi Zheng   +11 more
wiley   +1 more source