Results 181 to 190 of about 449,000 (261)
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
FIT’s graduating BFA class in Fashion Design presents a professional runway show every spring. Each year, industry critics lend their expertise to our graduating students during their final semester as they prepare for the fashion show.
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Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
2010 FIT Fashion Show part 5: Knitwear, Sportswear, Menswear
Knitwear, Sportswear, and Menswear designed by graduating students in FIT's BFA fashion design program.
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Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology
Molecular Oncology, EarlyView.This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic +15 more
wiley +1 more source
Fashion in the Nineties Symposium: "1990s Fashion Ephemera: Trends, Desire, and Exclusivity"
Graphic designer Paul Boudens and assistant professor and director of the MA in Fashion Studies at The New School Parsons Paris Dr. Marco Pecorari discuss 90s Fashion Ephemera: Trends, Desire, and Exclusivity for The Museum at FIT's 26th academic ...
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Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
MFIT Curator Colleen Hill discusses the reasons behind curating an exhibition about the decade that closed out the last century for The Museum at FIT's 26th academic symposium “Reinvention and Restlessness: Fashion in the Nineties” on February 11, 2022 ...
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