Results 211 to 220 of about 449,000 (261)

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Fashion education and fashion trend

Research abstracts on the annual meeting, regular meeting and seminar of the Japan Association of Home Economics Education, 2012
openaire   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Fashion Dreams or Fashion Business:Helsinki as an Emerging Fashion Scene

, 2019
Chun, Namkyu, Niinimäki, Kirsi, Gurova, Olga   +2 more
openaire   +1 more source

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Fashion and Homophily

Operations Research, 2013
We analyze the evolution of fashion based on a network game model. Each agent in this model is a conformist or a rebel. A conformist prefers to take the action most common among her neighboring agents, whereas a rebel prefers the opposite. When there is only one type of agents, the model possesses an exact potential function, implying that fashion ...
Boyu Zhang, Zhigang Cao 0002, Cheng-Zhong Qin, Xiaoguang Yang 0001   +3 more
openaire   +3 more sources

Fashionable and Objectionably Fashionable

JAMA: The Journal of the American Medical Association, 1976
The word "fashions" first brings to mind the things people wear or don't wear. Some such fashions are whims of the wearers. For example, ornate necklaces, affected by America's first inhabitants, were adopted by mountain men of the 18th century, later became bolos in the western United States, and then moved east in less attractive form.
openaire   +2 more sources

Fashion as Art; is Fashion Art?

Fashion Theory, 2007
AbstractThe question whether fashion can be regarded as a form of art begs the question of what kinds of things can legitimately be thus regarded. In the first section, some of the most recent contributions to dealing with this issue are critically analyzed.
openaire   +2 more sources

Radical Fashion and Radical Fashion Innovation

Journal of Global Fashion Marketing, 2010
This is a study of the related concepts of radical fashion and radical fashion innovation. Radical fashions are defined here as those that may never enter the market at all, and exist primarily on runway shows, in exhibitions and in publicity; by contrast, radical fashion innovations may be very successful in the marketplace. Radical fashions represent
Zhang, D., Benedetto, Di, A.C.
openaire   +2 more sources

Fashion after Fashion

Fashion Theory, 2018
In 2015 fashion’s pre-eminent industry consultant and trend forecaster, Li Edelkoort, released an ebullient manifesto declaring that fashion was dead.
openaire   +1 more source