Results 121 to 130 of about 9,648,146 (309)
Molecular Oncology, EarlyView.In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico +5 more
wiley +1 more source
Molecular Oncology, EarlyView.This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault +12 more
wiley +1 more source
Ralph Rucci at the Queer History of Fashion Symposium
Fashion designer Ralph Rucci presents “The Greatest Gay Fashion Designers” at The Museum at FIT’s 13th fashion symposium, A Queer History of Fashion, held November 8-9, 2013. This is an edited version of the full talk, which is available for check out at
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Molecular Oncology, EarlyView.Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso +5 more
wiley +1 more source
Acervo, 2018 Regina A. Root (raroot@wm.edu) is Professor of Hispanic Studies at William & Mary, the historic university in Williamsburg, Virginia. She is an international expert known for her work on fashion, textiles, and Latin American cultural production.
Maria do Carmo Rainho +1 more
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2007 FIT Fashion Show: Children's Wear
FIT's fashion design seniors are the "Rising New Stars 2007." Student designs in children's wear are presented at the annual student fashion ...
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Molecular Oncology, EarlyView.The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim +17 more
wiley +1 more source
2007 FIT Fashion Show: Current Scene
FIT's fashion design seniors are the "Rising New Stars 2007." Student designs in "current scene" are presented at the annual student fashion ...
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Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source